Prevention of Gastric Cancer: Eradication of Helicobacter Pylori and Beyond

Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed t...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 18; no. 8; p. 1699
Main Authors Tsukamoto, Tetsuya, Nakagawa, Mitsuru, Kiriyama, Yuka, Toyoda, Takeshi, Cao, Xueyuan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 03.08.2017
MDPI
Subjects
Animals
Bacteria
Gastric cancer
Helicobacter Infections - drug therapy
Helicobacter Infections - metabolism
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori
Humans
Public health
Review
Stomach Neoplasms - metabolism
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Stomach Neoplasms - prevention & control
chronic atrophic gastritis
chemoprevention
Helicobacter pylori
intestinal metaplasia
eradication
Online AccessGet full text

Cover

Abstract Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of H. pylori eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.
AbstractList Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of H. pylori eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of H. pylori eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of H. pylori eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H. pylori reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of H. pylori eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.
Author Nakagawa, Mitsuru
Kiriyama, Yuka
Tsukamoto, Tetsuya
Cao, Xueyuan
Toyoda, Takeshi
AuthorAffiliation 2 Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan; t-toyoda@nihs.go.jp
1 Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan; nakaga1@fujita-hu.ac.jp (M.N.); ykiri@fujita-hu.ac.jp (Y.K.)
3 Department of Gastric and Colorectal Surgery, Jilin University, Changchun 130000, China; caoxueyuan19680414@yahoo.co.jp
AuthorAffiliation_xml – name: 1 Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan; nakaga1@fujita-hu.ac.jp (M.N.); ykiri@fujita-hu.ac.jp (Y.K.)
– name: 3 Department of Gastric and Colorectal Surgery, Jilin University, Changchun 130000, China; caoxueyuan19680414@yahoo.co.jp
– name: 2 Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan; t-toyoda@nihs.go.jp
Author_xml – sequence: 1
  givenname: Tetsuya
  surname: Tsukamoto
  fullname: Tsukamoto, Tetsuya
– sequence: 2
  givenname: Mitsuru
  surname: Nakagawa
  fullname: Nakagawa, Mitsuru
– sequence: 3
  givenname: Yuka
  surname: Kiriyama
  fullname: Kiriyama, Yuka
– sequence: 4
  givenname: Takeshi
  surname: Toyoda
  fullname: Toyoda, Takeshi
– sequence: 5
  givenname: Xueyuan
  surname: Cao
  fullname: Cao, Xueyuan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28771198$$D View this record in MEDLINE/PubMed
BookMark eNptkUlLBDEQhYMoLqM3z9LgxYOjWXqLB0GHcUFBD3oO6eqKZuhJNOkR5t8bl5FRPFVBffV49WqLrDrvkJBdRo-EkPTYTqaR1bRmpZQrZJPlnA8pLavVpX6DbMU4oZQLXsh1ssHrqmJM1pvk5j7gG7reepd5k13q2AcL2Ug7wHCSjYNuLejF-Ao7C77R0GPI7uedDzbTrs3Oce5du03WjO4i7nzXAXm8GD-Mroa3d5fXo7PbIeRV3Q953ZhS8wZaSls0rMl5pdEYWQoJ6SQhOZicllgaEMByqFutqUFe0RK4bsSAnH7pvsyaKbaQ7AfdqZdgpzrMlddW_Z44-6ye_JsqiioFJZPAwbdA8K8zjL2a2gjYddqhn0XFJC8SxmmR0P0_6MTPgkvnJUpIKQrOPgT3lh39WFnknAD-BUDwMQY0Cmz_GWsyaDvFqPp4plp-Zlo6_LO00P0XfwfGgaGM
CitedBy_id crossref_primary_10_1155_2020_3018326
crossref_primary_10_1293_tox_2019_0007
crossref_primary_10_1186_s12935_021_02140_2
crossref_primary_10_1002_cam4_1615
crossref_primary_10_1080_17474124_2021_1845140
crossref_primary_10_4103_njcp_njcp_302_20
crossref_primary_10_1016_j_sjbs_2018_02_016
crossref_primary_10_1155_2022_4862376
crossref_primary_10_1016_j_giec_2021_03_006
crossref_primary_10_3390_ijms21072544
crossref_primary_10_3748_wjg_v25_i46_6743
crossref_primary_10_1155_2020_5197201
crossref_primary_10_1016_j_jep_2021_114855
crossref_primary_10_34172_mejdd_2022_285
crossref_primary_10_1093_gastro_goac064
crossref_primary_10_3389_fmicb_2022_950325
crossref_primary_10_1080_07853890_2024_2424513
crossref_primary_10_5937_SestrViz2109010M
crossref_primary_10_3390_jcm11175086
crossref_primary_10_7759_cureus_31502
crossref_primary_10_1007_s00432_023_05537_w
crossref_primary_10_1155_2022_7385344
crossref_primary_10_1142_S0192415X18500593
crossref_primary_10_31631_2073_3046_2025_24_1_90_100
crossref_primary_10_1155_2022_6734105
crossref_primary_10_1002_ags3_12517
crossref_primary_10_3748_wjg_v26_i13_1382
crossref_primary_10_34172_aim_2020_28
crossref_primary_10_1038_s41598_023_44470_3
crossref_primary_10_1002_jcp_29203
crossref_primary_10_1556_030_2022_01682
crossref_primary_10_1002_ijc_33158
crossref_primary_10_1111_hel_12810
crossref_primary_10_1186_s12957_021_02343_x
crossref_primary_10_3390_ijms21093115
crossref_primary_10_3390_toxins11020091
crossref_primary_10_54393_pjhs_v3i05_192
crossref_primary_10_3748_wjg_v30_i6_556
crossref_primary_10_1136_bmjgast_2019_000330
crossref_primary_10_1186_s40360_024_00731_z
crossref_primary_10_1016_j_flm_2019_08_001
crossref_primary_10_22516_25007440_858
crossref_primary_10_1007_s10120_020_01077_1
crossref_primary_10_51821_84_1_208
crossref_primary_10_1021_acsomega_0c04763
crossref_primary_10_3389_fmicb_2021_674560
Cites_doi 10.1016/S0016-5085(98)70143-X
10.1002/ijc.23245
10.1056/NEJM199110173251603
10.1371/journal.pone.0121841
10.1038/sj.emboj.7600170
10.1111/j.1440-1746.2009.05995.x
10.1056/NEJM199110173251604
10.1289/ehp.9298207
10.1179/joc.2001.13.6.611
10.7326/0003-4819-116-9-705
10.1016/j.phymed.2009.09.010
10.1007/BF00115637
10.3892/or.2016.4717
10.1007/s10120-007-0420-0
10.1128/AAC.00642-06
10.1111/j.1440-1746.1996.tb00312.x
10.21873/anticanres.11306
10.1093/jjco/hyl112
10.1053/j.gastro.2006.07.014
10.1093/jnci/djj264
10.1007/s10120-015-0479-y
10.1007/BF02347631
10.1093/jnci/55.1.101
10.2188/jea.10.310
10.1111/j.1349-7006.2006.00135.x
10.1002/ijc.24862
10.1111/j.1349-7006.2007.00416.x
10.1111/j.1349-7006.2010.01743.x
10.1007/s00281-012-0357-1
10.1136/gut.2003.034629
10.1016/S0016-5085(97)70155-0
10.1136/bmj.302.6788.1302
10.1016/S0016-5085(00)70412-4
10.1136/gut.2005.072009
10.1002/ijc.24591
10.1056/NEJMoa001999
10.1111/hel.12132
10.1053/j.gastro.2005.12.038
10.1007/s10120-011-0041-5
10.1126/science.7886456
10.1007/BF02936365
10.1016/j.mehy.2013.01.023
10.1111/j.1523-5378.1996.tb00008.x
10.1007/s00535-010-0335-0
10.1128/mBio.02321-16
10.3892/mmr.2014.2704
10.1046/j.1365-2036.2000.00752.x
10.1111/j.1349-7006.2002.tb01267.x
10.1016/j.prp.2011.12.002
10.1016/S0140-6736(84)91816-6
10.1016/j.tim.2005.08.002
10.1126/science.1099250
10.1002/cbf.1148
10.1128/iai.55.11.2789-2796.1987
10.1038/216943a0
10.1016/j.ccr.2008.10.011
10.1111/j.1572-0241.2002.05663.x
10.18632/oncotarget.12467
10.1111/j.1349-7006.2002.tb01209.x
10.1111/j.1365-2036.2005.02360.x
10.1001/jama.291.2.187
10.1016/S0016-5085(98)70422-6
10.1136/gut.33.1.16
10.1136/gut.36.2.198
10.1016/S0891-5849(02)00868-7
10.1093/jjco/hyi114
10.1038/nrmicro1658
10.1046/j.1440-1746.2000.02266.x
10.1111/j.1349-7006.1998.tb00535.x
10.1159/000100503
10.1046/j.1365-2036.2002.01311.x
10.1097/00042737-200608000-00010
10.1016/0140-6736(93)90938-D
10.1111/j.1349-7006.1992.tb01999.x
10.1038/ajg.2013.404
10.1111/hel.12243
10.1038/35083631
10.1158/1055-9965.EPI-06-1009
10.1023/A:1008890529261
10.1002/ijc.10649
10.1016/S0140-6736(08)61159-9
10.1371/journal.pone.0120938
10.1111/j.1349-7006.2003.tb01409.x
10.1016/j.bbrc.2005.06.132
10.1111/cas.12901
10.1093/ije/25.3.494
10.1007/s00535-011-0504-9
10.1007/s10120-015-0462-7
10.1111/j.1349-7006.1993.tb02831.x
10.1111/j.1349-7006.2003.tb01426.x
10.1093/jac/dkg057
10.1093/carcin/20.4.669
10.1128/IAI.72.8.4668-4679.2004
10.1016/0016-5085(90)91156-Z
10.1093/jac/dkg366
10.1002/ijc.21810
10.1016/S0140-6736(95)91084-0
10.1128/iai.58.8.2606-2612.1990
10.1080/09637486.2016.1198892
10.1111/j.1349-7006.2008.00983.x
10.1016/j.jgr.2013.11.005
10.1158/1055-9965.EPI-15-0578
10.4236/ojpathology.2016.62012
10.2183/pjab.90.251
10.1136/gutjnl-2012-302240
10.1056/NEJM199405053301803
ContentType Journal Article
Copyright Copyright MDPI AG 2017
2017 by the authors. 2017
Copyright_xml – notice: Copyright MDPI AG 2017
– notice: 2017 by the authors. 2017
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOI 10.3390/ijms18081699
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni)
Medical Database
Research Library
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central China
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE
Publicly Available Content Database

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Public Health
EISSN 1422-0067
ExternalDocumentID PMC5578089
28771198
10_3390_ijms18081699
Genre Journal Article
Review
GroupedDBID ---
29J
2WC
53G
5GY
5VS
7X7
88E
8FE
8FG
8FH
8FI
8FJ
8G5
A8Z
AADQD
AAFWJ
AAHBH
AAYXX
ABDBF
ABUWG
ACGFO
ACIHN
ACIWK
ACPRK
ACUHS
ADBBV
ADRAZ
AEAQA
AENEX
AFKRA
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
CITATION
CS3
D1I
DIK
DU5
DWQXO
E3Z
EBD
EBS
EJD
ESX
F5P
FRP
FYUFA
GNUQQ
GUQSH
GX1
HH5
HMCUK
HYE
IAO
IHR
IPNFZ
ITC
KQ8
LK8
M1P
M2O
M48
MODMG
O5R
O5S
OK1
OVT
P2P
PHGZM
PHGZT
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNS
RPM
TR2
TUS
UKHRP
~8M
3V.
ABJCF
BBNVY
BHPHI
CGR
CUY
CVF
ECM
EIF
GROUPED_DOAJ
HCIFZ
KB.
M7P
M~E
NPM
PDBOC
7XB
8FK
K9.
MBDVC
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
PRINS
Q9U
7X8
5PM
ID FETCH-LOGICAL-c478t-28bf6a2bcd00def1b427aeff9639c339392cf406e6fc3c14c8daa0fe2706c2ab3
IEDL.DBID M48
ISSN 1422-0067
1661-6596
IngestDate Thu Aug 21 17:28:39 EDT 2025
Fri Jul 11 06:43:25 EDT 2025
Fri Jul 25 19:56:33 EDT 2025
Wed Feb 19 02:40:42 EST 2025
Tue Jul 01 03:30:03 EDT 2025
Thu Apr 24 23:01:30 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords chronic atrophic gastritis
chemoprevention
Helicobacter pylori
intestinal metaplasia
eradication
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c478t-28bf6a2bcd00def1b427aeff9639c339392cf406e6fc3c14c8daa0fe2706c2ab3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/ijms18081699
PMID 28771198
PQID 1939935219
PQPubID 2032341
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_5578089
proquest_miscellaneous_1925893205
proquest_journals_1939935219
pubmed_primary_28771198
crossref_citationtrail_10_3390_ijms18081699
crossref_primary_10_3390_ijms18081699
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2017-08-03
PublicationDateYYYYMMDD 2017-08-03
PublicationDate_xml – month: 08
  year: 2017
  text: 2017-08-03
  day: 03
PublicationDecade 2010
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle International journal of molecular sciences
PublicationTitleAlternate Int J Mol Sci
PublicationYear 2017
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Saka (ref_4) 2016; 19
Inoue (ref_55) 2005; 35
Naito (ref_22) 2006; 130
Nozaki (ref_67) 2002; 93
Tsugane (ref_62) 1992; 98
Tu (ref_42) 2008; 14
Leung (ref_97) 2004; 53
Tatematsu (ref_36) 1993; 84
ref_19
Chen (ref_102) 2016; 19
Ohno (ref_73) 2016; 35
ref_17
Uemura (ref_18) 2001; 345
Annibale (ref_88) 2000; 14
Draper (ref_30) 2017; 8
Dabos (ref_76) 2010; 17
Yanaoka (ref_103) 2009; 125
Huang (ref_15) 1998; 114
Yun (ref_81) 1995; 4
Sugiyama (ref_50) 1998; 58
Krakowka (ref_23) 1987; 55
Murakami (ref_93) 1997; 32
Shimizu (ref_52) 1999; 34
Thompson (ref_31) 2004; 72
Tatematsu (ref_35) 1992; 83
Parsonnet (ref_16) 1994; 330
Tajima (ref_61) 1985; 76
Asaka (ref_14) 1996; 1
Carrington (ref_41) 2001; 412
Watanabe (ref_48) 1998; 115
Reddy (ref_121) 1987; 47
Graham (ref_12) 1992; 116
Shimizu (ref_51) 1999; 20
Marone (ref_74) 2001; 13
Jukic (ref_60) 2017; 37
Warren (ref_5) 1983; 1
You (ref_95) 2006; 98
Paraschos (ref_78) 2007; 51
Nishino (ref_57) 2006; 36
Shimizu (ref_108) 2000; 60
Inoue (ref_69) 1998; 9
Jiang (ref_38) 2017; 8
Kiriyama (ref_86) 2016; 6
Joossens (ref_63) 1996; 25
Shibata (ref_70) 2000; 10
Kato (ref_66) 2006; 119
Erkan (ref_94) 2012; 208
Karita (ref_25) 1991; 86
Cao (ref_112) 2007; 98
Torre (ref_1) 2016; 25
Chiu (ref_120) 1997; 57
Oshima (ref_39) 2004; 23
Tatematsu (ref_65) 1975; 55
Backert (ref_20) 2005; 13
Parsonnet (ref_9) 1991; 325
Honda (ref_47) 1998; 58
Kono (ref_64) 1996; 7
Kitamura (ref_107) 2014; 19
Uemura (ref_98) 1997; 6
Naito (ref_111) 2002; 33
Ito (ref_91) 2002; 16
Asaka (ref_3) 2014; 90
Takasu (ref_37) 2008; 99
Tatematsu (ref_53) 2003; 94
Toyoda (ref_84) 2016; 21
Mizoshita (ref_54) 2006; 97
Yanaoka (ref_122) 2010; 126
Mera (ref_96) 2005; 54
Marshall (ref_6) 1984; 1
Kamangar (ref_82) 2007; 16
Wang (ref_44) 2000; 118
Kawakubo (ref_68) 2004; 305
Hwang (ref_80) 2015; 11
Karita (ref_26) 1994; 89
Okubo (ref_85) 2011; 46
Suerbaum (ref_32) 2007; 5
Sasazuki (ref_56) 2002; 101
Bae (ref_100) 2014; 109
Tatematsu (ref_49) 1998; 89
Lee (ref_29) 1997; 112
Hirayama (ref_45) 1996; 31
Forman (ref_11) 1991; 302
Magari (ref_119) 2005; 334
Hatakeyama (ref_21) 2011; 102
Cao (ref_113) 2008; 122
Tsukamoto (ref_2) 2013; 35
Schlemper (ref_104) 2000; 15
Bebb (ref_75) 2003; 52
Bae (ref_79) 2014; 38
Craanen (ref_8) 1992; 33
Ito (ref_106) 2005; 21
Zhang (ref_123) 2015; 36
Echizen (ref_115) 2016; 107
ref_114
Radin (ref_24) 1990; 58
Nozaki (ref_109) 2003; 94
Oshima (ref_40) 2006; 131
Marchetti (ref_27) 1995; 267
ref_33
Prescott (ref_117) 2000; 1470
Wang (ref_43) 1992; 65
Lee (ref_28) 1990; 99
Leung (ref_116) 2006; 18
Tsugane (ref_110) 2007; 10
Lee (ref_87) 2013; 62
Wong (ref_101) 2004; 291
Kodama (ref_90) 2012; 47
Nozaki (ref_46) 2002; 93
Nomura (ref_10) 1991; 325
Miwa (ref_83) 2002; 97
Loughlin (ref_77) 2003; 51
Yang (ref_72) 2016; 67
Toyokawa (ref_92) 2010; 25
ref_105
Futagami (ref_118) 2006; 74
Yang (ref_71) 1997; 105
Fukase (ref_99) 2008; 372
Tamer (ref_58) 2005; 23
Tian (ref_59) 2013; 80
Sugimura (ref_34) 1967; 216
Hu (ref_7) 1995; 36
Kuipers (ref_13) 1995; 345
Forbes (ref_89) 1996; 11
18059022 - Int J Cancer. 2008 Apr 1;122(7):1445-54
17372265 - Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):629-30
9398913 - Helicobacter. 1996 Mar;1(1):52-6
1558340 - Ann Intern Med. 1992 May 1;116(9):705-8
9331087 - Cancer Res. 1997 Oct 1;57(19):4267-73
1740271 - Gut. 1992 Jan;33(1):16-20
25781635 - PLoS One. 2015 Mar 17;10(3):e0120938
15740539 - Aliment Pharmacol Ther. 2005 Mar 1;21(5):559-66
11806621 - J Chemother. 2001 Dec;13(6):611-4
17505524 - Nat Rev Microbiol. 2007 Jun;5(6):441-52
22698649 - Gut. 2013 May;62(5):676-82
27338284 - Int J Food Sci Nutr. 2016 Nov;67(7):818-27
19711347 - Int J Cancer. 2010 Mar 15;126(6):1467-73
1429199 - Jpn J Cancer Res. 1992 Sep;83(9):915-8
12014714 - Am J Gastroenterol. 2002 May;97(5):1106-12
6134060 - Lancet. 1983 Jun 4;1(8336):1273-5
10616768 - J Gastroenterol. 1999;34 Suppl 11:61-6
12182744 - Aliment Pharmacol Ther. 2002 Aug;16(8):1449-56
15271928 - Infect Immun. 2004 Aug;72(8):4668-79
9605743 - Cancer Res. 1998 May 15;58(10):2067-9
1891021 - N Engl J Med. 1991 Oct 17;325(16):1132-6
22277792 - Pathol Res Pract. 2012 Feb 15;208(2):89-93
6145023 - Lancet. 1984 Jun 16;1(8390):1311-5
17030179 - Gastroenterology. 2006 Oct;131(4):1086-95
10223198 - Carcinogenesis. 1999 Apr;20(4):669-76
8098787 - Lancet. 1993 May 29;341(8857):1359-62
23111700 - Semin Immunopathol. 2013 Mar;35(2):177-90
24558304 - J Ginseng Res. 2014 Jan;38(1):8-15
16367919 - Cancer Sci. 2006 Jan;97(1):38-44
16009342 - Biochem Biophys Res Commun. 2005 Aug 26;334(2):606-12
6074981 - Nature. 1967 Dec 2;216(5118):943-4
9766647 - Cancer Res. 1998 Oct 1;58(19):4255-9
11100994 - J Gastroenterol Hepatol. 2000 Oct;15 Suppl:G49-57
23414681 - Med Hypotheses. 2013 May;80(5):672-4
25169671 - Proc Jpn Acad Ser B Phys Biol Sci. 2014;90(7):251-8
11059513 - J Epidemiol. 2000 Sep;10(5):310-6
17116667 - Antimicrob Agents Chemother. 2007 Feb;51(2):551-9
26140520 - Helicobacter. 2016 Apr;21(2):131-42
26449252 - Carcinogenesis. 2015 Dec;36(12):1572-9
9609753 - Gastroenterology. 1998 Jun;114(6):1169-79
3666963 - Infect Immun. 1987 Nov;55(11):2789-96
808633 - J Natl Cancer Inst. 1975 Jul;55(1):101-6
9578298 - Cancer Causes Control. 1998 Mar;9(2):209-16
20942897 - Cancer Sci. 2011 Jan;102(1):36-43
9085165 - J Gastroenterol. 1997 Apr;32(2):184-8
16099656 - Trends Microbiol. 2005 Oct;13(10):476-84
17284248 - Cancer Sci. 2007 Apr;98(4):478-83
25752268 - Gastric Cancer. 2016 Apr;19(2):524-30
15014433 - EMBO J. 2004 Apr 7;23 (7):1669-78
12708487 - Cancer Sci. 2003 Feb;94(2):135-41
10722929 - Biochim Biophys Acta. 2000 Mar 27;1470(2):M69-78
3652039 - Cancer Res. 1987 Oct 15;47(20):5340-6
18675689 - Lancet. 2008 Aug 2;372(9636):392-7
19610064 - Int J Cancer. 2009 Dec 1;125(11):2697-703
17577615 - Gastric Cancer. 2007;10(2):75-83
16849680 - J Natl Cancer Inst. 2006 Jul 19;98(14):974-83
9721161 - Gastroenterology. 1998 Sep;115(3):642-8
10611152 - Gastroenterology. 2000 Jan;118(1):36-47
12562704 - J Antimicrob Chemother. 2003 Feb;51(2):367-71
11985786 - Jpn J Cancer Res. 2002 Apr;93(4):374-81
24766284 - Helicobacter. 2014 Aug;19(4):289-95
10792127 - Aliment Pharmacol Ther. 2000 May;14(5):625-34
19817964 - J Gastroenterol Hepatol. 2010 Mar;25(3):544-7
27713138 - Oncotarget. 2017 Jan 10;8(2):3696-3710
11556297 - N Engl J Med. 2001 Sep 13;345(11):784-9
15473001 - Cell Biochem Funct. 2005 Jul-Aug;23(4):267-72
15310903 - Science. 2004 Aug 13;305(5686):1003-6
17341852 - Digestion. 2006;74(3-4):187-98
15306578 - Gut. 2004 Sep;53(9):1244-9
7886456 - Science. 1995 Mar 17;267(5204):1655-8
16646055 - Int J Cancer. 2006 Oct 1;119(7):1558-66
26667886 - Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):16-27
12888582 - J Antimicrob Chemother. 2003 Sep;52(3):522-3
10749114 - Cancer Res. 2000 Mar 15;60(6):1512-4
25807464 - PLoS One. 2015 Mar 25;10(3):e0121841
9098027 - Gastroenterology. 1997 Apr;112(4):1386-97
25333578 - Mol Med Rep. 2015 Jan;11(1):670-6
28223462 - MBio. 2017 Feb 21;8(1):null
8294216 - Jpn J Cancer Res. 1993 Dec;84(12):1258-64
19879118 - Phytomedicine. 2010 Mar;17 (3-4):296-9
12824915 - Cancer Sci. 2003 Mar;94(3):235-9
22138891 - J Gastroenterol. 2012 Apr;47(4):394-403
2210240 - Gastroenterology. 1990 Nov;99(5):1315-23
9255589 - Environ Health Perspect. 1997 Jun;105 Suppl 4:971-6
20967557 - J Gastroenterol. 2011 Feb;46(2):175-82
8840244 - J Gastroenterol Hepatol. 1996 Jul;11(7):670-3
15985559 - Gut. 2005 Nov;54(11):1536-40
9548434 - Jpn J Cancer Res. 1998 Feb;89(2):97-104
27079437 - Cancer Sci. 2016 Apr;107(4):391-7
16825903 - Eur J Gastroenterol Hepatol. 2006 Aug;18(8):867-71
7883217 - Gut. 1995 Feb;36(2):198-202
12237898 - Int J Cancer. 2002 Oct 20;101(6):560-6
24343545 - Am J Gastroenterol. 2014 Jan;109(1):60-7
25609452 - Gastric Cancer. 2016 Jan;19(1):166-75
11808612 - Nature. 2001 Jul 5;412(6842):99
2370111 - Infect Immun. 1990 Aug;58(8):2606-12
27035882 - Oncol Rep. 2016 Jun;35(6):3241-7
16618412 - Gastroenterology. 2006 Apr;130(4):1181-90
28011491 - Anticancer Res. 2017 Jan;37(1):197-202
1486851 - Environ Health Perspect. 1992 Nov;98:207-10
1891020 - N Engl J Med. 1991 Oct 17;325(16):1127-31
2059685 - BMJ. 1991 Jun 1;302(6788):1302-5
8671549 - Int J Epidemiol. 1996 Jun;25(3):494-504
7655337 - Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):401-8
14722144 - JAMA. 2004 Jan 14;291(2):187-94
8959513 - J Gastroenterol. 1996 Nov;31 Suppl 9:24-8
7791437 - Lancet. 1995 Jun 17;345(8964):1525-8
19018769 - Cancer Sci. 2008 Dec;99(12 ):2356-64
3930448 - Jpn J Cancer Res. 1985 Aug;76(8):705-16
8304305 - Am J Gastroenterol. 1994 Feb;89(2):208-13
15987784 - Jpn J Clin Oncol. 2005 Jul;35(7):404-11
9264278 - Cancer Epidemiol Biomarkers Prev. 1997 Aug;6(8):639-42
1951236 - Am J Gastroenterol. 1991 Nov;86(11):1596-603
12417037 - Jpn J Cancer Res. 2002 Oct;93(10):1083-9
18977329 - Cancer Cell. 2008 Nov 4;14(5):408-19
1341073 - Yale J Biol Med. 1992 Nov-Dec;65(6):705-13; discussion 737-40
8850434 - Cancer Causes Control. 1996 Jan;7(1):41-55
21573743 - Gastric Cancer. 2011 Jun;14(2):101-12
12126754 - Free Radic Biol Med. 2002 Aug 1;33(3):323-36
17210611 - Jpn J Clin Oncol. 2006 Dec;36(12 ):800-7
8145781 - N Engl J Med. 1994 May 5;330(18):1267-71
References_xml – volume: 115
  start-page: 642
  year: 1998
  ident: ref_48
  article-title: Helicobacter pylori infection induces gastric cancer in mongolian gerbils
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(98)70143-X
– volume: 122
  start-page: 1445
  year: 2008
  ident: ref_113
  article-title: 4-Vinyl-2,6-dimethoxyphenol (canolol) suppresses oxidative stress and gastric carcinogenesis in Helicobacter pylori-infected carcinogen-treated Mongolian gerbils
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.23245
– volume: 325
  start-page: 1127
  year: 1991
  ident: ref_9
  article-title: Helicobacter pylori infection and the risk of gastric carcinoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199110173251603
– ident: ref_33
  doi: 10.1371/journal.pone.0121841
– volume: 23
  start-page: 1669
  year: 2004
  ident: ref_39
  article-title: Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7600170
– volume: 25
  start-page: 544
  year: 2010
  ident: ref_92
  article-title: Eradication of Helicobacter pylori infection improved gastric mucosal atrophy and prevented progression of intestinal metaplasia, especially in the elderly population: A long-term prospective cohort study
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2009.05995.x
– volume: 325
  start-page: 1132
  year: 1991
  ident: ref_10
  article-title: Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199110173251604
– volume: 98
  start-page: 207
  year: 1992
  ident: ref_62
  article-title: Cross-sectional study with multiple measurements of biological markers for assessing stomach cancer risks at the population level
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.9298207
– volume: 13
  start-page: 611
  year: 2001
  ident: ref_74
  article-title: Bactericidal activity of pistacia lentiscus mastic gum against Helicobacter pylori
  publication-title: J. Chemother.
  doi: 10.1179/joc.2001.13.6.611
– volume: 116
  start-page: 705
  year: 1992
  ident: ref_12
  article-title: Effect of treatment of Helicobacter pylori infection on the long-term recurrence of gastric or duodenal ulcer. A randomized, controlled study
  publication-title: Ann. Intern. Med.
  doi: 10.7326/0003-4819-116-9-705
– volume: 17
  start-page: 296
  year: 2010
  ident: ref_76
  article-title: The effect of mastic gum on Helicobacter pylori: A randomized pilot study
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2009.09.010
– volume: 7
  start-page: 41
  year: 1996
  ident: ref_64
  article-title: Nutrition and stomach cancer
  publication-title: Cancer Causes Control
  doi: 10.1007/BF00115637
– volume: 35
  start-page: 3241
  year: 2016
  ident: ref_73
  article-title: Effect of green tea catechins on gastric mucosal dysplasia in insulin-gastrin mice
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2016.4717
– volume: 105
  start-page: 971
  year: 1997
  ident: ref_71
  article-title: Polyphenols as inhibitors of carcinogenesis
  publication-title: Environ. Health Perspect.
– volume: 10
  start-page: 75
  year: 2007
  ident: ref_110
  article-title: Diet and the risk of gastric cancer: Review of epidemiological evidence
  publication-title: Gastric Cancer
  doi: 10.1007/s10120-007-0420-0
– volume: 36
  start-page: 1572
  year: 2015
  ident: ref_123
  article-title: Helicobacter pylori, cyclooxygenase-2 and evolution of gastric lesions: Results from an intervention trial in China
  publication-title: Carcinogenesis
– volume: 86
  start-page: 1596
  year: 1991
  ident: ref_25
  article-title: New small animal model for human gastric Helicobacter pylori infection: Success in both nude and euthymic mice
  publication-title: Am. J. Gastroenterol.
– volume: 51
  start-page: 551
  year: 2007
  ident: ref_78
  article-title: In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00642-06
– volume: 11
  start-page: 670
  year: 1996
  ident: ref_89
  article-title: Long-term follow-up of gastric histology after Helicobacter pylori eradication
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.1996.tb00312.x
– volume: 37
  start-page: 197
  year: 2017
  ident: ref_60
  article-title: Gender difference in distribution of estrogen and androgen receptors in intestinal-type gastric cancer
  publication-title: Anticancer Res.
  doi: 10.21873/anticanres.11306
– volume: 36
  start-page: 800
  year: 2006
  ident: ref_57
  article-title: Tobacco smoking and gastric cancer risk: An evaluation based on a systematic review of epidemiologic evidence among the Japanese population
  publication-title: Jpn. J. Clin. Oncol.
  doi: 10.1093/jjco/hyl112
– volume: 131
  start-page: 1086
  year: 2006
  ident: ref_40
  article-title: Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.07.014
– volume: 34
  start-page: 61
  year: 1999
  ident: ref_52
  article-title: New animal model of glandular stomach carcinogenesis in Mongolian gerbils infected with Helicobacter pylori and treated with a chemical carcinogen
  publication-title: J. Gastroenterol.
– volume: 98
  start-page: 974
  year: 2006
  ident: ref_95
  article-title: Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/djj264
– volume: 19
  start-page: 524
  year: 2016
  ident: ref_4
  article-title: Endoscopic and histological features of gastric cancers after successful Helicobacter pylori eradication therapy
  publication-title: Gastric Cancer
  doi: 10.1007/s10120-015-0479-y
– volume: 31
  start-page: 24
  year: 1996
  ident: ref_45
  article-title: Establishment of gastric Helicobacter pylori infection in Mongolian gerbils
  publication-title: J. Gastroenterol.
  doi: 10.1007/BF02347631
– volume: 55
  start-page: 101
  year: 1975
  ident: ref_65
  article-title: Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/55.1.101
– volume: 10
  start-page: 310
  year: 2000
  ident: ref_70
  article-title: Green tea consumption and chronic atrophic gastritis: A cross-sectional study in a green tea production village
  publication-title: J. Epidemiol.
  doi: 10.2188/jea.10.310
– volume: 4
  start-page: 401
  year: 1995
  ident: ref_81
  article-title: Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs
  publication-title: Cancer Epidemiol. Biomarkers Prev.
– volume: 97
  start-page: 38
  year: 2006
  ident: ref_54
  article-title: Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2006.00135.x
– volume: 126
  start-page: 1467
  year: 2010
  ident: ref_122
  article-title: Preventive effects of etodolac, a selective cyclooxygenase-2 inhibitor, on cancer development in extensive metaplastic gastritis, a Helicobacter pylori-negative precancerous lesion
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.24862
– volume: 98
  start-page: 478
  year: 2007
  ident: ref_112
  article-title: Severity of gastritis determines glandular stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2007.00416.x
– volume: 102
  start-page: 36
  year: 2011
  ident: ref_21
  article-title: Anthropological and clinical implications for the structural diversity of the Helicobacter pylori CagA oncoprotein
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2010.01743.x
– volume: 35
  start-page: 177
  year: 2013
  ident: ref_2
  article-title: Helicobacter pylori infection and gastric carcinogenesis in rodent models
  publication-title: Semin. Immunopathol.
  doi: 10.1007/s00281-012-0357-1
– volume: 53
  start-page: 1244
  year: 2004
  ident: ref_97
  article-title: Factors predicting progression of gastric intestinal metaplasia: Results of a randomised trial on Helicobacter pylori eradication
  publication-title: Gut
  doi: 10.1136/gut.2003.034629
– volume: 112
  start-page: 1386
  year: 1997
  ident: ref_29
  article-title: A standardized mouse model of Helicobacter pylori infection: Introducing the Sydney strain
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(97)70155-0
– volume: 302
  start-page: 1302
  year: 1991
  ident: ref_11
  article-title: Association between infection with Helicobacter pylori and risk of gastric cancer: Evidence from a prospective investigation
  publication-title: BMJ
  doi: 10.1136/bmj.302.6788.1302
– volume: 118
  start-page: 36
  year: 2000
  ident: ref_44
  article-title: Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(00)70412-4
– volume: 54
  start-page: 1536
  year: 2005
  ident: ref_96
  article-title: Long term follow up of patients treated for Helicobacter pylori infection
  publication-title: Gut
  doi: 10.1136/gut.2005.072009
– volume: 125
  start-page: 2697
  year: 2009
  ident: ref_103
  article-title: Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.24591
– volume: 345
  start-page: 784
  year: 2001
  ident: ref_18
  article-title: Helicobacter pylori infection and the development of gastric cancer
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa001999
– volume: 60
  start-page: 1512
  year: 2000
  ident: ref_108
  article-title: Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils
  publication-title: Cancer Res.
– volume: 19
  start-page: 289
  year: 2014
  ident: ref_107
  article-title: Characteristic epithelium with low-grade atypia appears on the surface of gastric cancer after successful Helicobacter pylori eradication therapy
  publication-title: Helicobacter
  doi: 10.1111/hel.12132
– volume: 130
  start-page: 1181
  year: 2006
  ident: ref_22
  article-title: Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2005.12.038
– volume: 58
  start-page: 4255
  year: 1998
  ident: ref_47
  article-title: Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils
  publication-title: Cancer Res.
– ident: ref_105
  doi: 10.1007/s10120-011-0041-5
– volume: 267
  start-page: 1655
  year: 1995
  ident: ref_27
  article-title: Development of a mouse model of Helicobacter pylori infection that mimics human disease
  publication-title: Science
  doi: 10.1126/science.7886456
– volume: 1470
  start-page: M69
  year: 2000
  ident: ref_117
  article-title: Cyclooxygenase-2 and carcinogenesis
  publication-title: Biochim. Biophys. Acta
– volume: 32
  start-page: 184
  year: 1997
  ident: ref_93
  article-title: Helicobacter pylori infection accelerates human gastric mucosal cell proliferation
  publication-title: J. Gastroenterol.
  doi: 10.1007/BF02936365
– volume: 80
  start-page: 672
  year: 2013
  ident: ref_59
  article-title: Androgen receptor may be responsible for gender disparity in gastric cancer
  publication-title: Med. Hypotheses
  doi: 10.1016/j.mehy.2013.01.023
– volume: 1
  start-page: 52
  year: 1996
  ident: ref_14
  article-title: Atrophic changes of gastric mucosa are caused by Helicobacter pylori infection rather than aging: Studies in asymptomatic Japanese adults
  publication-title: Helicobacter
  doi: 10.1111/j.1523-5378.1996.tb00008.x
– volume: 46
  start-page: 175
  year: 2011
  ident: ref_85
  article-title: Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication
  publication-title: J. Gastroenterol.
  doi: 10.1007/s00535-010-0335-0
– volume: 8
  start-page: e02321
  year: 2017
  ident: ref_30
  article-title: Fallacy of the unique genome: Sequence diversity within single Helicobacter pylori strains
  publication-title: MBio
  doi: 10.1128/mBio.02321-16
– volume: 11
  start-page: 670
  year: 2015
  ident: ref_80
  article-title: An enzymatically fortified ginseng extract inhibits proliferation and induces apoptosis of KATO3 human gastric cancer cells via modulation of Bax, mTOR, PKB and IκBα
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2014.2704
– volume: 14
  start-page: 625
  year: 2000
  ident: ref_88
  article-title: Cure of Helicobacter pylori infection in atrophic body gastritis patients does not improve mucosal atrophy but reduces hypergastrinemia and its related effects on body ECL-cell hyperplasia
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1046/j.1365-2036.2000.00752.x
– volume: 93
  start-page: 374
  year: 2002
  ident: ref_46
  article-title: Reversibility of Heterotopic proliferative glands in glandular stomach of Helicobacter pylori-infected mongolian gerbils on eradication
  publication-title: Jpn. J. Cancer Res.
  doi: 10.1111/j.1349-7006.2002.tb01267.x
– volume: 208
  start-page: 89
  year: 2012
  ident: ref_94
  article-title: Evaluation of apoptosis along with BCL-2 and Ki-67 expression in patients with intestinal metaplasia
  publication-title: Pathol. Res. Pract.
  doi: 10.1016/j.prp.2011.12.002
– volume: 1
  start-page: 1311
  year: 1984
  ident: ref_6
  article-title: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration
  publication-title: Lancet
  doi: 10.1016/S0140-6736(84)91816-6
– ident: ref_19
– volume: 13
  start-page: 476
  year: 2005
  ident: ref_20
  article-title: Tyrosine-phosphorylated bacterial effector proteins: The enemies within
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2005.08.002
– volume: 305
  start-page: 1003
  year: 2004
  ident: ref_68
  article-title: Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection
  publication-title: Science
  doi: 10.1126/science.1099250
– volume: 23
  start-page: 267
  year: 2005
  ident: ref_58
  article-title: Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk
  publication-title: Cell Biochem. Funct.
  doi: 10.1002/cbf.1148
– volume: 55
  start-page: 2789
  year: 1987
  ident: ref_23
  article-title: Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet
  publication-title: Infect. Immun.
  doi: 10.1128/iai.55.11.2789-2796.1987
– volume: 216
  start-page: 943
  year: 1967
  ident: ref_34
  article-title: Tumour production in glandular stomach of rat by N-methyl-N′-nitro-N-nitrosoguanidine
  publication-title: Nature
  doi: 10.1038/216943a0
– volume: 14
  start-page: 408
  year: 2008
  ident: ref_42
  article-title: Overexpression of interleukin-1β induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2008.10.011
– volume: 97
  start-page: 1106
  year: 2002
  ident: ref_83
  article-title: H. pylori and gastric cancer: The Asian enigma
  publication-title: Am. J. Gastroenterol.
  doi: 10.1111/j.1572-0241.2002.05663.x
– volume: 8
  start-page: 3696
  year: 2017
  ident: ref_38
  article-title: Transgenic and gene knockout mice in gastric cancer research
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12467
– volume: 93
  start-page: 1083
  year: 2002
  ident: ref_67
  article-title: Synergistic Promoting effects of Helicobacter pylori infection and high-salt diet on gastric carcinogenesis in mongolian gerbils
  publication-title: Jpn. J. Cancer Res.
  doi: 10.1111/j.1349-7006.2002.tb01209.x
– volume: 21
  start-page: 559
  year: 2005
  ident: ref_106
  article-title: Morphological changes in human gastric tumours after eradication therapy of Helicobacter pylori in a short-term follow-up
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1111/j.1365-2036.2005.02360.x
– volume: 291
  start-page: 187
  year: 2004
  ident: ref_101
  article-title: Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial
  publication-title: Jama
  doi: 10.1001/jama.291.2.187
– volume: 114
  start-page: 1169
  year: 1998
  ident: ref_15
  article-title: Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(98)70422-6
– volume: 33
  start-page: 16
  year: 1992
  ident: ref_8
  article-title: Intestinal metaplasia and Helicobacter pylori: An endoscopic bioptic study of the gastric antrum
  publication-title: Gut
  doi: 10.1136/gut.33.1.16
– volume: 36
  start-page: 198
  year: 1995
  ident: ref_7
  article-title: Helicobacter pylori associated with a high prevalence of duodenal ulcer disease and a low prevalence of gastric cancer in a developing nation
  publication-title: Gut
  doi: 10.1136/gut.36.2.198
– volume: 33
  start-page: 323
  year: 2002
  ident: ref_111
  article-title: Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/S0891-5849(02)00868-7
– volume: 35
  start-page: 404
  year: 2005
  ident: ref_55
  article-title: Evaluation based on systematic review of epidemiological evidence among Japanese populations: Tobacco smoking and total cancer risk
  publication-title: Jpn. J. Clin. Oncol.
  doi: 10.1093/jjco/hyi114
– volume: 5
  start-page: 441
  year: 2007
  ident: ref_32
  article-title: Helicobacter pylori evolution and phenotypic diversification in a changing host
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro1658
– volume: 15
  start-page: G49
  year: 2000
  ident: ref_104
  article-title: Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: Proposal for a new classification system of gastrointestinal epithelial neoplasia
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1046/j.1440-1746.2000.02266.x
– volume: 89
  start-page: 97
  year: 1998
  ident: ref_49
  article-title: Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine in drinking water
  publication-title: Jpn. J. Cancer Res.
  doi: 10.1111/j.1349-7006.1998.tb00535.x
– volume: 89
  start-page: 208
  year: 1994
  ident: ref_26
  article-title: Establishment of a small animal model for human Helicobacter pylori infection using germ-free mouse
  publication-title: Am. J. Gastroenterol.
– volume: 74
  start-page: 187
  year: 2006
  ident: ref_118
  article-title: Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils
  publication-title: Digestion
  doi: 10.1159/000100503
– volume: 58
  start-page: 2067
  year: 1998
  ident: ref_50
  article-title: Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil
  publication-title: Cancer Res.
– volume: 47
  start-page: 5340
  year: 1987
  ident: ref_121
  article-title: Dose-related inhibition of colon carcinogenesis by dietary piroxicam, a nonsteroidal antiinflammatory drug, during different stages of rat colon tumor development
  publication-title: Cancer Res.
– volume: 16
  start-page: 1449
  year: 2002
  ident: ref_91
  article-title: Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: A 5-year prospective study of patients with atrophic gastritis
  publication-title: Aliment. Pharmacol. Ther.
  doi: 10.1046/j.1365-2036.2002.01311.x
– volume: 18
  start-page: 867
  year: 2006
  ident: ref_116
  article-title: Chemoprevention of gastric cancer
  publication-title: Eur. J. Gastroenterol. Hepatol.
  doi: 10.1097/00042737-200608000-00010
– ident: ref_17
  doi: 10.1016/0140-6736(93)90938-D
– volume: 83
  start-page: 915
  year: 1992
  ident: ref_35
  article-title: Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea
  publication-title: Jpn. J. Cancer Res.
  doi: 10.1111/j.1349-7006.1992.tb01999.x
– volume: 109
  start-page: 60
  year: 2014
  ident: ref_100
  article-title: Effect of Helicobacter pylori eradication on metachronous recurrence after endoscopic resection of gastric neoplasm
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2013.404
– volume: 65
  start-page: 705
  year: 1992
  ident: ref_43
  article-title: Function and regulation of gastrin in transgenic mice: A review
  publication-title: Yale J. Biol. Med.
– volume: 21
  start-page: 131
  year: 2016
  ident: ref_84
  article-title: Anti-inflammatory effects of capsaicin and piperine on Helicobacter pylori-induced chronic gastritis in mongolian gerbils
  publication-title: Helicobacter
  doi: 10.1111/hel.12243
– volume: 412
  start-page: 99
  year: 2001
  ident: ref_41
  article-title: The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer
  publication-title: Nature
  doi: 10.1038/35083631
– volume: 6
  start-page: 639
  year: 1997
  ident: ref_98
  article-title: Effect of Helicobacter pylori eradication on subsequent development of cancer after endoscopic resection of early gastric cancer
  publication-title: Cancer Epidemiol. Biomarkers Prev.
– volume: 16
  start-page: 629
  year: 2007
  ident: ref_82
  article-title: Ginseng intake and gastric cancer risk in the Shanghai Women’s Health Study cohort
  publication-title: Cancer Epidemiol. Biomarkers Prev.
  doi: 10.1158/1055-9965.EPI-06-1009
– volume: 9
  start-page: 209
  year: 1998
  ident: ref_69
  article-title: Tea and coffee consumption and the risk of digestive tract cancers: Data from a comparative case-referent study in Japan
  publication-title: Cancer Causes Control
  doi: 10.1023/A:1008890529261
– volume: 101
  start-page: 560
  year: 2002
  ident: ref_56
  article-title: Cigarette smoking, alcohol consumption and subsequent gastric cancer risk by subsite and histologic type
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.10649
– volume: 372
  start-page: 392
  year: 2008
  ident: ref_99
  article-title: Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: An open-label, randomised controlled trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(08)61159-9
– ident: ref_114
  doi: 10.1371/journal.pone.0120938
– volume: 1
  start-page: 1273
  year: 1983
  ident: ref_5
  article-title: Unidentified curved bacilli on gastric epithelium in active chronic gastritis
  publication-title: Lancet
– volume: 94
  start-page: 135
  year: 2003
  ident: ref_53
  article-title: Stem cells and gastric cancer-role of gastric and intestinal mixed intestinal metaplasia
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2003.tb01409.x
– volume: 334
  start-page: 606
  year: 2005
  ident: ref_119
  article-title: Inhibitory effect of etodolac, a selective cyclooxygenase-2 inhibitor, on stomach carcinogenesis in Helicobacter pylori-infected Mongolian gerbils
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2005.06.132
– volume: 107
  start-page: 391
  year: 2016
  ident: ref_115
  article-title: Inflammation in gastric cancer: Interplay of the COX-2/prostaglandin E2 and Toll-like receptor/MyD88 pathways
  publication-title: Cancer Sci.
  doi: 10.1111/cas.12901
– volume: 25
  start-page: 494
  year: 1996
  ident: ref_63
  article-title: Dietary salt, nitrate and stomach cancer mortality in 24 countries
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/25.3.494
– volume: 47
  start-page: 394
  year: 2012
  ident: ref_90
  article-title: Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradication
  publication-title: J. Gastroenterol.
  doi: 10.1007/s00535-011-0504-9
– volume: 19
  start-page: 166
  year: 2016
  ident: ref_102
  article-title: Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: Evidence from a meta-analysis
  publication-title: Gastric Cancer
  doi: 10.1007/s10120-015-0462-7
– volume: 84
  start-page: 1258
  year: 1993
  ident: ref_36
  article-title: Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water
  publication-title: Jpn. J. Cancer Res.
  doi: 10.1111/j.1349-7006.1993.tb02831.x
– volume: 94
  start-page: 235
  year: 2003
  ident: ref_109
  article-title: Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2003.tb01426.x
– volume: 51
  start-page: 367
  year: 2003
  ident: ref_77
  article-title: Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkg057
– volume: 20
  start-page: 669
  year: 1999
  ident: ref_51
  article-title: Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/20.4.669
– volume: 72
  start-page: 4668
  year: 2004
  ident: ref_31
  article-title: Chronic Helicobacter pylori infection with Sydney strain 1 and a newly identified mouse-adapted strain (Sydney strain 2000) in C57BL/6 and BALB/c mice
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.72.8.4668-4679.2004
– volume: 99
  start-page: 1315
  year: 1990
  ident: ref_28
  article-title: A small animal model of human Helicobacter pylori active chronic gastritis
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(90)91156-Z
– volume: 52
  start-page: 522
  year: 2003
  ident: ref_75
  article-title: Mastic gum has no effect on Helicobacter pylori load in vivo
  publication-title: J. Antimicrob. Chemother.
  doi: 10.1093/jac/dkg366
– volume: 119
  start-page: 1558
  year: 2006
  ident: ref_66
  article-title: High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.21810
– volume: 76
  start-page: 705
  year: 1985
  ident: ref_61
  article-title: Dietary habits and gastro-intestinal cancers: A comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan
  publication-title: Jpn. J. Cancer Res.
– volume: 345
  start-page: 1525
  year: 1995
  ident: ref_13
  article-title: Long-term sequelae of Helicobacter pylori gastritis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(95)91084-0
– volume: 58
  start-page: 2606
  year: 1990
  ident: ref_24
  article-title: Helicobacter pylori gastric infection in gnotobiotic beagle dogs
  publication-title: Infect. Immun.
  doi: 10.1128/iai.58.8.2606-2612.1990
– volume: 67
  start-page: 818
  year: 2016
  ident: ref_72
  article-title: Inhibition of green tea polyphenol EGCG((−)-epigallocatechin-3-gallate) on the proliferation of gastric cancer cells by suppressing canonical Wnt/β-catenin signalling pathway
  publication-title: Int. J. Food Sci. Nutr.
  doi: 10.1080/09637486.2016.1198892
– volume: 99
  start-page: 2356
  year: 2008
  ident: ref_37
  article-title: Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and β-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice
  publication-title: Cancer Sci.
  doi: 10.1111/j.1349-7006.2008.00983.x
– volume: 38
  start-page: 8
  year: 2014
  ident: ref_79
  article-title: Protective effect of korean red ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils
  publication-title: J. Ginseng Res.
  doi: 10.1016/j.jgr.2013.11.005
– volume: 57
  start-page: 4267
  year: 1997
  ident: ref_120
  article-title: Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis
  publication-title: Cancer Res.
– volume: 25
  start-page: 16
  year: 2016
  ident: ref_1
  article-title: Global Cancer incidence and mortality rates and trends—An update
  publication-title: Cancer Epidemiol. Biomarkers Prev.
  doi: 10.1158/1055-9965.EPI-15-0578
– volume: 6
  start-page: 93
  year: 2016
  ident: ref_86
  article-title: Gastric-and-intestinal mixed intestinal metaplasia is irreversible point with eradication of Helicobacter pylori
  publication-title: Open J. Pathol.
  doi: 10.4236/ojpathology.2016.62012
– volume: 90
  start-page: 251
  year: 2014
  ident: ref_3
  article-title: Strategies for eliminating death from gastric cancer in Japan
  publication-title: Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
  doi: 10.2183/pjab.90.251
– volume: 62
  start-page: 676
  year: 2013
  ident: ref_87
  article-title: The benefit of mass eradication of Helicobacter pylori infection: A community-based study of gastric cancer prevention
  publication-title: Gut
  doi: 10.1136/gutjnl-2012-302240
– volume: 330
  start-page: 1267
  year: 1994
  ident: ref_16
  article-title: Helicobacter pylori infection and gastric lymphoma
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199405053301803
– reference: 8145781 - N Engl J Med. 1994 May 5;330(18):1267-71
– reference: 26140520 - Helicobacter. 2016 Apr;21(2):131-42
– reference: 25752268 - Gastric Cancer. 2016 Apr;19(2):524-30
– reference: 17505524 - Nat Rev Microbiol. 2007 Jun;5(6):441-52
– reference: 1891020 - N Engl J Med. 1991 Oct 17;325(16):1127-31
– reference: 18977329 - Cancer Cell. 2008 Nov 4;14(5):408-19
– reference: 15310903 - Science. 2004 Aug 13;305(5686):1003-6
– reference: 9264278 - Cancer Epidemiol Biomarkers Prev. 1997 Aug;6(8):639-42
– reference: 6134060 - Lancet. 1983 Jun 4;1(8336):1273-5
– reference: 7655337 - Cancer Epidemiol Biomarkers Prev. 1995 Jun;4(4):401-8
– reference: 24343545 - Am J Gastroenterol. 2014 Jan;109(1):60-7
– reference: 20942897 - Cancer Sci. 2011 Jan;102(1):36-43
– reference: 25333578 - Mol Med Rep. 2015 Jan;11(1):670-6
– reference: 25169671 - Proc Jpn Acad Ser B Phys Biol Sci. 2014;90(7):251-8
– reference: 10616768 - J Gastroenterol. 1999;34 Suppl 11:61-6
– reference: 24766284 - Helicobacter. 2014 Aug;19(4):289-95
– reference: 3930448 - Jpn J Cancer Res. 1985 Aug;76(8):705-16
– reference: 28223462 - MBio. 2017 Feb 21;8(1):null
– reference: 9721161 - Gastroenterology. 1998 Sep;115(3):642-8
– reference: 9605743 - Cancer Res. 1998 May 15;58(10):2067-9
– reference: 8840244 - J Gastroenterol Hepatol. 1996 Jul;11(7):670-3
– reference: 15987784 - Jpn J Clin Oncol. 2005 Jul;35(7):404-11
– reference: 1341073 - Yale J Biol Med. 1992 Nov-Dec;65(6):705-13; discussion 737-40
– reference: 22277792 - Pathol Res Pract. 2012 Feb 15;208(2):89-93
– reference: 11059513 - J Epidemiol. 2000 Sep;10(5):310-6
– reference: 17030179 - Gastroenterology. 2006 Oct;131(4):1086-95
– reference: 19711347 - Int J Cancer. 2010 Mar 15;126(6):1467-73
– reference: 9085165 - J Gastroenterol. 1997 Apr;32(2):184-8
– reference: 1486851 - Environ Health Perspect. 1992 Nov;98:207-10
– reference: 17341852 - Digestion. 2006;74(3-4):187-98
– reference: 16009342 - Biochem Biophys Res Commun. 2005 Aug 26;334(2):606-12
– reference: 15740539 - Aliment Pharmacol Ther. 2005 Mar 1;21(5):559-66
– reference: 12417037 - Jpn J Cancer Res. 2002 Oct;93(10):1083-9
– reference: 16849680 - J Natl Cancer Inst. 2006 Jul 19;98(14):974-83
– reference: 8294216 - Jpn J Cancer Res. 1993 Dec;84(12):1258-64
– reference: 15014433 - EMBO J. 2004 Apr 7;23 (7):1669-78
– reference: 15985559 - Gut. 2005 Nov;54(11):1536-40
– reference: 7791437 - Lancet. 1995 Jun 17;345(8964):1525-8
– reference: 15306578 - Gut. 2004 Sep;53(9):1244-9
– reference: 17116667 - Antimicrob Agents Chemother. 2007 Feb;51(2):551-9
– reference: 27035882 - Oncol Rep. 2016 Jun;35(6):3241-7
– reference: 12014714 - Am J Gastroenterol. 2002 May;97(5):1106-12
– reference: 6145023 - Lancet. 1984 Jun 16;1(8390):1311-5
– reference: 12708487 - Cancer Sci. 2003 Feb;94(2):135-41
– reference: 19610064 - Int J Cancer. 2009 Dec 1;125(11):2697-703
– reference: 1558340 - Ann Intern Med. 1992 May 1;116(9):705-8
– reference: 22698649 - Gut. 2013 May;62(5):676-82
– reference: 6074981 - Nature. 1967 Dec 2;216(5118):943-4
– reference: 2210240 - Gastroenterology. 1990 Nov;99(5):1315-23
– reference: 9766647 - Cancer Res. 1998 Oct 1;58(19):4255-9
– reference: 26667886 - Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):16-27
– reference: 16618412 - Gastroenterology. 2006 Apr;130(4):1181-90
– reference: 19817964 - J Gastroenterol Hepatol. 2010 Mar;25(3):544-7
– reference: 9098027 - Gastroenterology. 1997 Apr;112(4):1386-97
– reference: 9578298 - Cancer Causes Control. 1998 Mar;9(2):209-16
– reference: 8959513 - J Gastroenterol. 1996 Nov;31 Suppl 9:24-8
– reference: 16646055 - Int J Cancer. 2006 Oct 1;119(7):1558-66
– reference: 17210611 - Jpn J Clin Oncol. 2006 Dec;36(12 ):800-7
– reference: 17284248 - Cancer Sci. 2007 Apr;98(4):478-83
– reference: 10722929 - Biochim Biophys Acta. 2000 Mar 27;1470(2):M69-78
– reference: 1740271 - Gut. 1992 Jan;33(1):16-20
– reference: 1429199 - Jpn J Cancer Res. 1992 Sep;83(9):915-8
– reference: 25609452 - Gastric Cancer. 2016 Jan;19(1):166-75
– reference: 18675689 - Lancet. 2008 Aug 2;372(9636):392-7
– reference: 11808612 - Nature. 2001 Jul 5;412(6842):99
– reference: 9609753 - Gastroenterology. 1998 Jun;114(6):1169-79
– reference: 12888582 - J Antimicrob Chemother. 2003 Sep;52(3):522-3
– reference: 28011491 - Anticancer Res. 2017 Jan;37(1):197-202
– reference: 11100994 - J Gastroenterol Hepatol. 2000 Oct;15 Suppl:G49-57
– reference: 18059022 - Int J Cancer. 2008 Apr 1;122(7):1445-54
– reference: 3652039 - Cancer Res. 1987 Oct 15;47(20):5340-6
– reference: 15473001 - Cell Biochem Funct. 2005 Jul-Aug;23(4):267-72
– reference: 16099656 - Trends Microbiol. 2005 Oct;13(10):476-84
– reference: 25807464 - PLoS One. 2015 Mar 25;10(3):e0121841
– reference: 12562704 - J Antimicrob Chemother. 2003 Feb;51(2):367-71
– reference: 3666963 - Infect Immun. 1987 Nov;55(11):2789-96
– reference: 25781635 - PLoS One. 2015 Mar 17;10(3):e0120938
– reference: 8304305 - Am J Gastroenterol. 1994 Feb;89(2):208-13
– reference: 11806621 - J Chemother. 2001 Dec;13(6):611-4
– reference: 12182744 - Aliment Pharmacol Ther. 2002 Aug;16(8):1449-56
– reference: 23414681 - Med Hypotheses. 2013 May;80(5):672-4
– reference: 10611152 - Gastroenterology. 2000 Jan;118(1):36-47
– reference: 24558304 - J Ginseng Res. 2014 Jan;38(1):8-15
– reference: 16367919 - Cancer Sci. 2006 Jan;97(1):38-44
– reference: 808633 - J Natl Cancer Inst. 1975 Jul;55(1):101-6
– reference: 27338284 - Int J Food Sci Nutr. 2016 Nov;67(7):818-27
– reference: 19018769 - Cancer Sci. 2008 Dec;99(12 ):2356-64
– reference: 20967557 - J Gastroenterol. 2011 Feb;46(2):175-82
– reference: 2059685 - BMJ. 1991 Jun 1;302(6788):1302-5
– reference: 12237898 - Int J Cancer. 2002 Oct 20;101(6):560-6
– reference: 8098787 - Lancet. 1993 May 29;341(8857):1359-62
– reference: 17372265 - Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):629-30
– reference: 27713138 - Oncotarget. 2017 Jan 10;8(2):3696-3710
– reference: 2370111 - Infect Immun. 1990 Aug;58(8):2606-12
– reference: 17577615 - Gastric Cancer. 2007;10(2):75-83
– reference: 11556297 - N Engl J Med. 2001 Sep 13;345(11):784-9
– reference: 7886456 - Science. 1995 Mar 17;267(5204):1655-8
– reference: 8671549 - Int J Epidemiol. 1996 Jun;25(3):494-504
– reference: 23111700 - Semin Immunopathol. 2013 Mar;35(2):177-90
– reference: 15271928 - Infect Immun. 2004 Aug;72(8):4668-79
– reference: 1891021 - N Engl J Med. 1991 Oct 17;325(16):1132-6
– reference: 9548434 - Jpn J Cancer Res. 1998 Feb;89(2):97-104
– reference: 8850434 - Cancer Causes Control. 1996 Jan;7(1):41-55
– reference: 22138891 - J Gastroenterol. 2012 Apr;47(4):394-403
– reference: 19879118 - Phytomedicine. 2010 Mar;17 (3-4):296-9
– reference: 10792127 - Aliment Pharmacol Ther. 2000 May;14(5):625-34
– reference: 26449252 - Carcinogenesis. 2015 Dec;36(12):1572-9
– reference: 9255589 - Environ Health Perspect. 1997 Jun;105 Suppl 4:971-6
– reference: 10749114 - Cancer Res. 2000 Mar 15;60(6):1512-4
– reference: 9398913 - Helicobacter. 1996 Mar;1(1):52-6
– reference: 21573743 - Gastric Cancer. 2011 Jun;14(2):101-12
– reference: 12824915 - Cancer Sci. 2003 Mar;94(3):235-9
– reference: 1951236 - Am J Gastroenterol. 1991 Nov;86(11):1596-603
– reference: 7883217 - Gut. 1995 Feb;36(2):198-202
– reference: 10223198 - Carcinogenesis. 1999 Apr;20(4):669-76
– reference: 14722144 - JAMA. 2004 Jan 14;291(2):187-94
– reference: 11985786 - Jpn J Cancer Res. 2002 Apr;93(4):374-81
– reference: 27079437 - Cancer Sci. 2016 Apr;107(4):391-7
– reference: 9331087 - Cancer Res. 1997 Oct 1;57(19):4267-73
– reference: 12126754 - Free Radic Biol Med. 2002 Aug 1;33(3):323-36
– reference: 16825903 - Eur J Gastroenterol Hepatol. 2006 Aug;18(8):867-71
SSID ssj0023259
Score 2.4219992
SecondaryResourceType review_article
Snippet Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the...
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium is known to colonize the human stomach and induce...
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the...
SourceID pubmedcentral
proquest
pubmed
crossref
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1699
SubjectTerms Animals
Bacteria
Gastric cancer
Helicobacter Infections - drug therapy
Helicobacter Infections - metabolism
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori
Humans
Public health
Review
Stomach Neoplasms - metabolism
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
Stomach Neoplasms - prevention & control
SummonAdditionalLinks – databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LaxRBEC7MihAIEtdHxkRpQU_SbE9Pz8tLkCW7wRDxYGBvQz_Jis7E3c3Bf2_VzOy4iei5i3l0ddVX1V1dH8BbGYxOCuG5Kl3gCg2IF0FqTp1BUh8Q8DO6KHz5OTu_Up8W6aLfcFv3ZZVbn9g6atdY2iOfYKCBUIpgU57e_OTEGkWnqz2Fxh48jPGpVNJVzOZDwpXIliwtRgziWVpmXeF7gmn-ZPntxzpuWSfarq87kPRXnHm_XHIHf2aH8LgPHNnHTtNP4IGvx_Coo5L8NYaDbv-NddeKnsLFtjdTU7MmsLkmfg7LpqTk1Qd2ttKu362jYQQfXBGm7dzMvlAOv2S6dqy73_IMrmZnX6fnvCdO4FblxYbLwoRMS2OdEM6H2CiZax8CGltp8fcxJrIBkdxnwSY2VrZwWovgZS4yK7VJnsOobmp_BEwrVRqHQUicOYX2bvKUDneF0OglSyUieL-du8r2XcWJ3OJ7hdkFzXS1O9MRvBukb7puGv-QO9mqoeptal39WQERvBmG0RroiEPXvrklGZliBCZFGsGLTmvDizA3zPGbiwjyO_ocBKjT9t2RennddtxO0a-Jonz5_886hn1JoE8FJckJjDarW_8KQ5aNed2uy9-o6OtN
  priority: 102
  providerName: ProQuest
Title Prevention of Gastric Cancer: Eradication of Helicobacter Pylori and Beyond
URI https://www.ncbi.nlm.nih.gov/pubmed/28771198
https://www.proquest.com/docview/1939935219
https://www.proquest.com/docview/1925893205
https://pubmed.ncbi.nlm.nih.gov/PMC5578089
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dSxwxEB_8QOiLWLX1qh4p6JOszeWym11BpMqdUlFEPLi3JckmeMXu2fOE-t93Zr_w_ABf9mWybHYmk_lNPuYHsCO80d2Yu0AmmQ8kOlAQe6EDqgwSOo8BP6KLwheX0dlA_hqGwzmo2UYrBT68mdoRn9Rgcrf_7-_TETr8IWWcmLL_GP3-89ApGCSSZB4WMSYp4jK4kM1-AsKGgjaNFjwCmqDLI_Cv3p4NTq8Q58uDk88iUX8FlisIyX6WNv8Mcy5fhaWSVPJpDc7rqkzjnI09O9XEzGHZCZl3csB6E51V63QkxrCDY8EUNZvZFWXvI6bzjJU3W9Zh0O_dnJwFFWVCYKWKp4GIjY-0MDbjPHO-Y6RQ2nmPbpZY_F1EQ9ZjDHeRt13bkTbOtObeCcUjK7TpfoGFfJy7DWBaysRkCD86USbR040KaVuXc43zYyJ5C_ZqXaW2qidOtBZ3KeYVpNn0uWZbsNu0vi_raLzTbqtWe1oPhhRBJsIoBBoo_t6I0Q9oc0PnbvxIbUSI2EvwsAVfSys1H8KsUGGf4xaoGfs1DajG9qwkH90WtbZDnNF4nHz7YPc34ZOguE9nSrpbsDCdPLptRC1T04Z5NVT4jPunbVg87l1eXbcpjoTtYqj-BznP7_8
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1da9RAcKgVURDR-hWtuoJ9kqWbzeZLEJHa69Vriw8t9C3dbHbxSk3q3RXpn_I3OpNN4lXRtz7vkA3zPbPzAfBGulJHmbBc5ZXjCgWIZ05qTpNBYuvQ4CfUKLx_kIyP1Ofj-HgFfva9MFRW2evEVlFXjaEc-SY6GmhK0djkH86_c9oaRa-r_QoNzxYTe_kDQ7b5-91PSN8NKUfbh1tj3m0V4Eal2YLLrHSJlqWphKisC0slU22dQ07MTRThNdI4NHM2cSYyoTJZpbVwVqYiMVKXEX73BtxUCErBXjbaGQK8SLbL2UK0eTyJ88QX2iOg2JyefpuH7ZaLdsrskgn8y6_9szxzyd6N7sO9zlFlHz1nPYAVW6_BLb-68nIN7vp8H_NtTA9h0s-CamrWOLajaR-IYVvEVLN3bHumqy47SMdo7JADy3ZSNPtCOYMp03XFfD_NIzi6FpQ-htW6qe1TYFqpvKzQ6QmTSqF-KdOYHpOF0KiVcyUCeNvjrjDdFHNapnFWYDRDmC6WMR3AxgB97qd3_ANuvSdD0cnwvPjNcQG8Ho5R-uhJRde2uSAYGaPHJ0UcwBNPteEijEVT_OcsgPQKPQcAmux99aSefm0nfMeoR0WWP_v_b72C2-PD_b1ib_dg8hzuSHI4qJglWofVxezCvkB3aVG-bHmUwcl1C8UvL8UqNg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1raxQxcKhXFEFE62u1agT7SZbLZrMvQUTbO1tPj0Ms9NuaZBN6RXfr3RXpX_PXObMvr4p-6-cMSZjMO_MAeC6cVmHKrS-zwvkSGchPnVA-dQaJrEOFH1Oh8MdpvH8o3x9FRxvws6uFobTKTibWgrqoDMXIh2hooCpFZZMNXZsWMdsbvz797tMEKfpp7cZpNCQysec_0H1bvjrYw7feEWI8-ry777cTBnwjk3Tli1S7WAltCs4L6wItRaKsc0iVmQlDPFIYhyrPxs6EJpAmLZTizoqEx0YoHeK-V2AzIa9oAJtvR9PZp97dC0U9qi1ADejHURY3afe4Kx_OT74tg3rmRd1zdk0h_mXl_pmsuab9xrfgZmu2sjcNnd2GDVtuwdVmkOX5Ftxoon-sKWq6A5OuM1RVssqxd4qmgxi2SyS2eMlGC1W0sUJaRtWH9KjrvtFsRhGEOVNlwZrqmrtweClIvQeDsirtA2BKykwXaAIFcSFR2ugkoq9lzhXK6ExyD150uMtN29OcRmt8zdG3IUzn65j2YKeHPm16efwDbrt7hrzl6GX-m_48eNYvIy_SB4sqbXVGMCJC-0_wyIP7zav1B6FnmuCdUw-SC-_ZA1Cf74sr5fy47vcdoVTlafbw_9d6CteQIfIPB9PJI7guyPqgzJZwGwarxZl9jLbTSj9piZTBl8vmi1_TcS_I
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prevention+of+Gastric+Cancer%3A+Eradication+of+Helicobacter+Pylori+and+Beyond&rft.jtitle=International+journal+of+molecular+sciences&rft.au=Tsukamoto%2C+Tetsuya&rft.au=Nakagawa%2C+Mitsuru&rft.au=Kiriyama%2C+Yuka&rft.au=Toyoda%2C+Takeshi&rft.date=2017-08-03&rft.issn=1422-0067&rft.eissn=1422-0067&rft.volume=18&rft.issue=8&rft.spage=1699&rft_id=info:doi/10.3390%2Fijms18081699&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_ijms18081699
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1422-0067&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1422-0067&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1422-0067&client=summon