SIRT2 Inhibition Results in Meiotic Arrest, Mitochondrial Dysfunction, and Disturbance of Redox Homeostasis during Bovine Oocyte Maturation

• Published in: International journal of molecular sciences Vol. 20; no. 6; p. 1365
• Main Authors: Xu, Dejun, Wu, Lin, Jiang, Xiaohan, Yang, Li, Cheng, Jianyong, Chen, Huali, Hua, Rongmao, Geng, Guoxia, Yang, Lulu, Li, Qingwang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.03.2019; MDPI
• Subjects: Chromosomes; Defects; Metabolism; Mitochondria; Quality; Quantitative analysis; acetylation; meiosis; oocyte maturation; mitochondria; SIRT2

SIRT2, a member of the sirtuin family, has been recently shown to exert important effects on mitosis and/or metabolism. However, its roles in oocyte maturation have not been fully clarified. In this study, SIRT2, located in the cytoplasm and nucleus, was found in abundance in the meiotic stage, and...