Mechanical and dynamic characteristics of encapsulated microbubbles coupled by magnetic nanoparticles as multifunctional imaging and drug delivery agents

• Published in: Physics in medicine & biology Vol. 59; no. 22; pp. 6729 - 6747
• Main Authors: Guo, Gepu, Lu, Lu, Yin, Leilei, Tu, Juan, Guo, Xiasheng, Wu, Junru, Xu, Di, Zhang, Dong
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 21.11.2014
• Subjects: Acoustics; Albumins - chemistry; atomic force microscopy; Cell Survival; Contrast Media - chemistry; Drug Delivery Systems; Enzyme-Linked Immunosorbent Assay; Ferric Compounds - chemistry; Fluorocarbons - chemistry; gene/drug delivery; HEK293 Cells; Humans; inertial cavitation; magnetic nanoparticles; Magnetic Resonance Imaging; Magnetite Nanoparticles - chemistry; Microbubbles; Microscopy, Atomic Force; Microscopy, Electron, Scanning; multifunctional contrast agent microbubbles; Multimodal Imaging - methods; Nanotechnology - methods; Phantoms, Imaging; Ultrasonics - methods; ultrasound imaging; Vascular Endothelial Growth Factor A - metabolism

Development of magnetic encapsulated microbubble agents that can integrate multiple diagnostic and therapeutic functions is a key focus in both biomedical engineering and nanotechnology and one which will have far-reaching impact on medical diagnosis and therapies. However, properly designing multif...