Trim33 mediates the proinflammatory function of Th17 cells

• Published in: The Journal of experimental medicine Vol. 215; no. 7; pp. 1853 - 1868
• Main Authors: Tanaka, Shinya, Jiang, Yu, Martinez, Gustavo J., Tanaka, Kentaro, Yan, Xiaowei, Kurosaki, Tomohiro, Kaartinen, Vesa, Feng, Xin-Hua, Tian, Qiang, Wang, Xiaohu, Dong, Chen
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 02.07.2018
• Subjects: Animals; Cell Differentiation; Chromatin - metabolism; Chromatin remodeling; Differentiation; Genetic Loci; Genome; Helper cells; Histones - metabolism; Humans; Inflammation; Inflammation - immunology; Inflammation - pathology; Interleukin 1; Interleukin 10; Interleukin 17; Interleukin-10 - metabolism; Interleukin-17 - metabolism; Lymphocytes; Lymphocytes T; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; Protein Processing, Post-Translational; Signaling; Smad2 protein; Smad2 Protein - metabolism; Smad4 protein; Smad4 Protein - metabolism; T-Lymphocytes, Regulatory - immunology; Th17 Cells - immunology; Transcription Factors - deficiency; Transcription Factors - metabolism; Transforming growth factor; Transforming growth factor-b; Up-Regulation

Transforming growth factor–β (TGF-β) regulates reciprocal regulatory T cell (T reg) and T helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Sma...