Autophagy Stimulation as a Potential Strategy Against Intestinal Fibrosis

• Published in: Cells (Basel, Switzerland) Vol. 8; no. 9; p. 1078
• Main Authors: Cosin-Roger, Jesus, Canet, Francisco, Macias-Ceja, Dulce C., Gisbert-Ferrándiz, Laura, Ortiz-Masiá, Dolores, Esplugues, Juan V., Alós, Rafael, Navarro, Francisco, Barrachina, María D., Calatayud, Sara
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.09.2019; MDPI
• Subjects: Animal models; Animals; Autophagy; Autophagy - drug effects; Brief Report; Colitis; Collagen; Collagen - metabolism; Colon; Crohn Disease - complications; Crohn's disease; Cytokines; Disease Models, Animal; Fibroblasts; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis; Fibrosis - drug therapy; Gene expression; Immunosuppressive Agents - pharmacology; Inflammation; Inflammation - drug therapy; Inflammation - immunology; Inflammatory bowel diseases; intestinal fibrosis; Intestine; Intestines - pathology; Mice; Mice, Inbred C57BL; Phagocytosis; Proteins; Sirolimus - pharmacology; Software; Variance analysis; Spain; intestinal fibrosis; inflammation; autophagy

We recently observed reduced autophagy in Crohn’s disease patients and an anti-inflammatory effect of autophagy stimulation in murine colitis, but both anti- and pro-fibrotic effects are associated with autophagy stimulation in different tissues, and fibrosis is a frequent complication of Crohn’s di...