Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 31; no. 7; pp. 1574 - 1582
• Main Authors: JIANWEN LIU, LEWOHL, Joanne M, HARRIS, R. Adron, LYER, Vishwanath R, DODD, Peter R, RANDALL, Patrick K, MAYFIELD, R. Dayne
• Format: Journal Article
• Language: English
• Published: New York, NY Nature Publishing 01.07.2006; Nature Publishing Group
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alcoholism; Alcoholism - metabolism; Alcoholism - pathology; Alcoholism - physiopathology; Alcoholism and acute alcohol poisoning; Biological and medical sciences; Case-Control Studies; Female; Frontal Lobe - physiology; Gene Expression - physiology; Gene Expression Profiling - methods; Gene Expression Regulation - physiology; Humans; Male; Medical sciences; Middle Aged; Oligonucleotide Array Sequence Analysis - methods; Postmortem Changes; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; RNA, Messenger - metabolism; Toxicology; Human; neural disease; Alcoholism; Central nervous system; DNA chip; Frontal cortex; Gene expression; Adhesion; In vitro; Encephalon; human brain; microarray; cell adhesion

Alcohol dependence is characterized by tolerance, physical dependence, and craving. The neuroadaptations underlying these effects of chronic alcohol abuse are likely due to altered gene expression. Previous gene expression studies using human post-mortem brain demonstrated that several gene families...