Somatostatin Primes Endothelial Cells for Agonist-Induced Hyperpermeability and Angiogenesis In Vitro

• Published in: International journal of molecular sciences Vol. 23; no. 6; p. 3098
• Main Authors: Aslam, Muhammad, Idrees, Hafiza, Ferdinandy, Peter, Helyes, Zsuzsanna, Hamm, Christian, Schulz, Rainer
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.03.2022; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; Akt; AKT protein; Angiogenesis; Cell proliferation; Cells, Cultured; Endothelial cells; endothelial permeability; Extracellular signal-regulated kinase; Growth factors; Hormones; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Kinases; MAP kinase; MAPK; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase Kinases - metabolism; Neovascularization, Pathologic - metabolism; Neurotransmission; Permeability; Phosphorylation; Proteins; Proto-Oncogene Proteins c-akt - metabolism; RhoA/Rock; Signal transduction; Smooth muscle; Somatostatin; Somatostatin - metabolism; Somatostatin - pharmacology; somatostatin receptors; Thrombin; Thrombin - metabolism; Thrombin - pharmacology; Tumors; Umbilical vein; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Vascular system; angiogenesis; MYPT1; somatostatin receptors; Akt; MAPK; cAMP; RhoA/Rock; endothelial permeability

Somatostatin is an inhibitory peptide, which regulates the release of several hormones, and affects neurotransmission and cell proliferation via its five G protein-coupled receptors (SST ). Although its endocrine regulatory and anti-tumour effects have been thoroughly studied, little is known about...