Regulation of AQP4 in the Central Nervous System

• Published in: International journal of molecular sciences Vol. 21; no. 5; p. 1603
• Main Authors: Vandebroek, Arno, Yasui, Masato
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.02.2020; MDPI
• Subjects: Acetazolamide; Animals; Aquaporin 4 - genetics; Aquaporin 4 - metabolism; Brain cancer; Cell adhesion & migration; Central Nervous System - metabolism; Central Nervous System Diseases - metabolism; Edema; Gene expression; Homeostasis; Humans; Ions - metabolism; Ischemia; Kinases; Localization; Metals - metabolism; MicroRNAs; Nervous system; Neurological disorders; Niacinamide - analogs & derivatives; Permeability; Phosphorylation; Potassium - metabolism; Proteins; Proteolipids; Review; Roles; Thiadiazoles; Water - metabolism; oocyte; aquaporin-4; water channel; acetazolamide; microRNA; metal ion; phosphorylation; proteoliposome; TGN-020; small molecule inhibitor

Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in CNS water and potassium homeostasis. Changes in AQP4 activity and expression have been implicated in several CNS disorder...