Biodegradable charged polyester-based vectors (BCPVs) as an efficient non-viral transfection nanoagent for gene knockdown of the BCR-ABL hybrid oncogene in a human chronic myeloid leukemia cell line

• Published in: Nanoscale Vol. 8; no. 17; pp. 945 - 9416
• Main Authors: Yang, Chengbin, Panwar, Nishtha, Wang, Yucheng, Zhang, Butian, Liu, Maixian, Toh, Huiting, Yoon, Ho Sup, Tjin, Swee Chuan, Chong, Peter Han Joo, Law, Wing-Cheung, Chen, Chih-Kuang, Yong, Ken-Tye
• Format: Journal Article
• Language: English
• Published: England 01.01.2016
• Subjects: Biodegradability; Charging; Chromosomes; Leukemias; Mathematical analysis; Nanostructure; Ribonucleic acids; Vectors (mathematics)

First-line therapy of chronic myelogenous leukemia (CML) has always involved the use of BCR-ABL tyrosine-kinase inhibitors which is associated with an abnormal chromosome called Philadelphia chromosome. Although the overall survival rate has been improved by the current therapeutic regime, the prese...