Multicellular spheroids in ovarian cancer metastases: Biology and pathology

Abstract Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC...

Full description

Saved in:
Bibliographic Details
Published inGynecologic oncology Vol. 113; no. 1; pp. 143 - 148
Main Authors Shield, Kristy, Ackland, M. Leigh, Ahmed, Nuzhat, Rice, Gregory E
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2009
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Abstract Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to treat is that the mechanism of dissemination is unusual. EOC dissemination characteristically involves local invasion of pelvic and abdominal organs. Unlike many epithelial cancers, initial dissemination rarely requires the vasculature, although the vasculature is often implicated in the advanced stages of disease. Recently, it has become apparent that aggregates of malignant cells (spheroids) contained within malignant ascites represent a significant impediment to efficacious treatment of late stage EOC. In vivo , spheroids are present in the malignant ascites of EOC patients, while in vitro cultured spheroids are capable of tumorgenesis in vivo and display a reduced response to chemotherapeutic drugs when compared to monolayers. A major problem associated with the current generation of chemotherapy agents is that they do not address the anchorage- and vascular-independent growth conditions associated with a 3-dimensional structure that has formed and/or grown in suspension. Thus, spheroid formation may represent a key component of platinum/taxane-sensitive recurrence. If this is correct, a better understanding of spheroid biology may contribute to the identification of new treatment opportunities for the sustained treatment of metastatic EOC. This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality.
AbstractList Epithelial ovarian cancer (EOC) has a relatively high mortality rate ( approximately 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to treat is that the mechanism of dissemination is unusual. EOC dissemination characteristically involves local invasion of pelvic and abdominal organs. Unlike many epithelial cancers, initial dissemination rarely requires the vasculature, although the vasculature is often implicated in the advanced stages of disease. Recently, it has become apparent that aggregates of malignant cells (spheroids) contained within malignant ascites represent a significant impediment to efficacious treatment of late stage EOC. In vivo, spheroids are present in the malignant ascites of EOC patients, while in vitro cultured spheroids are capable of tumorgenesis in vivo and display a reduced response to chemotherapeutic drugs when compared to monolayers. A major problem associated with the current generation of chemotherapy agents is that they do not address the anchorage- and vascular-independent growth conditions associated with a 3-dimensional structure that has formed and/or grown in suspension. Thus, spheroid formation may represent a key component of platinum/taxane-sensitive recurrence. If this is correct, a better understanding of spheroid biology may contribute to the identification of new treatment opportunities for the sustained treatment of metastatic EOC. This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality.
Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to treat is that the mechanism of dissemination is unusual. EOC dissemination characteristically involves local invasion of pelvic and abdominal organs. Unlike many epithelial cancers, initial dissemination rarely requires the vasculature, although the vasculature is often implicated in the advanced stages of disease. Recently, it has become apparent that aggregates of malignant cells (spheroids) contained within malignant ascites represent a significant impediment to efficacious treatment of late stage EOC. In vivo, spheroids are present in the malignant ascites of EOC patients, while in vitro cultured spheroids are capable of tumorgenesis in vivo and display a reduced response to chemotherapeutic drugs when compared to monolayers. A major problem associated with the current generation of chemotherapy agents is that they do not address the anchorage- and vascular-independent growth conditions associated with a 3-dimensional structure that has formed and/or grown in suspension. Thus, spheroid formation may represent a key component of platinum/taxane-sensitive recurrence. If this is correct, a better understanding of spheroid biology may contribute to the identification of new treatment opportunities for the sustained treatment of metastatic EOC. This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality.
Abstract Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes are unable to achieve sustained remission, despite frequently producing a positive response at first treatment. One of the reasons that EOC is difficult to treat is that the mechanism of dissemination is unusual. EOC dissemination characteristically involves local invasion of pelvic and abdominal organs. Unlike many epithelial cancers, initial dissemination rarely requires the vasculature, although the vasculature is often implicated in the advanced stages of disease. Recently, it has become apparent that aggregates of malignant cells (spheroids) contained within malignant ascites represent a significant impediment to efficacious treatment of late stage EOC. In vivo , spheroids are present in the malignant ascites of EOC patients, while in vitro cultured spheroids are capable of tumorgenesis in vivo and display a reduced response to chemotherapeutic drugs when compared to monolayers. A major problem associated with the current generation of chemotherapy agents is that they do not address the anchorage- and vascular-independent growth conditions associated with a 3-dimensional structure that has formed and/or grown in suspension. Thus, spheroid formation may represent a key component of platinum/taxane-sensitive recurrence. If this is correct, a better understanding of spheroid biology may contribute to the identification of new treatment opportunities for the sustained treatment of metastatic EOC. This review article outlines the key biological features of spheroids, specifically discussing their role in EOC dissemination and chemo-response as well as providing insights into spheroid functionality.
Author Rice, Gregory E
Ahmed, Nuzhat
Ackland, M. Leigh
Shield, Kristy
Author_xml – sequence: 1
  fullname: Shield, Kristy
– sequence: 2
  fullname: Ackland, M. Leigh
– sequence: 3
  fullname: Ahmed, Nuzhat
– sequence: 4
  fullname: Rice, Gregory E
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19135710$$D View this record in MEDLINE/PubMed
BookMark eNqFkU1r3DAQhkVJaDZpf0Gh-NSb3ZHkD7nQQhv6EZLQQ9uzGMvjRFuvtJHsgP995exCoZfCwMzA-84wz5yzE-cdMfaKQ8GB12-3xXK3OF8IAFVwXoAUz9iGQ1vltaraE7YBaCFXolJn7DzGLQBI4OI5O-Mtl1XDYcOub-dxsobGcR4xZHF_T8HbPmbWZf4Rg0WXGXSGQrajCWMKiu-yT9aP_m7J0PXZHqf7p-4FOx1wjPTymC_Yry-ff15-y2--f726_HiTm7JRUy65QpJdXympqg4ESo6V5I1oeiyRsJQGh27oTUdYU0MAg6iFEKYc5NC3Ul6wN4e5--AfZoqT3tm4noCO_Bx13UBVNbJMQnkQmuBjDDTofbA7DIvmoFeGequfGOqVoeZcJ4bJ9fo4fu521P_1HKElwfuDgNKRj5aCjsZSYtTbQGbSvbf_WfDhH78ZrbMGx9-0UNz6ObjET3MdhQb9Y33j-kVQqWpKJf8AYeWb2g
CitedBy_id crossref_primary_10_3390_jcm8101658
crossref_primary_10_1007_s00432_019_02973_5
crossref_primary_10_1039_D2AY00161F
crossref_primary_10_1021_acs_biomac_6b01469
crossref_primary_10_1088_1748_605X_abc3dd
crossref_primary_10_18632_oncotarget_27626
crossref_primary_10_1016_j_bbrc_2016_02_049
crossref_primary_10_1002_ctm2_1176
crossref_primary_10_1158_1535_7163_MCT_20_0119
crossref_primary_10_1109_ACCESS_2022_3146887
crossref_primary_10_3390_cancers14051274
crossref_primary_10_1186_s13287_021_02256_2
crossref_primary_10_1021_acs_molpharmaceut_7b00843
crossref_primary_10_1089_ten_tec_2015_0280
crossref_primary_10_1158_1078_0432_CCR_12_1513
crossref_primary_10_1016_j_phrs_2020_105076
crossref_primary_10_1177_1179064418767882
crossref_primary_10_1172_JCI69815
crossref_primary_10_1371_journal_pone_0136361
crossref_primary_10_1002_biot_202200434
crossref_primary_10_1016_j_ijnonlinmec_2022_104063
crossref_primary_10_3390_cancers12082269
crossref_primary_10_1021_acs_molpharmaceut_5b00426
crossref_primary_10_1038_s41416_023_02355_2
crossref_primary_10_5458_bag_12_3_140
crossref_primary_10_1016_j_mbplus_2023_100136
crossref_primary_10_3390_ijms21134637
crossref_primary_10_1016_j_ejca_2013_03_016
crossref_primary_10_1016_j_yexcr_2020_112397
crossref_primary_10_1038_s41598_018_25589_0
crossref_primary_10_1007_s13277_010_0017_9
crossref_primary_10_3389_fphar_2024_1363142
crossref_primary_10_1073_pnas_1505979112
crossref_primary_10_1155_2018_5284814
crossref_primary_10_3389_fonc_2021_690618
crossref_primary_10_21294_1814_4861_2019_18_1_116_123
crossref_primary_10_3390_cancers14040958
crossref_primary_10_1002_advs_201903718
crossref_primary_10_1111_j_1365_2303_2011_00847_x
crossref_primary_10_1186_1471_2407_14_620
crossref_primary_10_1530_ERC_15_0383
crossref_primary_10_18632_oncotarget_27767
crossref_primary_10_1038_s41598_019_42836_0
crossref_primary_10_1371_journal_pone_0084941
crossref_primary_10_3390_cancers12040850
crossref_primary_10_3390_jcm9040924
crossref_primary_10_1016_j_tranon_2021_101318
crossref_primary_10_1016_j_jbiotec_2010_01_012
crossref_primary_10_3892_ijo_2017_3891
crossref_primary_10_1016_j_jconrel_2012_09_003
crossref_primary_10_1002_advs_202304989
crossref_primary_10_1186_s40425_019_0666_1
crossref_primary_10_1371_journal_pone_0058226
crossref_primary_10_1016_j_bbcan_2023_189003
crossref_primary_10_1016_j_ygyno_2017_04_014
crossref_primary_10_1038_srep05646
crossref_primary_10_1530_ERC_18_0132
crossref_primary_10_1210_js_2018_00272
crossref_primary_10_1016_j_bcp_2020_114149
crossref_primary_10_1016_j_tice_2017_11_003
crossref_primary_10_1002_cam4_2334
crossref_primary_10_1371_journal_pone_0151089
crossref_primary_10_1111_cas_12987
crossref_primary_10_3389_fonc_2022_837233
crossref_primary_10_1111_cas_15100
crossref_primary_10_1158_1535_7163_MCT_13_1063
crossref_primary_10_1097_CAD_0000000000000872
crossref_primary_10_3389_fmats_2023_1223276
crossref_primary_10_1002_term_2609
crossref_primary_10_3390_cells7120277
crossref_primary_10_1371_journal_pone_0018872
crossref_primary_10_1186_1757_2215_3_8
crossref_primary_10_1242_jcs_123836
crossref_primary_10_1016_j_actbio_2021_04_032
crossref_primary_10_1016_j_canlet_2021_01_024
crossref_primary_10_1515_caim_2017_0001
crossref_primary_10_1158_1541_7786_MCR_16_0323_T
crossref_primary_10_1016_j_bbcan_2013_12_003
crossref_primary_10_3390_ijms23084383
crossref_primary_10_1002_jcb_28147
crossref_primary_10_20538_1682_0363_2023_2_122_133
crossref_primary_10_1038_onc_2012_290
crossref_primary_10_1309_AJCPGXK0FR4MHIHB
crossref_primary_10_1016_j_canlet_2015_07_032
crossref_primary_10_1002_cpz1_529
crossref_primary_10_1038_s41378_020_0130_x
crossref_primary_10_3390_s20113327
crossref_primary_10_1007_s11596_015_1443_0
crossref_primary_10_1002_bit_24399
crossref_primary_10_3390_cancers13164216
crossref_primary_10_1038_s41419_020_03009_4
crossref_primary_10_3390_ijms23020833
crossref_primary_10_1007_s11033_023_09168_9
crossref_primary_10_1007_s10585_014_9658_1
crossref_primary_10_1158_1078_0432_CCR_14_1578
crossref_primary_10_3390_ijms12128489
crossref_primary_10_1186_s13008_022_00079_y
crossref_primary_10_1002_mabi_201800351
crossref_primary_10_1007_s10585_016_9821_y
crossref_primary_10_1016_j_yexcr_2013_11_011
crossref_primary_10_1038_bjc_2013_673
crossref_primary_10_1016_j_colsurfa_2014_03_085
crossref_primary_10_1038_s41467_020_20140_0
crossref_primary_10_1038_s41598_020_67565_7
crossref_primary_10_1016_j_isci_2024_109245
crossref_primary_10_1111_jcmm_14848
crossref_primary_10_1021_acs_jmedchem_8b00930
crossref_primary_10_1063_5_0132254
crossref_primary_10_3390_cancers14102362
crossref_primary_10_1088_1748_605X_ad3311
crossref_primary_10_3390_molecules26164949
crossref_primary_10_1038_mto_2015_13
crossref_primary_10_1051_mmnp_20105109
crossref_primary_10_1016_j_ygyno_2013_12_031
crossref_primary_10_3389_fonc_2020_00144
crossref_primary_10_3390_biom11111711
crossref_primary_10_1371_journal_pone_0057056
crossref_primary_10_1186_s13048_015_0182_y
crossref_primary_10_1002_1878_0261_13028
crossref_primary_10_1016_j_isci_2023_108081
crossref_primary_10_1134_S1990519X13030127
crossref_primary_10_1186_s13048_020_00660_5
crossref_primary_10_1002_mc_22474
crossref_primary_10_1016_j_ygyno_2010_11_029
crossref_primary_10_1080_17425247_2024_2307481
crossref_primary_10_1007_s40843_019_1272_0
crossref_primary_10_1039_C8AN00729B
crossref_primary_10_1186_s12917_023_03834_7
crossref_primary_10_1002_anbr_202100017
crossref_primary_10_3389_fonc_2021_746411
crossref_primary_10_1007_s00018_022_04395_y
crossref_primary_10_1186_s13046_019_1465_8
crossref_primary_10_3390_ijms241210079
crossref_primary_10_1111_j_1349_7006_2010_01652_x
crossref_primary_10_4049_jimmunol_2001095
crossref_primary_10_1371_journal_pone_0168389
crossref_primary_10_1002_adhm_202001368
crossref_primary_10_1021_acsbiomaterials_6b00662
crossref_primary_10_1186_s40643_020_00325_7
crossref_primary_10_1021_acsabm_1c01138
crossref_primary_10_1007_s10585_013_9615_4
crossref_primary_10_1172_jci_insight_86829
crossref_primary_10_1371_journal_pone_0136893
crossref_primary_10_1177_2472555219880194
crossref_primary_10_1007_s12013_024_01246_4
crossref_primary_10_3390_ijms19020450
crossref_primary_10_1016_j_eng_2020_10_001
crossref_primary_10_18632_oncotarget_3658
crossref_primary_10_3389_fmolb_2023_1223493
crossref_primary_10_1158_0008_5472_CAN_16_1115
crossref_primary_10_5306_wjco_v9_i8_167
crossref_primary_10_1186_s12943_015_0417_y
crossref_primary_10_1007_s10555_011_9337_5
crossref_primary_10_1186_1471_2407_14_317
crossref_primary_10_3892_ijo_2013_1960
crossref_primary_10_1093_jnci_djq256
crossref_primary_10_1002_biot_202000250
crossref_primary_10_1007_s00384_021_04070_x
crossref_primary_10_1080_1061186X_2016_1238091
crossref_primary_10_3390_cancers13225745
crossref_primary_10_1002_1878_0261_12845
crossref_primary_10_1016_j_colsurfa_2013_01_030
crossref_primary_10_1038_oncsis_2016_64
crossref_primary_10_3390_cancers15041282
crossref_primary_10_3390_microarrays2030208
crossref_primary_10_18632_oncotarget_22475
crossref_primary_10_3390_ijms12021334
crossref_primary_10_3390_cells10092272
crossref_primary_10_1371_journal_pone_0111806
crossref_primary_10_1158_0008_5472_CAN_21_0622
crossref_primary_10_1158_1078_0432_CCR_14_0713
crossref_primary_10_1016_j_pharmthera_2017_10_018
crossref_primary_10_3389_fcell_2021_764375
crossref_primary_10_1016_j_addr_2014_06_005
crossref_primary_10_1016_j_ygyno_2018_01_023
crossref_primary_10_1186_s13046_019_1127_x
crossref_primary_10_3389_fmolb_2022_921298
crossref_primary_10_1186_s13046_023_02820_z
crossref_primary_10_18632_oncotarget_23679
crossref_primary_10_3390_jpm14010049
crossref_primary_10_1016_j_biomaterials_2024_122663
crossref_primary_10_1016_j_yexcr_2013_05_003
crossref_primary_10_3390_cells11050824
crossref_primary_10_1016_j_actbio_2014_02_035
crossref_primary_10_1038_s41385_022_00565_0
crossref_primary_10_1111_cas_14098
crossref_primary_10_2147_CMAR_S320834
crossref_primary_10_3390_ijms21051833
crossref_primary_10_1080_15376516_2021_2009949
crossref_primary_10_3389_fbioe_2023_1160985
crossref_primary_10_4081_oncol_2020_475
crossref_primary_10_3390_cancers12010024
crossref_primary_10_1016_j_ejps_2020_105542
crossref_primary_10_1021_acschembio_6b01094
crossref_primary_10_1002_ijc_33408
crossref_primary_10_1007_s13577_020_00455_2
crossref_primary_10_1016_j_bbcan_2016_10_002
crossref_primary_10_3390_cells11132093
crossref_primary_10_1016_j_ygyno_2012_09_001
crossref_primary_10_3390_ijms22168362
crossref_primary_10_1016_j_yexcr_2018_05_010
crossref_primary_10_1038_s41416_020_0875_x
crossref_primary_10_1016_j_mbs_2024_109168
crossref_primary_10_1186_1471_2407_12_359
crossref_primary_10_3389_fphys_2017_00605
crossref_primary_10_1021_acsabm_4c00076
crossref_primary_10_1097_IGC_0b013e318263ef34
crossref_primary_10_1210_clinem_dgab195
crossref_primary_10_3390_ijms19010181
crossref_primary_10_1016_j_canlet_2019_05_029
crossref_primary_10_1002_ijc_32673
crossref_primary_10_1038_s41388_020_1288_2
crossref_primary_10_1016_j_ygyno_2012_01_048
crossref_primary_10_1074_jbc_M115_639773
crossref_primary_10_3390_cancers14061399
crossref_primary_10_1093_carcin_bgr241
crossref_primary_10_3390_biomedicines10020271
crossref_primary_10_1007_s10585_011_9451_3
crossref_primary_10_1016_j_pharmthera_2016_05_007
crossref_primary_10_1242_bio_2012653
crossref_primary_10_1016_j_ijbiomac_2022_12_266
crossref_primary_10_3390_biom13060900
crossref_primary_10_3892_ijmm_2019_4361
crossref_primary_10_1038_s41598_021_85356_6
crossref_primary_10_1016_j_tiv_2019_104599
crossref_primary_10_1007_s10856_013_4908_3
crossref_primary_10_1016_j_nantod_2022_101459
crossref_primary_10_1016_j_canlet_2021_08_018
crossref_primary_10_1016_j_bbcan_2023_189052
crossref_primary_10_1016_j_jtbi_2021_110980
crossref_primary_10_1038_s41388_018_0317_x
crossref_primary_10_3389_fbioe_2022_836984
crossref_primary_10_3390_pharmaceutics13111891
crossref_primary_10_18632_oncotarget_4211
crossref_primary_10_1093_carcin_bgu049
crossref_primary_10_1371_journal_pone_0182930
crossref_primary_10_1089_adt_2014_573
crossref_primary_10_3390_cancers10090295
crossref_primary_10_1002_pmic_202000304
crossref_primary_10_20538_1682_0363_2018_3_188_196
crossref_primary_10_1016_j_biopha_2020_110872
crossref_primary_10_1063_1_5091713
crossref_primary_10_1002_prca_201700124
crossref_primary_10_1089_ten_tec_2019_0053
crossref_primary_10_1038_s41388_019_0881_8
crossref_primary_10_1038_s41598_017_01355_6
crossref_primary_10_1186_s12967_022_03404_9
crossref_primary_10_1158_0008_5472_CAN_09_3415
crossref_primary_10_1039_c3ib20252f
crossref_primary_10_1158_0008_5472_CAN_15_1620
crossref_primary_10_1245_s10434_013_2878_9
crossref_primary_10_1016_j_yexcr_2010_06_026
crossref_primary_10_1007_s12015_017_9720_x
crossref_primary_10_3390_ijms22010305
crossref_primary_10_1007_s10585_012_9562_5
crossref_primary_10_1016_j_biomaterials_2010_07_064
crossref_primary_10_3390_cancers9080104
crossref_primary_10_1016_j_tiv_2016_10_009
crossref_primary_10_1002_advs_201800927
crossref_primary_10_1038_srep30061
crossref_primary_10_1038_s41598_017_05562_z
crossref_primary_10_1186_s12943_016_0542_2
crossref_primary_10_1016_j_jconrel_2012_04_045
crossref_primary_10_3390_cancers12051250
crossref_primary_10_1016_j_jtbi_2018_02_022
crossref_primary_10_3390_cancers12030699
crossref_primary_10_1016_j_neo_2014_12_004
crossref_primary_10_1039_c1sc00337b
crossref_primary_10_59277_RomRepPhys_2024_76_601
crossref_primary_10_1002_cyto_a_22306
crossref_primary_10_1016_j_biomaterials_2013_06_009
crossref_primary_10_2139_ssrn_3947352
crossref_primary_10_1016_j_jcyt_2012_10_003
crossref_primary_10_1016_j_biomaterials_2022_121728
crossref_primary_10_1007_s00285_016_1042_0
crossref_primary_10_1002_1878_0261_13556
crossref_primary_10_4161_epi_5_8_13014
crossref_primary_10_1590_1414_431X20132647
Cites_doi 10.1080/095530099139845
10.1080/00016340701463889
10.1016/j.ygyno.2008.05.031
10.1111/j.1471-0528.1989.tb03341.x
10.1002/jcp.21240
10.1158/1535-7163.MCT-07-0118
10.1080/09553007014551401
10.1002/(SICI)1097-4644(19960616)61:4<531::AID-JCB6>3.0.CO;2-P
10.1073/pnas.90.8.3294
10.1016/S0303-7207(03)00068-6
10.1161/01.RES.0000156274.72390.2c
10.1017/S1462399407000324
10.1016/j.humpath.2006.03.003
10.1152/ajpcell.1997.273.4.C1109
10.1002/ijc.11086
10.1158/0008-5472.CAN-05-0626
10.1186/1477-3163-6-11
10.1007/s10585-004-5768-5
10.1002/mc.20315
10.1016/j.critrevonc.2006.03.004
10.3322/canjclin.57.1.43
10.1038/nm1230
10.1200/JCO.2007.11.1088
10.1097/01.pgp.0000101080.35393.16
10.1593/neo.07472
10.1016/j.ceb.2005.08.014
10.1186/1479-5876-4-6
10.1016/j.ygyno.2003.12.034
10.1016/S1028-4559(08)60007-8
10.1002/(SICI)1097-4644(20000701)78:1<141::AID-JCB13>3.0.CO;2-R
10.1016/j.ygyno.2007.03.036
10.1158/0008-5472.CAN-04-3931
10.1023/A:1012259625746
10.1074/jbc.273.27.16953
10.1016/j.clon.2005.05.009
10.1056/NEJMra041842
10.1002/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-R
10.1016/j.ygyno.2006.07.004
10.1002/ijc.2910580315
10.1038/nrc1611
10.1146/annurev.bi.54.070185.003313
10.1158/0008-5472.CAN-08-0364
10.1006/gyno.1998.5275
10.1200/JCO.2006.10.2517
10.1186/1471-2164-9-99
10.1016/S0092-8674(00)81279-9
10.1016/j.ctrv.2006.07.006
10.1080/15419060600877978
10.1242/jcs.02508
ContentType Journal Article
Copyright Elsevier Inc.
2008 Elsevier Inc.
Copyright_xml – notice: Elsevier Inc.
– notice: 2008 Elsevier Inc.
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1016/j.ygyno.2008.11.032
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
MEDLINE


Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1095-6859
EndPage 148
ExternalDocumentID 10_1016_j_ygyno_2008_11_032
19135710
S0090825808009748
1_s2_0_S0090825808009748
Genre Journal Article
Review
GroupedDBID ---
--K
--M
.1-
.55
.FO
.GJ
.~1
0R~
1B1
1P~
1RT
1~.
1~5
29I
3O-
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
71M
8P~
9JM
AABNK
AACTN
AAEDT
AAEDW
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQQT
AAQXK
AAXKI
AAXUO
ABBQC
ABFNM
ABFRF
ABJNI
ABMAC
ABMZM
ABXDB
ACDAQ
ACGFO
ACGFS
ACRLP
ADBBV
ADEZE
ADFGL
ADMUD
AEBSH
AEFWE
AEKER
AENEX
AEVXI
AFCTW
AFFNX
AFJKZ
AFKWA
AFRHN
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJOXV
AJRQY
AJUYK
AKRWK
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CAG
COF
CS3
DM4
DU5
EBS
EFBJH
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HED
HMK
HMO
HVGLF
HZ~
IH2
IHE
J1W
K-O
KOM
L7B
LG5
M29
M41
MO0
N9A
O-L
O9-
OAUVE
OQ.
OZT
P-8
P-9
P2P
PC.
PH~
Q38
R2-
RIG
ROL
RPZ
SAE
SCC
SDF
SDG
SDP
SES
SEW
SPCBC
SSH
SSZ
T5K
UDS
UHS
UV1
WUQ
X7M
XPP
Z5R
ZGI
ZMT
ZU3
ZXP
~G-
AAIAV
ABLVK
ABYKQ
AHPSJ
AJBFU
EFLBG
LCYCR
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
ACRPL
ADNMO
CITATION
7X8
ID FETCH-LOGICAL-c478t-318ae3bd58385b02a31a531727da4aea43cafbfdcbea6e7e00f26222c4f3fd933
IEDL.DBID .~1
ISSN 0090-8258
IngestDate Wed Dec 04 15:57:53 EST 2024
Fri Dec 06 01:28:42 EST 2024
Sat Sep 28 07:56:53 EDT 2024
Fri Feb 23 02:18:48 EST 2024
Tue Oct 15 22:55:36 EDT 2024
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Chemo-resistance
Chemotherapy
Metastasis
Epithelial ovarian cancer
Spheroids
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c478t-318ae3bd58385b02a31a531727da4aea43cafbfdcbea6e7e00f26222c4f3fd933
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMID 19135710
PQID 67055734
PQPubID 23479
PageCount 6
ParticipantIDs proquest_miscellaneous_67055734
crossref_primary_10_1016_j_ygyno_2008_11_032
pubmed_primary_19135710
elsevier_sciencedirect_doi_10_1016_j_ygyno_2008_11_032
elsevier_clinicalkeyesjournals_1_s2_0_S0090825808009748
PublicationCentury 2000
PublicationDate 2009-04-01
PublicationDateYYYYMMDD 2009-04-01
PublicationDate_xml – month: 04
  year: 2009
  text: 2009-04-01
  day: 01
PublicationDecade 2000
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Gynecologic oncology
PublicationTitleAlternate Gynecol Oncol
PublicationYear 2009
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Hagemann, Robinson, Thompson, Charles, Kulbe, Balkwill (bib21) 2007; 6
Kim, Sauer, Testa, Wahl, Svoboda, Johnson (bib36) 2005; 118
Dubeau (bib10) 1999; 72
Zietarska, Maugard, Filali-Mouhim, Alam-Fahmy, Tonin, Provencher (bib8) 2007; 46
Wang (bib55) 1985; 54
Aberle, Schwartz, Kemler (bib27) 1996; 61
Mueller-Klieser (bib41) 1997; 273
Puiffe, Le Page, Filali-Mouhim, Zietarska, Ouellet, Tonin (bib24) 2007; 9
de Bree, Theodoropoulos, Rosing, Michalakis, Romanos, Beijnen (bib59) 2006; 32
Sutherland, Inch, McCredie, Kruuv (bib45) 1970; 18
Bapat, Mali, Koppikar, Kurrey (bib48) 2005; 65
Zhang, Balch, Chan, Lai, Matei, Schilder (bib47) 2008; 68
Islam, Kim, Trendel, Wheelock, Johnson (bib38) 2000; 78
Guppy, Nathan, Rustin (bib53) 2005; 17
Shepherd (bib18) 1989; 96
Burleson, Casey, Skubitz, Pambuccian, Oegema, Skubitz (bib23) 2004; 93
Zhu, Sundfeldt (bib32) 2007; 86
Sundfeldt (bib33) 2003; 202
Lin, Changchien (bib52) 2007; 46
Jemal, Siegel, Ward, Murray, Xu, Thun (bib1) 2007; 57
Allen, Porter, Gamarra, Piver, Johnson (bib4) 1987; 55
Waleh, Gallo, Grant, Murphy, Kramer, Sutherland (bib25) 1994; 54
Hamilton CA, Maxwell GL, Chernofsky MR, Bernstein SA, Farley JH, Rose GS. Intraperitoneal bevacizumab for the palliation of malignant ascites in refractory ovarian cancer. Gynecol Oncol (in press).
(bib2) 2006
Veatch, Carson, Ramakrishnan (bib35) 1994; 58
Cannistra (bib17) 2004; 351
Morris, Tawil, Berkova, Wible, Smith, Cunningham (bib29) 2006; 13
Kobayashi, Man, Graham, Kapitain, Teicher, Kerbel (bib44) 1993; 90
Naora (bib13) 2007; 9
L'Esperance, Bachvarova, Tetu, Mes-Masson, Bachvarov (bib6) 2008; 9
Winter, Maxwell, Tian, Carlson, Ozols, Rose (bib50) 2007; 25
Ponti, Costa, Zaffaroni, Pratesi, Petrangolini, Coradini (bib49) 2005; 65
Sutherland, Durand (bib43) 1976; 11
Makhija, Taylor, Gibb, Gercel-Taylor (bib46) 1999; 14
Ahmed, Thompson, Quinn (bib19) 2007; 213
Kantak, Kramer (bib22) 1998; 273
Piccart, Lamb, Vermorken (bib54) 2001; 12
Auersperg, Woo, Gilks (bib9) 2008; 110
Nishio, Sugiyama, Shouji, Yoshizaki, Kitagawa, Ushijima (bib56) 2007; 106
Burleson, Boente, Pambuccian, Skubitz (bib5) 2006; 4
Seidman, Horkayne-Szakaly, Haiba, Boice, Kurman, Ronnett (bib11) 2004; 23
Sarrio, Moreno-Bueno, Sanchez-Estevez, Banon-Rodriguez, Hernandez-Cortes, Hardisson (bib34) 2006; 37
Sutherland, McCredie, Inch (bib42) 1971; 46
Kostetskii, Li, Xiong, Zhou, Ferrari, Patel (bib28) 2005; 96
Ivascu, Kubbies (bib37) 2007; 31
Auersperg, Wong, Choi, Kang, Leung (bib12) 2001; 22
Shield, Riley, Quinn, Rice, Ackland, Ahmed (bib7) 2007; 6
Cheng, Liu, Yoshida, Rosen, Naora (bib15) 2005; 11
Patel, Madan, Getsios, Bertrand, MacCalman (bib31) 2003; 106
Colombo, Van Gorp, Parma, Amant, Gatta, Sessa (bib16) 2006; 60
Serov, Scully, Sobin (bib14) 1973
Santini, Rainaldi, Indovina (bib40) 1999; 75
Suzuki (bib26) 1996; 61
Martin, Schilder (bib57) 2007; 25
Cowin, Rowlands, Hatsell (bib30) 2005; 17
Naora, Montell (bib3) 2005; 5
Burleson, Hansen, Skubitz (bib20) 2004; 21
Eisenkop, Spirtos, Lin (bib51) 2006; 103
Gumbiner (bib39) 1996; 84
Lin (10.1016/j.ygyno.2008.11.032_bib52) 2007; 46
Burleson (10.1016/j.ygyno.2008.11.032_bib23) 2004; 93
Puiffe (10.1016/j.ygyno.2008.11.032_bib24) 2007; 9
Jemal (10.1016/j.ygyno.2008.11.032_bib1) 2007; 57
Shield (10.1016/j.ygyno.2008.11.032_bib7) 2007; 6
Winter (10.1016/j.ygyno.2008.11.032_bib50) 2007; 25
Ivascu (10.1016/j.ygyno.2008.11.032_bib37) 2007; 31
Zietarska (10.1016/j.ygyno.2008.11.032_bib8) 2007; 46
Zhang (10.1016/j.ygyno.2008.11.032_bib47) 2008; 68
Burleson (10.1016/j.ygyno.2008.11.032_bib20) 2004; 21
10.1016/j.ygyno.2008.11.032_bib58
Sutherland (10.1016/j.ygyno.2008.11.032_bib42) 1971; 46
Zhu (10.1016/j.ygyno.2008.11.032_bib32) 2007; 86
Serov (10.1016/j.ygyno.2008.11.032_bib14) 1973
Burleson (10.1016/j.ygyno.2008.11.032_bib5) 2006; 4
Sundfeldt (10.1016/j.ygyno.2008.11.032_bib33) 2003; 202
Naora (10.1016/j.ygyno.2008.11.032_bib13) 2007; 9
Piccart (10.1016/j.ygyno.2008.11.032_bib54) 2001; 12
Sutherland (10.1016/j.ygyno.2008.11.032_bib43) 1976; 11
Ponti (10.1016/j.ygyno.2008.11.032_bib49) 2005; 65
Gumbiner (10.1016/j.ygyno.2008.11.032_bib39) 1996; 84
Kobayashi (10.1016/j.ygyno.2008.11.032_bib44) 1993; 90
Naora (10.1016/j.ygyno.2008.11.032_bib3) 2005; 5
Eisenkop (10.1016/j.ygyno.2008.11.032_bib51) 2006; 103
de Bree (10.1016/j.ygyno.2008.11.032_bib59) 2006; 32
Islam (10.1016/j.ygyno.2008.11.032_bib38) 2000; 78
Allen (10.1016/j.ygyno.2008.11.032_bib4) 1987; 55
Hagemann (10.1016/j.ygyno.2008.11.032_bib21) 2007; 6
Makhija (10.1016/j.ygyno.2008.11.032_bib46) 1999; 14
Shepherd (10.1016/j.ygyno.2008.11.032_bib18) 1989; 96
L'Esperance (10.1016/j.ygyno.2008.11.032_bib6) 2008; 9
(10.1016/j.ygyno.2008.11.032_bib2) 2006
Kantak (10.1016/j.ygyno.2008.11.032_bib22) 1998; 273
Dubeau (10.1016/j.ygyno.2008.11.032_bib10) 1999; 72
Auersperg (10.1016/j.ygyno.2008.11.032_bib12) 2001; 22
Santini (10.1016/j.ygyno.2008.11.032_bib40) 1999; 75
Sutherland (10.1016/j.ygyno.2008.11.032_bib45) 1970; 18
Guppy (10.1016/j.ygyno.2008.11.032_bib53) 2005; 17
Cannistra (10.1016/j.ygyno.2008.11.032_bib17) 2004; 351
Suzuki (10.1016/j.ygyno.2008.11.032_bib26) 1996; 61
Waleh (10.1016/j.ygyno.2008.11.032_bib25) 1994; 54
Patel (10.1016/j.ygyno.2008.11.032_bib31) 2003; 106
Wang (10.1016/j.ygyno.2008.11.032_bib55) 1985; 54
Colombo (10.1016/j.ygyno.2008.11.032_bib16) 2006; 60
Bapat (10.1016/j.ygyno.2008.11.032_bib48) 2005; 65
Cheng (10.1016/j.ygyno.2008.11.032_bib15) 2005; 11
Kim (10.1016/j.ygyno.2008.11.032_bib36) 2005; 118
Kostetskii (10.1016/j.ygyno.2008.11.032_bib28) 2005; 96
Veatch (10.1016/j.ygyno.2008.11.032_bib35) 1994; 58
Nishio (10.1016/j.ygyno.2008.11.032_bib56) 2007; 106
Martin (10.1016/j.ygyno.2008.11.032_bib57) 2007; 25
Auersperg (10.1016/j.ygyno.2008.11.032_bib9) 2008; 110
Cowin (10.1016/j.ygyno.2008.11.032_bib30) 2005; 17
Mueller-Klieser (10.1016/j.ygyno.2008.11.032_bib41) 1997; 273
Seidman (10.1016/j.ygyno.2008.11.032_bib11) 2004; 23
Morris (10.1016/j.ygyno.2008.11.032_bib29) 2006; 13
Ahmed (10.1016/j.ygyno.2008.11.032_bib19) 2007; 213
Aberle (10.1016/j.ygyno.2008.11.032_bib27) 1996; 61
Sarrio (10.1016/j.ygyno.2008.11.032_bib34) 2006; 37
References_xml – volume: 65
  start-page: 5506
  year: 2005
  end-page: 5511
  ident: bib49
  article-title: Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
  publication-title: Cancer Res.
  contributor:
    fullname: Coradini
– volume: 21
  start-page: 685
  year: 2004
  end-page: 697
  ident: bib20
  article-title: Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers
  publication-title: Clin. Exp. Metastasis
  contributor:
    fullname: Skubitz
– volume: 84
  start-page: 345
  year: 1996
  end-page: 357
  ident: bib39
  article-title: Cell adhesion: the molecular basis of tissue architecture and morphogenesis
  publication-title: Cell
  contributor:
    fullname: Gumbiner
– volume: 12
  start-page: 1195
  year: 2001
  end-page: 1203
  ident: bib54
  article-title: Current and future potential roles of the platinum drugs in the treatment of ovarian cancer
  publication-title: Ann. Oncol.
  contributor:
    fullname: Vermorken
– volume: 22
  start-page: 255
  year: 2001
  end-page: 288
  ident: bib12
  article-title: Ovarian surface epithelium: biology, endocrinology, and pathology
  publication-title: Endocr. Rev.
  contributor:
    fullname: Leung
– volume: 46
  start-page: 872
  year: 2007
  end-page: 885
  ident: bib8
  article-title: Molecular description of a 3D in vitro model for the study of epithelial ovarian cancer (EOC)
  publication-title: Mol. Carcinog.
  contributor:
    fullname: Provencher
– volume: 93
  start-page: 170
  year: 2004
  end-page: 181
  ident: bib23
  article-title: Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers
  publication-title: Gynecol. Oncol.
  contributor:
    fullname: Skubitz
– volume: 5
  start-page: 355
  year: 2005
  end-page: 366
  ident: bib3
  article-title: Ovarian cancer metastasis: integrating insights from disparate model organisms
  publication-title: Nat. Rev., Cancer
  contributor:
    fullname: Montell
– volume: 86
  start-page: 1011
  year: 2007
  end-page: 1019
  ident: bib32
  article-title: Tight junction formation in epithelial ovarian adenocarcinoma
  publication-title: Acta Obstet. Gynecol. Scand.
  contributor:
    fullname: Sundfeldt
– volume: 32
  start-page: 471
  year: 2006
  end-page: 482
  ident: bib59
  article-title: Treatment of ovarian cancer using intraperitoneal chemotherapy with taxanes: from laboratory bench to bedside
  publication-title: Cancer Treat. Rev.
  contributor:
    fullname: Beijnen
– volume: 61
  start-page: 531
  year: 1996
  end-page: 542
  ident: bib26
  article-title: Structural and functional diversity of cadherin superfamily: are new members of cadherin superfamily involved in signal transduction pathway?
  publication-title: J. Cell. Biochem.
  contributor:
    fullname: Suzuki
– volume: 106
  start-page: 172
  year: 2003
  end-page: 177
  ident: bib31
  article-title: Cadherin switching in ovarian cancer progression
  publication-title: Int. J. Cancer
  contributor:
    fullname: MacCalman
– volume: 273
  start-page: 16953
  year: 1998
  end-page: 16961
  ident: bib22
  article-title: E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Kramer
– volume: 6
  start-page: 11
  year: 2007
  ident: bib7
  article-title: alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis
  publication-title: J. Carcinog.
  contributor:
    fullname: Ahmed
– volume: 9
  start-page: 820
  year: 2007
  end-page: 829
  ident: bib24
  article-title: Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer
  publication-title: Neoplasia
  contributor:
    fullname: Tonin
– volume: 110
  start-page: 452
  year: 2008
  end-page: 454
  ident: bib9
  article-title: The origin of ovarian carcinomas: a developmental view
  publication-title: Gynecol. Oncol.
  contributor:
    fullname: Gilks
– volume: 11
  start-page: 87
  year: 1976
  end-page: 139
  ident: bib43
  article-title: Radiation response of multicell spheroids—an in vitro tumour model
  publication-title: Curr. Top Radiat. Res. Q.
  contributor:
    fullname: Durand
– volume: 90
  start-page: 3294
  year: 1993
  end-page: 3298
  ident: bib44
  article-title: Acquired multicellular-mediated resistance to alkylating agents in cancer
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  contributor:
    fullname: Kerbel
– volume: 18
  start-page: 491
  year: 1970
  end-page: 495
  ident: bib45
  article-title: A multi-component radiation survival curve using an in vitro tumour model
  publication-title: Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
  contributor:
    fullname: Kruuv
– volume: 106
  start-page: 342
  year: 2007
  end-page: 347
  ident: bib56
  article-title: Pilot study evaluating the efficacy and toxicity of irinotecan plus oral etoposide for platinum- and taxane-resistant epithelial ovarian cancer
  publication-title: Gynecol. Oncol.
  contributor:
    fullname: Ushijima
– volume: 9
  start-page: 99
  year: 2008
  ident: bib6
  article-title: Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids
  publication-title: BMC Genomics
  contributor:
    fullname: Bachvarov
– volume: 103
  start-page: 329
  year: 2006
  end-page: 335
  ident: bib51
  article-title: “Optimal” cytoreduction for advanced epithelial ovarian cancer: a commentary
  publication-title: Gynecol. Oncol.
  contributor:
    fullname: Lin
– year: 2006
  ident: bib2
  publication-title: Ovarian Cancer in Australia: an Overview
– volume: 6
  start-page: 1993
  year: 2007
  end-page: 2002
  ident: bib21
  article-title: Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis
  publication-title: Mol. Cancer Ther.
  contributor:
    fullname: Balkwill
– volume: 273
  start-page: C1109
  year: 1997
  end-page: C1123
  ident: bib41
  article-title: Three-dimensional cell cultures: from molecular mechanisms to clinical applications
  publication-title: Am. J. Physiol.
  contributor:
    fullname: Mueller-Klieser
– volume: 96
  start-page: 346
  year: 2005
  end-page: 354
  ident: bib28
  article-title: Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure
  publication-title: Circ. Res.
  contributor:
    fullname: Patel
– volume: 23
  start-page: 41
  year: 2004
  end-page: 44
  ident: bib11
  article-title: The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin
  publication-title: Int. J. Gynecol. Pathol.
  contributor:
    fullname: Ronnett
– volume: 54
  start-page: 838
  year: 1994
  end-page: 843
  ident: bib25
  article-title: Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma
  publication-title: Cancer Res.
  contributor:
    fullname: Sutherland
– volume: 17
  start-page: 399
  year: 2005
  end-page: 411
  ident: bib53
  article-title: Epithelial ovarian cancer: a review of current management
  publication-title: Clin. Oncol. (R. Coll. Radiol.)
  contributor:
    fullname: Rustin
– volume: 9
  start-page: 1
  year: 2007
  end-page: 12
  ident: bib13
  article-title: The heterogeneity of epithelial ovarian cancers: reconciling old and new paradigms
  publication-title: Expert Rev. Mol. Med.
  contributor:
    fullname: Naora
– volume: 60
  start-page: 159
  year: 2006
  end-page: 179
  ident: bib16
  article-title: Ovarian cancer
  publication-title: Crit. Rev., Oncol./Hematol.
  contributor:
    fullname: Sessa
– volume: 213
  start-page: 581
  year: 2007
  end-page: 588
  ident: bib19
  article-title: Epithelial–mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
  publication-title: J. Cell. Physiol.
  contributor:
    fullname: Quinn
– volume: 78
  start-page: 141
  year: 2000
  end-page: 150
  ident: bib38
  article-title: Vimentin expression in human squamous carcinoma cells: relationship with phenotypic changes and cadherin-based cell adhesion
  publication-title: J. Cell. Biochem.
  contributor:
    fullname: Johnson
– volume: 65
  start-page: 3025
  year: 2005
  end-page: 3029
  ident: bib48
  article-title: Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
  publication-title: Cancer Res.
  contributor:
    fullname: Kurrey
– volume: 31
  start-page: 1403
  year: 2007
  end-page: 1413
  ident: bib37
  article-title: Diversity of cell-mediated adhesions in breast cancer spheroids
  publication-title: Int. J. Oncol.
  contributor:
    fullname: Kubbies
– volume: 96
  start-page: 889
  year: 1989
  end-page: 892
  ident: bib18
  article-title: Revised FIGO staging for gynaecological cancer
  publication-title: Br. J. Obstet. Gynaecol.
  contributor:
    fullname: Shepherd
– volume: 25
  start-page: 2894
  year: 2007
  end-page: 2901
  ident: bib57
  article-title: Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition
  publication-title: J. Clin. Oncol.
  contributor:
    fullname: Schilder
– volume: 55
  start-page: 194
  year: 1987
  end-page: 208
  ident: bib4
  article-title: Isolation and morphologic characterization of human ovarian carcinoma cell clusters present in effusions
  publication-title: Exp. Cell Biol.
  contributor:
    fullname: Johnson
– volume: 11
  start-page: 531
  year: 2005
  end-page: 537
  ident: bib15
  article-title: Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
  publication-title: Nat. Med.
  contributor:
    fullname: Naora
– volume: 17
  start-page: 499
  year: 2005
  end-page: 508
  ident: bib30
  article-title: Cadherins and catenins in breast cancer
  publication-title: Curr. Opin. Cell Biol.
  contributor:
    fullname: Hatsell
– volume: 75
  start-page: 787
  year: 1999
  end-page: 799
  ident: bib40
  article-title: Multicellular tumour spheroids in radiation biology
  publication-title: Int. J. Radiat. Biol.
  contributor:
    fullname: Indovina
– volume: 118
  start-page: 3883
  year: 2005
  end-page: 3894
  ident: bib36
  article-title: Modulating the strength of cadherin adhesion: evidence for a novel adhesion complex
  publication-title: J. Cell. Sci.
  contributor:
    fullname: Johnson
– volume: 68
  start-page: 4311
  year: 2008
  end-page: 4320
  ident: bib47
  article-title: Identification and characterization of ovarian cancer-initiating cells from primary human tumors
  publication-title: Cancer Res.
  contributor:
    fullname: Schilder
– volume: 72
  start-page: 437
  year: 1999
  end-page: 442
  ident: bib10
  article-title: The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes?
  publication-title: Gynecol. Oncol.
  contributor:
    fullname: Dubeau
– volume: 57
  start-page: 43
  year: 2007
  end-page: 66
  ident: bib1
  article-title: Cancer statistics, 2007
  publication-title: CA Cancer J. Clin.
  contributor:
    fullname: Thun
– volume: 14
  start-page: 515
  year: 1999
  end-page: 521
  ident: bib46
  article-title: Taxol-induced bcl-2 phosphorylation in ovarian cancer cell monolayer and spheroids
  publication-title: Int. J. Oncol.
  contributor:
    fullname: Gercel-Taylor
– volume: 54
  start-page: 665
  year: 1985
  end-page: 697
  ident: bib55
  article-title: DNA topoisomerases
  publication-title: Annu. Rev. Biochem.
  contributor:
    fullname: Wang
– volume: 351
  start-page: 2519
  year: 2004
  end-page: 2529
  ident: bib17
  article-title: Cancer of the ovary
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Cannistra
– volume: 46
  start-page: 113
  year: 1971
  end-page: 120
  ident: bib42
  article-title: Growth of multicell spheroids in tissue culture as a model of nodular carcinomas
  publication-title: J. Natl. Cancer Inst.
  contributor:
    fullname: Inch
– volume: 25
  start-page: 3621
  year: 2007
  end-page: 3627
  ident: bib50
  article-title: Prognostic factors for stage III epithelial ovarian cancer: a gynecologic oncology group study
  publication-title: J. Clin. Oncol.
  contributor:
    fullname: Rose
– volume: 61
  start-page: 514
  year: 1996
  end-page: 523
  ident: bib27
  article-title: Cadherin–catenin complex: protein interactions and their implications for cadherin function
  publication-title: J. Cell. Biochem.
  contributor:
    fullname: Kemler
– volume: 202
  start-page: 89
  year: 2003
  end-page: 96
  ident: bib33
  article-title: Cell–cell adhesion in the normal ovary and ovarian tumors of epithelial origin; an exception to the rule
  publication-title: Mol. Cell. Endocrinol.
  contributor:
    fullname: Sundfeldt
– volume: 4
  start-page: 6
  year: 2006
  ident: bib5
  article-title: Disaggregation and invasion of ovarian carcinoma ascites spheroids
  publication-title: J. Transl. Med.
  contributor:
    fullname: Skubitz
– volume: 13
  start-page: 233
  year: 2006
  end-page: 247
  ident: bib29
  article-title: Junctional Adhesion Molecules (JAMs) are differentially expressed in fibroblasts and co-localize with ZO-1 to adherens-like junctions
  publication-title: Cell Adhes. Commun.
  contributor:
    fullname: Cunningham
– volume: 46
  start-page: 379
  year: 2007
  end-page: 388
  ident: bib52
  article-title: Management of relapsed/refractory epithelial ovarian cancer: current standards and novel approaches
  publication-title: Taiwan J. Obstet. Gynecol.
  contributor:
    fullname: Changchien
– volume: 58
  start-page: 393
  year: 1994
  end-page: 399
  ident: bib35
  article-title: Differential expression of the cell–cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells
  publication-title: Int. J. Cancer
  contributor:
    fullname: Ramakrishnan
– year: 1973
  ident: bib14
  article-title: Histological Typing of Ovarian Tumours
  contributor:
    fullname: Sobin
– volume: 37
  start-page: 1042
  year: 2006
  end-page: 1049
  ident: bib34
  article-title: Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas
  publication-title: Hum. Pathol.
  contributor:
    fullname: Hardisson
– volume: 75
  start-page: 787
  issue: 7
  year: 1999
  ident: 10.1016/j.ygyno.2008.11.032_bib40
  article-title: Multicellular tumour spheroids in radiation biology
  publication-title: Int. J. Radiat. Biol.
  doi: 10.1080/095530099139845
  contributor:
    fullname: Santini
– volume: 86
  start-page: 1011
  issue: 8
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib32
  article-title: Tight junction formation in epithelial ovarian adenocarcinoma
  publication-title: Acta Obstet. Gynecol. Scand.
  doi: 10.1080/00016340701463889
  contributor:
    fullname: Zhu
– volume: 110
  start-page: 452
  issue: 3
  year: 2008
  ident: 10.1016/j.ygyno.2008.11.032_bib9
  article-title: The origin of ovarian carcinomas: a developmental view
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2008.05.031
  contributor:
    fullname: Auersperg
– volume: 96
  start-page: 889
  issue: 8
  year: 1989
  ident: 10.1016/j.ygyno.2008.11.032_bib18
  article-title: Revised FIGO staging for gynaecological cancer
  publication-title: Br. J. Obstet. Gynaecol.
  doi: 10.1111/j.1471-0528.1989.tb03341.x
  contributor:
    fullname: Shepherd
– volume: 213
  start-page: 581
  issue: 3
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib19
  article-title: Epithelial–mesenchymal interconversions in normal ovarian surface epithelium and ovarian carcinomas: an exception to the norm
  publication-title: J. Cell. Physiol.
  doi: 10.1002/jcp.21240
  contributor:
    fullname: Ahmed
– volume: 6
  start-page: 1993
  issue: 7
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib21
  article-title: Ovarian cancer cell-derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-07-0118
  contributor:
    fullname: Hagemann
– volume: 18
  start-page: 491
  issue: 5
  year: 1970
  ident: 10.1016/j.ygyno.2008.11.032_bib45
  article-title: A multi-component radiation survival curve using an in vitro tumour model
  publication-title: Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med.
  doi: 10.1080/09553007014551401
  contributor:
    fullname: Sutherland
– volume: 61
  start-page: 531
  issue: 4
  year: 1996
  ident: 10.1016/j.ygyno.2008.11.032_bib26
  article-title: Structural and functional diversity of cadherin superfamily: are new members of cadherin superfamily involved in signal transduction pathway?
  publication-title: J. Cell. Biochem.
  doi: 10.1002/(SICI)1097-4644(19960616)61:4<531::AID-JCB6>3.0.CO;2-P
  contributor:
    fullname: Suzuki
– volume: 90
  start-page: 3294
  issue: 8
  year: 1993
  ident: 10.1016/j.ygyno.2008.11.032_bib44
  article-title: Acquired multicellular-mediated resistance to alkylating agents in cancer
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.90.8.3294
  contributor:
    fullname: Kobayashi
– volume: 202
  start-page: 89
  issue: 1–2
  year: 2003
  ident: 10.1016/j.ygyno.2008.11.032_bib33
  article-title: Cell–cell adhesion in the normal ovary and ovarian tumors of epithelial origin; an exception to the rule
  publication-title: Mol. Cell. Endocrinol.
  doi: 10.1016/S0303-7207(03)00068-6
  contributor:
    fullname: Sundfeldt
– year: 2006
  ident: 10.1016/j.ygyno.2008.11.032_bib2
– volume: 96
  start-page: 346
  issue: 3
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib28
  article-title: Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000156274.72390.2c
  contributor:
    fullname: Kostetskii
– volume: 9
  start-page: 1
  issue: 13
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib13
  article-title: The heterogeneity of epithelial ovarian cancers: reconciling old and new paradigms
  publication-title: Expert Rev. Mol. Med.
  doi: 10.1017/S1462399407000324
  contributor:
    fullname: Naora
– volume: 54
  start-page: 838
  issue: 3
  year: 1994
  ident: 10.1016/j.ygyno.2008.11.032_bib25
  article-title: Selective down-regulation of integrin receptors in spheroids of squamous cell carcinoma
  publication-title: Cancer Res.
  contributor:
    fullname: Waleh
– volume: 37
  start-page: 1042
  issue: 8
  year: 2006
  ident: 10.1016/j.ygyno.2008.11.032_bib34
  article-title: Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas
  publication-title: Hum. Pathol.
  doi: 10.1016/j.humpath.2006.03.003
  contributor:
    fullname: Sarrio
– volume: 273
  start-page: C1109
  issue: 4 Pt 1
  year: 1997
  ident: 10.1016/j.ygyno.2008.11.032_bib41
  article-title: Three-dimensional cell cultures: from molecular mechanisms to clinical applications
  publication-title: Am. J. Physiol.
  doi: 10.1152/ajpcell.1997.273.4.C1109
  contributor:
    fullname: Mueller-Klieser
– volume: 55
  start-page: 194
  issue: 4
  year: 1987
  ident: 10.1016/j.ygyno.2008.11.032_bib4
  article-title: Isolation and morphologic characterization of human ovarian carcinoma cell clusters present in effusions
  publication-title: Exp. Cell Biol.
  contributor:
    fullname: Allen
– volume: 106
  start-page: 172
  issue: 2
  year: 2003
  ident: 10.1016/j.ygyno.2008.11.032_bib31
  article-title: Cadherin switching in ovarian cancer progression
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.11086
  contributor:
    fullname: Patel
– volume: 65
  start-page: 5506
  issue: 13
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib49
  article-title: Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-0626
  contributor:
    fullname: Ponti
– volume: 6
  start-page: 11
  issue: 1
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib7
  article-title: alpha2beta1 integrin affects metastatic potential of ovarian carcinoma spheroids by supporting disaggregation and proteolysis
  publication-title: J. Carcinog.
  doi: 10.1186/1477-3163-6-11
  contributor:
    fullname: Shield
– volume: 21
  start-page: 685
  issue: 8
  year: 2004
  ident: 10.1016/j.ygyno.2008.11.032_bib20
  article-title: Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers
  publication-title: Clin. Exp. Metastasis
  doi: 10.1007/s10585-004-5768-5
  contributor:
    fullname: Burleson
– volume: 46
  start-page: 872
  issue: 10
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib8
  article-title: Molecular description of a 3D in vitro model for the study of epithelial ovarian cancer (EOC)
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20315
  contributor:
    fullname: Zietarska
– ident: 10.1016/j.ygyno.2008.11.032_bib58
– volume: 60
  start-page: 159
  issue: 2
  year: 2006
  ident: 10.1016/j.ygyno.2008.11.032_bib16
  article-title: Ovarian cancer
  publication-title: Crit. Rev., Oncol./Hematol.
  doi: 10.1016/j.critrevonc.2006.03.004
  contributor:
    fullname: Colombo
– volume: 22
  start-page: 255
  issue: 2
  year: 2001
  ident: 10.1016/j.ygyno.2008.11.032_bib12
  article-title: Ovarian surface epithelium: biology, endocrinology, and pathology
  publication-title: Endocr. Rev.
  contributor:
    fullname: Auersperg
– volume: 57
  start-page: 43
  issue: 1
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib1
  article-title: Cancer statistics, 2007
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/canjclin.57.1.43
  contributor:
    fullname: Jemal
– volume: 11
  start-page: 531
  issue: 5
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib15
  article-title: Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
  publication-title: Nat. Med.
  doi: 10.1038/nm1230
  contributor:
    fullname: Cheng
– volume: 25
  start-page: 2894
  issue: 20
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib57
  article-title: Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2007.11.1088
  contributor:
    fullname: Martin
– volume: 23
  start-page: 41
  issue: 1
  year: 2004
  ident: 10.1016/j.ygyno.2008.11.032_bib11
  article-title: The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin
  publication-title: Int. J. Gynecol. Pathol.
  doi: 10.1097/01.pgp.0000101080.35393.16
  contributor:
    fullname: Seidman
– volume: 9
  start-page: 820
  issue: 10
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib24
  article-title: Characterization of ovarian cancer ascites on cell invasion, proliferation, spheroid formation, and gene expression in an in vitro model of epithelial ovarian cancer
  publication-title: Neoplasia
  doi: 10.1593/neo.07472
  contributor:
    fullname: Puiffe
– volume: 17
  start-page: 499
  issue: 5
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib30
  article-title: Cadherins and catenins in breast cancer
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2005.08.014
  contributor:
    fullname: Cowin
– volume: 4
  start-page: 6
  year: 2006
  ident: 10.1016/j.ygyno.2008.11.032_bib5
  article-title: Disaggregation and invasion of ovarian carcinoma ascites spheroids
  publication-title: J. Transl. Med.
  doi: 10.1186/1479-5876-4-6
  contributor:
    fullname: Burleson
– year: 1973
  ident: 10.1016/j.ygyno.2008.11.032_bib14
  contributor:
    fullname: Serov
– volume: 93
  start-page: 170
  issue: 1
  year: 2004
  ident: 10.1016/j.ygyno.2008.11.032_bib23
  article-title: Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2003.12.034
  contributor:
    fullname: Burleson
– volume: 46
  start-page: 379
  issue: 4
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib52
  article-title: Management of relapsed/refractory epithelial ovarian cancer: current standards and novel approaches
  publication-title: Taiwan J. Obstet. Gynecol.
  doi: 10.1016/S1028-4559(08)60007-8
  contributor:
    fullname: Lin
– volume: 78
  start-page: 141
  issue: 1
  year: 2000
  ident: 10.1016/j.ygyno.2008.11.032_bib38
  article-title: Vimentin expression in human squamous carcinoma cells: relationship with phenotypic changes and cadherin-based cell adhesion
  publication-title: J. Cell. Biochem.
  doi: 10.1002/(SICI)1097-4644(20000701)78:1<141::AID-JCB13>3.0.CO;2-R
  contributor:
    fullname: Islam
– volume: 106
  start-page: 342
  issue: 2
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib56
  article-title: Pilot study evaluating the efficacy and toxicity of irinotecan plus oral etoposide for platinum- and taxane-resistant epithelial ovarian cancer
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2007.03.036
  contributor:
    fullname: Nishio
– volume: 65
  start-page: 3025
  issue: 8
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib48
  article-title: Stem and progenitor-like cells contribute to the aggressive behavior of human epithelial ovarian cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-3931
  contributor:
    fullname: Bapat
– volume: 12
  start-page: 1195
  issue: 9
  year: 2001
  ident: 10.1016/j.ygyno.2008.11.032_bib54
  article-title: Current and future potential roles of the platinum drugs in the treatment of ovarian cancer
  publication-title: Ann. Oncol.
  doi: 10.1023/A:1012259625746
  contributor:
    fullname: Piccart
– volume: 273
  start-page: 16953
  issue: 27
  year: 1998
  ident: 10.1016/j.ygyno.2008.11.032_bib22
  article-title: E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.27.16953
  contributor:
    fullname: Kantak
– volume: 17
  start-page: 399
  issue: 6
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib53
  article-title: Epithelial ovarian cancer: a review of current management
  publication-title: Clin. Oncol. (R. Coll. Radiol.)
  doi: 10.1016/j.clon.2005.05.009
  contributor:
    fullname: Guppy
– volume: 351
  start-page: 2519
  issue: 24
  year: 2004
  ident: 10.1016/j.ygyno.2008.11.032_bib17
  article-title: Cancer of the ovary
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra041842
  contributor:
    fullname: Cannistra
– volume: 61
  start-page: 514
  issue: 4
  year: 1996
  ident: 10.1016/j.ygyno.2008.11.032_bib27
  article-title: Cadherin–catenin complex: protein interactions and their implications for cadherin function
  publication-title: J. Cell. Biochem.
  doi: 10.1002/(SICI)1097-4644(19960616)61:4<514::AID-JCB4>3.0.CO;2-R
  contributor:
    fullname: Aberle
– volume: 103
  start-page: 329
  issue: 1
  year: 2006
  ident: 10.1016/j.ygyno.2008.11.032_bib51
  article-title: “Optimal” cytoreduction for advanced epithelial ovarian cancer: a commentary
  publication-title: Gynecol. Oncol.
  doi: 10.1016/j.ygyno.2006.07.004
  contributor:
    fullname: Eisenkop
– volume: 58
  start-page: 393
  issue: 3
  year: 1994
  ident: 10.1016/j.ygyno.2008.11.032_bib35
  article-title: Differential expression of the cell–cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.2910580315
  contributor:
    fullname: Veatch
– volume: 31
  start-page: 1403
  issue: 6
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib37
  article-title: Diversity of cell-mediated adhesions in breast cancer spheroids
  publication-title: Int. J. Oncol.
  contributor:
    fullname: Ivascu
– volume: 5
  start-page: 355
  issue: 5
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib3
  article-title: Ovarian cancer metastasis: integrating insights from disparate model organisms
  publication-title: Nat. Rev., Cancer
  doi: 10.1038/nrc1611
  contributor:
    fullname: Naora
– volume: 54
  start-page: 665
  year: 1985
  ident: 10.1016/j.ygyno.2008.11.032_bib55
  article-title: DNA topoisomerases
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.bi.54.070185.003313
  contributor:
    fullname: Wang
– volume: 11
  start-page: 87
  issue: 1
  year: 1976
  ident: 10.1016/j.ygyno.2008.11.032_bib43
  article-title: Radiation response of multicell spheroids—an in vitro tumour model
  publication-title: Curr. Top Radiat. Res. Q.
  contributor:
    fullname: Sutherland
– volume: 14
  start-page: 515
  issue: 3
  year: 1999
  ident: 10.1016/j.ygyno.2008.11.032_bib46
  article-title: Taxol-induced bcl-2 phosphorylation in ovarian cancer cell monolayer and spheroids
  publication-title: Int. J. Oncol.
  contributor:
    fullname: Makhija
– volume: 68
  start-page: 4311
  issue: 11
  year: 2008
  ident: 10.1016/j.ygyno.2008.11.032_bib47
  article-title: Identification and characterization of ovarian cancer-initiating cells from primary human tumors
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-0364
  contributor:
    fullname: Zhang
– volume: 72
  start-page: 437
  issue: 3
  year: 1999
  ident: 10.1016/j.ygyno.2008.11.032_bib10
  article-title: The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes?
  publication-title: Gynecol. Oncol.
  doi: 10.1006/gyno.1998.5275
  contributor:
    fullname: Dubeau
– volume: 46
  start-page: 113
  issue: 1
  year: 1971
  ident: 10.1016/j.ygyno.2008.11.032_bib42
  article-title: Growth of multicell spheroids in tissue culture as a model of nodular carcinomas
  publication-title: J. Natl. Cancer Inst.
  contributor:
    fullname: Sutherland
– volume: 25
  start-page: 3621
  issue: 24
  year: 2007
  ident: 10.1016/j.ygyno.2008.11.032_bib50
  article-title: Prognostic factors for stage III epithelial ovarian cancer: a gynecologic oncology group study
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2006.10.2517
  contributor:
    fullname: Winter
– volume: 9
  start-page: 99
  issue: 1
  year: 2008
  ident: 10.1016/j.ygyno.2008.11.032_bib6
  article-title: Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-9-99
  contributor:
    fullname: L'Esperance
– volume: 84
  start-page: 345
  issue: 3
  year: 1996
  ident: 10.1016/j.ygyno.2008.11.032_bib39
  article-title: Cell adhesion: the molecular basis of tissue architecture and morphogenesis
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81279-9
  contributor:
    fullname: Gumbiner
– volume: 32
  start-page: 471
  issue: 6
  year: 2006
  ident: 10.1016/j.ygyno.2008.11.032_bib59
  article-title: Treatment of ovarian cancer using intraperitoneal chemotherapy with taxanes: from laboratory bench to bedside
  publication-title: Cancer Treat. Rev.
  doi: 10.1016/j.ctrv.2006.07.006
  contributor:
    fullname: de Bree
– volume: 13
  start-page: 233
  issue: 4
  year: 2006
  ident: 10.1016/j.ygyno.2008.11.032_bib29
  article-title: Junctional Adhesion Molecules (JAMs) are differentially expressed in fibroblasts and co-localize with ZO-1 to adherens-like junctions
  publication-title: Cell Adhes. Commun.
  doi: 10.1080/15419060600877978
  contributor:
    fullname: Morris
– volume: 118
  start-page: 3883
  issue: Pt 17
  year: 2005
  ident: 10.1016/j.ygyno.2008.11.032_bib36
  article-title: Modulating the strength of cadherin adhesion: evidence for a novel adhesion complex
  publication-title: J. Cell. Sci.
  doi: 10.1242/jcs.02508
  contributor:
    fullname: Kim
SSID ssj0003012
Score 2.4893992
SecondaryResourceType review_article
Snippet Abstract Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes...
Epithelial ovarian cancer (EOC) has a relatively high mortality rate (∼ 55%). One of the presiding causes is that the current chemotherapeutic regimes are...
Epithelial ovarian cancer (EOC) has a relatively high mortality rate ( approximately 55%). One of the presiding causes is that the current chemotherapeutic...
SourceID proquest
crossref
pubmed
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 143
SubjectTerms Chemo-resistance
Chemotherapy
Epithelial ovarian cancer
Female
Hematology, Oncology and Palliative Medicine
Humans
Metastasis
Neoplasm Metastasis
Obstetrics and Gynecology
Ovarian Neoplasms - pathology
Spheroids
Spheroids, Cellular - pathology
Title Multicellular spheroids in ovarian cancer metastases: Biology and pathology
URI https://www.clinicalkey.es/playcontent/1-s2.0-S0090825808009748
https://dx.doi.org/10.1016/j.ygyno.2008.11.032
https://www.ncbi.nlm.nih.gov/pubmed/19135710
https://search.proquest.com/docview/67055734
Volume 113
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB5EQbyIb9dnDh6tpk3Tbr2JKKvL7kFc9BbSPGQFW7GrsBd_u5m0VUTWg6fSQpt2Jpl8aeb7BuCIaa1oauIgs1QFbsbXQaZTHvA8S63Dr3ni6WODYdIbxTcP_GEOLlouDKZVNrG_juk-WjdXThtrnr6Mx8jxxXLdHIURqXsqEn5jTrGKwcnHd5qH68C1YrinTPNuqzzkc7ymj9OirBMqUcqTRbNmp1no089CVyuw3MBHcl6_4SrMmWINFgfNBvk69D2hFv_GY3opqVA0oBzriowLUr67dbEsiEJHv5JnM5EOGlamOiN1RcopkYUmWKPYn23A6Ory7qIXNPUSAhWn3QkSoaVhucadUJ7TSLJQuiHmEIqWsTQyZkra3GqVG5mY1FBqo8ThAxVbZnXG2CbMF2VhtoFwGSmWdJVBwNXlUa4TZbmiOlQ25GnUgePWTuKllsUQbb7Yk_BmrQtcuuWFM2sH0taWomV8uhhlqmbAVCIUVSSo-OXUDiRfd_7oF8KF_L-bPGx9JtyIQcPLwpRvlUhQQChlcQe2ald-f0EWMu4g185_G92FpXa3iYZ7MD95fTP7DrRM8gPfKw9g4fy63xvisX973_8E6GDtsw
link.rule.ids 314,780,784,4502,24116,27924,27925,45585,45679
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB58gHoR367PHDxaTJumab2JKKvr7knBW0jzkBVsF7sK---d9KGI6MFjC23amcnkazPfNwAnzBhNhY2DzFEd4IpvgswIHvA8Ew7xa57U9LHhKOk_xLeP_HEOLjsujC-rbHN_k9PrbN2eOWuteTYZjz3H17fr5l4YkeJd03lYRDQgMLQXL24G_dFnQsYYbkTDa9Y0TzvxobrMa_Y0K8qmptKrebLotwXqNwBaL0TXa7DaIkhy0TzkOszZYgOWhu0e-SYMak6t_yHvK0xJ5XUDyrGpyLgg5Tt-GquCaO_rV_JipwrRYWWrc9I0pZwRVRji2xTXR1vwcH11f9kP2pYJgY5FOvVcaGVZbvxmKM9ppFiocJYhSDEqVlbFTCuXO6NzqxIrLKUuShAi6NgxZzLGtmGhKAu7C4SrSLMk1dZjrpRHuUm045qaULuQi6gHp52d5KRRxpBdydizrM3a9LjELww0aw9EZ0vZkT4xTdmqnTOVDGUVSSp_-LUHyeeV30JDYtb_e8jjzmcSJ403vCps-VbJxGsICRb3YKdx5dcbZCHjiLr2_jvoMSz374d38u5mNNiHlW7ziYYHsDB9fbOHiGGm-VEbox_G6-7R
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Multicellular+spheroids+in+ovarian+cancer+metastases%3A+Biology+and+pathology&rft.jtitle=Gynecologic+oncology&rft.au=Shield%2C+Kristy&rft.au=Ackland%2C+M+Leigh&rft.au=Ahmed%2C+Nuzhat&rft.au=Rice%2C+Gregory+E&rft.date=2009-04-01&rft.eissn=1095-6859&rft.volume=113&rft.issue=1&rft.spage=143&rft_id=info:doi/10.1016%2Fj.ygyno.2008.11.032&rft_id=info%3Apmid%2F19135710&rft.externalDocID=19135710
thumbnail_m http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00908258%2FS0090825809X0003X%2Fcov150h.gif