Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis

• Published in: International journal of molecular sciences Vol. 20; no. 2; p. 360
• Main Authors: Pan, Xi-Chun, Liu, Ya, Cen, Yan-Yan, Xiong, Ya-Lan, Li, Jing-Mei, Ding, Yuan-Yuan, Tong, Yang-Fei, Liu, Tao, Chen, Xiao-Hong, Zhang, Hai-Gang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.01.2019; MDPI
• Subjects: Apoptosis; Collagen; Fibroblasts; Influence; Kinases; Morphology; Pathogens; Proteins; triptolide; cardiac fibrosis; apoptosis-associated speck-like protein containing a CARD; inflammasome; NOD-like receptor protein 3

In a previous paper, we reported that triptolide (TP), a commonly used immunomodulator, could attenuate cardiac hypertrophy. This present study aimed to further explore the inhibition of cardiac fibrosis by TP and the possible mechanism from the perspective of the NOD-like receptor protein 3 (NLRP3)...