Estrogen and Tibolone Metabolite Levels in Blood and Breast Tissue of Postmenopausal Women Recently Diagnosed With Early-Stage Breast Cancer and Treated With Tibolone or Placebo for 14 Days

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Vol. 14; no. 2; pp. 151 - 159
• Main Authors: Kloosterboer, Helenius J., Löfgren, Lars, von Schoulz, Eva, von Schoultz, Bo, Verheul, Herman A. M.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA Sage Publications 01.02.2007; Sage
• Subjects: Aged; Androstenols - blood; Biological and medical sciences; Breast - metabolism; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - surgery; Chromatography, Liquid; Double-Blind Method; Estradiol - blood; Estradiol - metabolism; Estrenes - blood; Estrenes - metabolism; Estrone - analogs & derivatives; Estrone - blood; Estrone - metabolism; Female; Gas Chromatography-Mass Spectrometry; Gynecology. Andrology. Obstetrics; Humans; Mammary gland diseases; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Neoplasm Staging; Norpregnenes - analysis; Norpregnenes - blood; Norpregnenes - metabolism; Norpregnenes - therapeutic use; Postmenopause - blood; Postmenopause - metabolism; Selective Estrogen Receptor Modulators - metabolism; Selective Estrogen Receptor Modulators - therapeutic use; Tandem Mass Spectrometry; Tissue Distribution; Tumors; tissue level; estrogenmetabolites; breast; Tibolonemetabolites; postmenopausal; Metabolite; Tibolone; Estrogen; Early stage; estrogen metabolites; Blood; Tibolone metabolites; Postmenopause; Adult; Female; Diagnosis; Mammary gland; Woman; Human; Corticosteroid; Gynecology; Breast cancer; Malignant tumor; Obstetrics; Ovarian hormone; Mammary gland diseases; Treatment; Placebo; Breast; Sex steroid hormone

Unlike estrogens plus progestagens, tibolone, a selective tissue estrogenic activity regulator, does not increase breast tenderness and mammographic density. To elucidate this, serum and breast levels of tibolone and estrogenic metabolites are measured. Postmenopausal women (n = 102) with early-stag...