Multicellular spheroids in ovarian cancer metastases: Biology and pathology

• Published in: Gynecologic oncology Vol. 113; no. 1; pp. 143 - 148
• Main Authors: Shield, Kristy, Ackland, M. Leigh, Ahmed, Nuzhat, Rice, Gregory E
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2009
• Subjects: Chemo-resistance; Chemotherapy; Epithelial ovarian cancer; Female; Hematology, Oncology and Palliative Medicine; Humans; Metastasis; Neoplasm Metastasis; Obstetrics and Gynecology; Ovarian Neoplasms - pathology; Spheroids; Spheroids, Cellular - pathology; Chemo-resistance; Chemotherapy; Metastasis; Epithelial ovarian cancer; Spheroids

Abstract Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC...