Inhibitory effect of norharmane on Serratia marcescens NJ01 quorum sensing-mediated virulence factors and biofilm formation

• Published in: Biofouling (Chur, Switzerland) Vol. 37; no. 2; pp. 145 - 160
• Main Authors: Luo, Huai-Zhi, Zhou, Jin-Wei, Sun, Bing, Jiang, Huan, Tang, Shi, Jia, Ai-Qun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.02.2021; Taylor & Francis Ltd
• Subjects: Analytical methods; Anti-Bacterial Agents - pharmacology; anti-biofilm; Antibiotics; Bacteria; Bacterial diseases; Biofilms; carboline derivatives; Carbolines - pharmacology; Chlorosis; DNA; Exopolysaccharides; Exposure; Fatty acids; Fourier transforms; Genes; Infrared analysis; Infrared spectroscopy; Norharmane; Nucleic acids; Nucleotide sequence; Ofloxacin; Pathogens; PCR; Polymerase chain reaction; Protein structure; Quorum Sensing; quorum sensing inhibitors; Serratia marcescens; Serratia marcescens - genetics; Spectroscopy, Fourier Transform Infrared; Tertiary; Tertiary structure; Tomatoes; Virulence; Virulence factors; Virulence Factors - genetics; Wilting; carboline derivatives; Norharmane; quorum sensing; quorum sensing inhibitors; anti-biofilm; Serratia marcescens

Serratia marcescens NJ01, a Gram-negative bacterium, can infect tomato leaves and cause chlorosis and wilting. The present study evaluated the quorum sensing (QS) and biofilm inhibitory effects of seven carboline compounds against S. marcescens NJ01 at 20 μg ml −1 , and subsequently focused the stud...