A Dual Role of Heme Oxygenase-1 in Cancer Cells

• Published in: International journal of molecular sciences Vol. 20; no. 1; p. 39
• Main Authors: Chiang, Shih-Kai, Chen, Shuen-Ei, Chang, Ling-Chu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.12.2018; MDPI
• Subjects: Animals; Apoptosis; Cancer therapies; Cell Death; Cell growth; Cell Line, Tumor; Disease Models, Animal; Drug Therapy; Ferroptosis; Glutathione; Heme - metabolism; Heme Oxygenase-1 - metabolism; Humans; Iron - metabolism; Lipid Peroxidation; Neoplasms - metabolism; Oxidation; Reactive Oxygen Species - metabolism; Review; Xenograft Model Antitumor Assays; iron; ferroptosis; heme oxygenase-1; chemotherapy; glutathione; reactive oxygen species

Heme oxygenase (HO)-1 is known to metabolize heme into biliverdin/bilirubin, carbon monoxide, and ferrous iron, and it has been suggested to demonstrate cytoprotective effects against various stress-related conditions. HO-1 is commonly regarded as a survival molecule, exerting an important role in c...