Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine Model

• Published in: International journal of molecular sciences Vol. 20; no. 17; p. 4275
• Main Authors: Valadez-Bustos, Nancy, Escamilla-Silva, Eleazar M, García-Vázquez, Francisco J, Gallegos-Corona, Marco A, Amaya-Llano, Silvia L, Ramos-Gómez, Minerva
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.08.2019; MDPI
• Subjects: Administration, Oral; Animal models; Animals; Anticarcinogenic Agents - administration & dosage; Anticarcinogenic Agents - therapeutic use; Apoptosis; Azoxymethane; B. longum microencapsulated; Bacteria; Bifidobacterium longum - physiology; Bile acids; Cancer; Carbohydrates; Carcinogenesis; Carcinogens; Cell cycle; Cell differentiation; Cell growth; Cell proliferation; Colon; Colonization; Colorectal cancer; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Dextran; Dextran sulfate; Disease Models, Animal; Drying; Epithelial cells; Fatalities; Feces; Fermentation; gastrointestinal bacterial distribution; Gastrointestinal system; Gastrointestinal tract; IGF-1/IGF-1R/IGFBPs system; Insulin; Insulin-Like Growth Factor Binding Protein 3 - analysis; Insulin-like growth factor I; Insulin-Like Growth Factor I - analysis; Insulin-like growth factor-binding protein 3; Intestinal microflora; Intestine; Lycopene; Lycopene - administration & dosage; Lycopene - therapeutic use; Male; Mice; Mice, Inbred ICR; Mucus; Prebiotics; Probiotics; Probiotics - administration & dosage; Probiotics - therapeutic use; Receptor, IGF Type 1 - analysis; Spray drying; colorectal cancer; lycopene; gastrointestinal bacterial distribution; B. longum microencapsulated; IGF-1/IGF-1R/IGFBPs system

The Insulin-like growth factor-I/Insulin-like growth factor-I receptor (IGF-1/IGF-1R) system is a major determinant in colorectal cancer (CRC) pathogenesis. Probiotics ( , BF) and lycopene (LYC) have been individually researched for their beneficial effects in the prevention of CRC. However, the eff...