Exercise training and metformin, but not exercise training alone, decreases insulin production and increases insulin clearance in adults with prediabetes
Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to r...
Saved in:
| Published in | Journal of applied physiology (1985) Vol. 123; no. 1; pp. 243 - 248 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Physiological Society
01.07.2017
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M), exercise and placebo (E+P), or exercise and metformin (E+M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production), C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4 ± 10.1 vs. 22.6 ± 15.0 pmol/l), E+P (15.1 ± 7.4 vs. 15.5 ± 7.4 pmol/l), or M (24.8 ± 18.9 vs. 16.7 ± 20.3 pmol/l) but was significantly reduced after E+M (18.6 ± 11.9 vs. 13.9 ± 6.7 pmol/l; P = 0.04). Insulin clearance was significantly greater following M (384.6 ± 19.4 vs. 477.4 ± 49.9; P = 0.03) and E+M (400.1 ± 32.0 vs. 482.9 ± 33.9; P = 0.02) but was unchanged in P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed.
NEW & NOTEWORTHY Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a widely prescribed diabetes medication, may diminish the benefits of exercise when used in combination. In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. This may directly influence personalized prescriptions of lifestyle and/or pharmacology to reduce diabetes risk. |
|---|---|
| AbstractList | Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M), exercise and placebo (E+P), or exercise and metformin (E+M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production), C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4 ± 10.1 vs. 22.6 ± 15.0 pmol/l), E+P (15.1 ± 7.4 vs. 15.5 ± 7.4 pmol/l), or M (24.8 ± 18.9 vs. 16.7 ± 20.3 pmol/l) but was significantly reduced after E+M (18.6 ± 11.9 vs. 13.9 ± 6.7 pmol/l; P = 0.04). Insulin clearance was significantly greater following M (384.6 ± 19.4 vs. 477.4 ± 49.9; P = 0.03) and E+M (400.1 ± 32.0 vs. 482.9 ± 33.9; P = 0.02) but was unchanged in P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed.
NEW & NOTEWORTHY Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a widely prescribed diabetes medication, may diminish the benefits of exercise when used in combination. In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. This may directly influence personalized prescriptions of lifestyle and/or pharmacology to reduce diabetes risk. Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M), exercise and placebo (E+P), or exercise and metformin (E+M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production), C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4 ± 10.1 vs. 22.6 ± 15.0 pmol/l), E+P (15.1 ± 7.4 vs. 15.5 ± 7.4 pmol/l), or M (24.8 ± 18.9 vs. 16.7 ± 20.3 pmol/l) but was significantly reduced after E+M (18.6 ± 11.9 vs. 13.9 ± 6.7 pmol/l; = 0.04). Insulin clearance was significantly greater following M (384.6 ± 19.4 vs. 477.4 ± 49.9; = 0.03) and E+M (400.1 ± 32.0 vs. 482.9 ± 33.9; = 0.02) but was unchanged in P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed. Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a widely prescribed diabetes medication, may diminish the benefits of exercise when used in combination. In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. This may directly influence personalized prescriptions of lifestyle and/or pharmacology to reduce diabetes risk. Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a widely prescribed diabetes medication, may diminish the benefits of exercise when used in combination. In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. This may directly influence personalized prescriptions of lifestyle and/or pharmacology to reduce diabetes risk. Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M), exercise and placebo (E+P), or exercise and metformin (E+M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production), C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4 ± 10.1 vs. 22.6 ± 15.0 pmol/l), E+P (15.1 ± 7.4 vs. 15.5 ± 7.4 pmol/l), or M (24.8 ± 18.9 vs. 16.7 ± 20.3 pmol/l) but was significantly reduced after E+M (18.6 ± 11.9 vs. 13.9 ± 6.7 pmol/l; P = 0.04). Insulin clearance was significantly greater following M (384.6 ± 19.4 vs. 477.4 ± 49.9; P = 0.03) and E+M (400.1 ± 32.0 vs. 482.9 ± 33.9; P = 0.02) but was unchanged in P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed. NEW & NOTEWORTHY Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a widely prescribed diabetes medication, may diminish the benefits of exercise when used in combination. In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. This may directly influence personalized prescriptions of lifestyle and/or pharmacology to reduce diabetes risk. Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M). exercise and placebo (E+P), or exercise and metformin (E±M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production). C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4 +/- 10.1 vs. 22.6 +/- 15.0 pmol/l), E±P (15.1 +/- 7.4 vs. 15.5 +/- 7.4 pmol/l), or M (24.8 +/- 18.9 vs. 16.7 +/- 20.3 pmol/l) but was significantly reduced after E±M (18.6 +/- 11.9 vs. 13.9 +/- 6.7 pmol/l; P = 0.04). Insulin clearance was significantly greater following M (384.6 +/- 19.4 vs. 477.4 +/- 49.9; P = 0.03) and E±M (400.1 +/- 32.0 vs. 482.9 +/- 33.9; P = 0.02) but was unchanged in P or E±P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed. Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M), exercise and placebo (E+P), or exercise and metformin (E+M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production), C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4 ± 10.1 vs. 22.6 ± 15.0 pmol/l), E+P (15.1 ± 7.4 vs. 15.5 ± 7.4 pmol/l), or M (24.8 ± 18.9 vs. 16.7 ± 20.3 pmol/l) but was significantly reduced after E+M (18.6 ± 11.9 vs. 13.9 ± 6.7 pmol/l; P = 0.04). Insulin clearance was significantly greater following M (384.6 ± 19.4 vs. 477.4 ± 49.9; P = 0.03) and E+M (400.1 ± 32.0 vs. 482.9 ± 33.9; P = 0.02) but was unchanged in P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed.NEW & NOTEWORTHY Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a widely prescribed diabetes medication, may diminish the benefits of exercise when used in combination. In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. This may directly influence personalized prescriptions of lifestyle and/or pharmacology to reduce diabetes risk.Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M), exercise and placebo (E+P), or exercise and metformin (E+M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production), C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4 ± 10.1 vs. 22.6 ± 15.0 pmol/l), E+P (15.1 ± 7.4 vs. 15.5 ± 7.4 pmol/l), or M (24.8 ± 18.9 vs. 16.7 ± 20.3 pmol/l) but was significantly reduced after E+M (18.6 ± 11.9 vs. 13.9 ± 6.7 pmol/l; P = 0.04). Insulin clearance was significantly greater following M (384.6 ± 19.4 vs. 477.4 ± 49.9; P = 0.03) and E+M (400.1 ± 32.0 vs. 482.9 ± 33.9; P = 0.02) but was unchanged in P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed.NEW & NOTEWORTHY Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a widely prescribed diabetes medication, may diminish the benefits of exercise when used in combination. In this study, however, metformin combined with exercise training, but not exercise alone, lowered proinsulin concentrations and increased insulin clearance in adults with prediabetes. This may directly influence personalized prescriptions of lifestyle and/or pharmacology to reduce diabetes risk. Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin concentrations. Although lower insulin concentrations (lower supply) following lifestyle and/or pharmacological interventions are primarily attributed to reductions in insulin secretion that match increases in peripheral insulin sensitivity (lower demand), it is unclear whether exercise and/or metformin exert direct effects on insulin production, extraction, or clearance. Thirty-six middle-aged, obese, sedentary adults with prediabetes were randomized to placebo (P), metformin (M), exercise and placebo (E+P), or exercise and metformin (E+M) for 12 wk. Fasting plasma proinsulin (an indicator of insulin production), C-peptide, insulin, and glucose were collected before and after the intervention. Peripheral insulin sensitivity (euglycemic clamp), hepatic insulin extraction, insulin clearance, body weight, and cardiorespiratory fitness were also measured. Fasting proinsulin was unchanged following P (19.4±10.1 vs. 22.6±15.0 pmol/l), E+P (15.1±7.4 vs. 15.5±7.4 pmol/l), or M (24.8±18.9 vs. 16.7±20.3 pmol/l) but was significantly reduced after E+M (18.6±11.9 vs. 13.9±6.7 pmol/l; P = 0.04). Insulin clearance was significantly greater following M (384.6±19.4 vs. 477.4±49.9; P = 0.03) and E+M (400.1±32.0 vs. 482.9±33.9; P = 0.02) but was unchanged in P or E+P. In this study, metformin combined with exercise training reduced circulating proinsulin, and both groups taking metformin increased insulin clearance. This suggests that adding metformin to exercise may augment or attenuate training effects depending on the outcome or organ system being assessed. |
| Author | Braun, Barry Malin, Steven K. Viskochil, Richard Blankenship, Jennifer M. |
| Author_xml | – sequence: 1 givenname: Richard surname: Viskochil fullname: Viskochil, Richard organization: Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts – sequence: 2 givenname: Steven K. surname: Malin fullname: Malin, Steven K. organization: Department of Kinesiology, University of Virginia, Charlottesville, Virginia;, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia; and – sequence: 3 givenname: Jennifer M. surname: Blankenship fullname: Blankenship, Jennifer M. organization: Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts – sequence: 4 givenname: Barry surname: Braun fullname: Braun, Barry organization: Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts;, Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28473613$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFks1u1DAUhS1URKeFVwBLbLroDL6JEzsLkFBVfqRKbGBtOc5NxyOPHWyn0Efp2-LpDyrDoitLvt85vr7nHpEDHzwS8gbYCqCp3m30NLlpfZ1scCvGRMdWFYP2GVmUarWElsEBWUjRsKVopDgkRyltGAPOG3hBDivJRd1CvSA3578xGpuQ5qitt_6Saj_QLeYxxK31p7SfM_UhU_wfdKWpUzqgiagTJmp9mp31dIphmE22wd-aWb8PGIc6am-w3FA9zC4n-svmdVHiYHWPGdNL8nzULuGr-_OY_Ph0_v3sy_Li2-evZx8vloYLmZfA27HWZhgr3umhEwJMwzjvWtBSjtL00PWjFkbDCKYVuoceG26waLgc6qE-Jh_ufKe53-Jg0JcPOjVFu9XxWgVt1b8Vb9fqMlyppqmlhLoYnNwbxPBzxpTV1iaDzmmPYU6qAllG3dZcPomC7FrGS8KioG_30E2Yoy-TUNC1JT3ZsKpQrx83_7frh4AL8P4OMDGkFHFUxma9i2YXo1PA1G6h1OOFUrcLpXYLVfRiT__wxFPKPw-R2kY |
| CitedBy_id | crossref_primary_10_1155_2019_3428543 crossref_primary_10_1152_japplphysiol_00680_2018 crossref_primary_10_14814_phy2_16093 crossref_primary_10_31793_1680_1466_2020_25_2_143 crossref_primary_10_4103_cjp_cjp_87_21 crossref_primary_10_1007_s00592_020_01488_7 crossref_primary_10_1016_j_diabres_2022_109881 crossref_primary_10_1186_s13098_024_01504_8 crossref_primary_10_1016_j_smhs_2023_02_003 crossref_primary_10_1371_journal_pone_0197663 crossref_primary_10_3390_metabo12121286 crossref_primary_10_4239_wjd_v15_i3_361 crossref_primary_10_1177_0300060518817164 crossref_primary_10_1210_clinem_dgab255 crossref_primary_10_3389_fendo_2021_694099 crossref_primary_10_2174_1570161120666220107105840 crossref_primary_10_3389_fendo_2023_1233312 crossref_primary_10_1042_BCJ20210185 crossref_primary_10_1136_bjsports_2024_108127 |
| Cites_doi | 10.1002/oby.20625 10.1210/jcem.84.6.5717 10.1016/j.bcp.2004.04.003 10.1007/s00125-013-3134-3 10.1016/j.diabres.2013.12.031 10.1161/01.CIR.0000015855.04844.E7 10.2337/diabetes.53.11.2867 10.1152/japplphysiol.00936.2012 10.2337/dc10-9990 10.1074/jbc.M114.567271 10.1152/japplphysiol.00155.2013 10.2337/dc11-0925 10.1002/oby.20235 10.1038/nature13270 10.1007/s00592-013-0511-9 10.1007/BF00400421 10.1080/07315724.2003.10719326 10.1152/ajpendo.00421.2006 10.2337/diabetes.49.12.2116 10.1172/JCI40671 10.2337/diabetes.54.8.2404 10.1371/journal.pone.0077440 10.1210/jc.2011-0246 10.1017/S0007114511006623 10.2337/diacare.22.2.262 10.1055/s-2007-978730 10.2337/diacare.22.4.609 10.1152/ajpendo.00351.2006 10.1152/ajpendo.00532.2003 10.1007/s00125-011-2322-2 10.1152/ajpendo.00473.2004 |
| ContentType | Journal Article |
| Copyright | Copyright © 2017 the American Physiological Society. Copyright American Physiological Society Jul 2017 Copyright © 2017 the American Physiological Society 2017 American Physiological Society |
| Copyright_xml | – notice: Copyright © 2017 the American Physiological Society. – notice: Copyright American Physiological Society Jul 2017 – notice: Copyright © 2017 the American Physiological Society 2017 American Physiological Society |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QP 7QR 7TK 7TS 7U7 8FD C1K FR3 P64 7X8 5PM |
| DOI | 10.1152/japplphysiol.00790.2016 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Physical Education Index Toxicology Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Technology Research Database Toxicology Abstracts Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Physical Education Index Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE MEDLINE - Academic Technology Research Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| DocumentTitleAlternate | Exercise and Metformin in Prediabetes Viskochil R et al |
| EISSN | 1522-1601 |
| EndPage | 248 |
| ExternalDocumentID | PMC5538813 28473613 10_1152_japplphysiol_00790_2016 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grantid: 5 R56 DK081038 – fundername: American College of Sports Medicine Doctoral Student Grant |
| GroupedDBID | --- -~X .55 18M 29J 2WC 4.4 53G 5VS 85S AAFWJ AAYXX ABCQX ABDNZ ABHWK ABJNI ABKWE ABOCM ACBEA ACGFO ACGFS ACIWK ACPRK ADBBV ADFNX AEILP AENEX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS BAWUL BKKCC BTFSW CITATION CS3 DIK DU5 E3Z EBS EJD EMOBN F5P FRP GX1 H13 H~9 ITBOX KQ8 L7B OK1 P2P P6G PQQKQ RAP RHI RPL RPRKH SJN TR2 UHB UKR UPT W8F WH7 WOQ X7M XSW YBH YQT YWH ~02 CGR CUY CVF ECM EIF NPM 7QP 7QR 7TK 7TS 7U7 8FD C1K FR3 P64 7X8 5PM |
| ID | FETCH-LOGICAL-c478t-146f3acdf249ad9771c5044961a88f8cb19bfa7ca1f1c67ab1be54ce3ac48d3d3 |
| ISSN | 8750-7587 1522-1601 |
| IngestDate | Thu Aug 21 18:31:26 EDT 2025 Fri Jul 11 10:50:09 EDT 2025 Fri Jul 11 03:42:30 EDT 2025 Mon Jun 30 08:39:35 EDT 2025 Thu Apr 03 07:05:36 EDT 2025 Thu Apr 24 23:01:53 EDT 2025 Tue Jul 01 02:37:44 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | proinsulin hepatic extraction insulin secretion insulin clearance |
| Language | English |
| License | Copyright © 2017 the American Physiological Society. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c478t-146f3acdf249ad9771c5044961a88f8cb19bfa7ca1f1c67ab1be54ce3ac48d3d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00790.2016 |
| PMID | 28473613 |
| PQID | 1967368502 |
| PQPubID | 40905 |
| PageCount | 6 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5538813 proquest_miscellaneous_2186136348 proquest_miscellaneous_1896041157 proquest_journals_1967368502 pubmed_primary_28473613 crossref_citationtrail_10_1152_japplphysiol_00790_2016 crossref_primary_10_1152_japplphysiol_00790_2016 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2017-07-01 |
| PublicationDateYYYYMMDD | 2017-07-01 |
| PublicationDate_xml | – month: 07 year: 2017 text: 2017-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Bethesda – name: Bethesda, MD |
| PublicationTitle | Journal of applied physiology (1985) |
| PublicationTitleAlternate | J Appl Physiol (1985) |
| PublicationYear | 2017 |
| Publisher | American Physiological Society |
| Publisher_xml | – name: American Physiological Society |
| References | B20 B21 B22 B23 B24 B26 B27 B28 B29 Nijpels G (B25) 1996; 39 B30 B31 B10 B11 B12 B13 B14 B15 B16 B17 B18 B19 B1 B2 B3 B4 B5 B6 B7 B8 B9 24194886 - PLoS One. 2013 Oct 23;8(10):e77440 24326527 - Diabetologia. 2014 Mar;57(3):455-62 21115758 - Diabetes Care. 2010 Dec;33(12):e147-67 22040838 - Diabetes Care. 2012 Jan;35(1):131-6 10333943 - Diabetes Care. 1999 Feb;22(2):262-70 15242807 - Biochem Pharmacol. 2004 Aug 1;68(3):409-16 20577053 - J Clin Invest. 2010 Jul;120(7):2355-69 14684753 - J Am Coll Nutr. 2003 Dec;22(6):487-93 11118015 - Diabetes. 2000 Dec;49(12):2116-25 24928508 - J Biol Chem. 2014 Jul 25;289(30):20435-46 16046308 - Diabetes. 2005 Aug;54(8):2404-14 21959959 - Diabetologia. 2011 Dec;54(12):3047-54 11994248 - Circulation. 2002 May 7;105(18):2153-8 10189540 - Diabetes Care. 1999 Apr;22(4):609-14 10333082 - Horm Metab Res. 1999 Apr;31(4):267-70 24462282 - Diabetes Res Clin Pract. 2014 Apr;104(1):163-70 8720611 - Diabetologia. 1996 Jan;39(1):113-8 16144811 - Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E169-E176 17341552 - Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E1-E15 23505172 - Obesity (Silver Spring). 2013 Jan;21(1):93-100 22152054 - Br J Nutr. 2012 Oct;108(7):1155-62 24201706 - J Appl Physiol (1985). 2014 Feb 1;116(3):231-9 21697254 - J Clin Endocrinol Metab. 2011 Aug;96(8):2354-66 23019312 - J Appl Physiol (1985). 2012 Dec 15;113(12):1873-83 23989864 - Acta Diabetol. 2014 Apr;51(2):257-61 24123967 - Obesity (Silver Spring). 2014 May;22(5):1238-45 24847880 - Nature. 2014 Jun 26;510(7506):542-6 10372712 - J Clin Endocrinol Metab. 1999 Jun;84(6):2068-74 14871885 - Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31 17284579 - Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1581-9 15504967 - Diabetes. 2004 Nov;53(11):2867-72 |
| References_xml | – ident: B1 doi: 10.1002/oby.20625 – ident: B15 doi: 10.1210/jcem.84.6.5717 – ident: B10 doi: 10.1016/j.bcp.2004.04.003 – ident: B11 doi: 10.1007/s00125-013-3134-3 – ident: B23 doi: 10.1016/j.diabres.2013.12.031 – ident: B31 doi: 10.1161/01.CIR.0000015855.04844.E7 – ident: B28 doi: 10.2337/diabetes.53.11.2867 – ident: B9 doi: 10.1152/japplphysiol.00936.2012 – ident: B6 doi: 10.2337/dc10-9990 – ident: B2 doi: 10.1074/jbc.M114.567271 – ident: B14 doi: 10.1152/japplphysiol.00155.2013 – ident: B19 doi: 10.2337/dc11-0925 – ident: B20 doi: 10.1002/oby.20235 – ident: B18 doi: 10.1038/nature13270 – ident: B22 doi: 10.1007/s00592-013-0511-9 – volume: 39 start-page: 113 year: 1996 ident: B25 publication-title: Diabetologia doi: 10.1007/BF00400421 – ident: B29 doi: 10.1080/07315724.2003.10719326 – ident: B5 doi: 10.1152/ajpendo.00421.2006 – ident: B24 doi: 10.2337/diabetes.49.12.2116 – ident: B8 doi: 10.1172/JCI40671 – ident: B13 doi: 10.2337/diabetes.54.8.2404 – ident: B21 doi: 10.1371/journal.pone.0077440 – ident: B7 doi: 10.1210/jc.2011-0246 – ident: B3 doi: 10.1017/S0007114511006623 – ident: B30 doi: 10.2337/diacare.22.2.262 – ident: B4 doi: 10.1055/s-2007-978730 – ident: B26 doi: 10.2337/diacare.22.4.609 – ident: B12 doi: 10.1152/ajpendo.00351.2006 – ident: B16 doi: 10.1152/ajpendo.00532.2003 – ident: B17 doi: 10.1007/s00125-011-2322-2 – ident: B27 doi: 10.1152/ajpendo.00473.2004 – reference: 24326527 - Diabetologia. 2014 Mar;57(3):455-62 – reference: 17341552 - Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E1-E15 – reference: 15242807 - Biochem Pharmacol. 2004 Aug 1;68(3):409-16 – reference: 16046308 - Diabetes. 2005 Aug;54(8):2404-14 – reference: 23505172 - Obesity (Silver Spring). 2013 Jan;21(1):93-100 – reference: 14871885 - Am J Physiol Endocrinol Metab. 2004 Jun;286(6):E1023-31 – reference: 23019312 - J Appl Physiol (1985). 2012 Dec 15;113(12):1873-83 – reference: 21115758 - Diabetes Care. 2010 Dec;33(12):e147-67 – reference: 8720611 - Diabetologia. 1996 Jan;39(1):113-8 – reference: 23989864 - Acta Diabetol. 2014 Apr;51(2):257-61 – reference: 15504967 - Diabetes. 2004 Nov;53(11):2867-72 – reference: 10333943 - Diabetes Care. 1999 Feb;22(2):262-70 – reference: 24462282 - Diabetes Res Clin Pract. 2014 Apr;104(1):163-70 – reference: 24847880 - Nature. 2014 Jun 26;510(7506):542-6 – reference: 10372712 - J Clin Endocrinol Metab. 1999 Jun;84(6):2068-74 – reference: 16144811 - Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E169-E176 – reference: 14684753 - J Am Coll Nutr. 2003 Dec;22(6):487-93 – reference: 24194886 - PLoS One. 2013 Oct 23;8(10):e77440 – reference: 11118015 - Diabetes. 2000 Dec;49(12):2116-25 – reference: 11994248 - Circulation. 2002 May 7;105(18):2153-8 – reference: 20577053 - J Clin Invest. 2010 Jul;120(7):2355-69 – reference: 22152054 - Br J Nutr. 2012 Oct;108(7):1155-62 – reference: 10189540 - Diabetes Care. 1999 Apr;22(4):609-14 – reference: 24928508 - J Biol Chem. 2014 Jul 25;289(30):20435-46 – reference: 22040838 - Diabetes Care. 2012 Jan;35(1):131-6 – reference: 17284579 - Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1581-9 – reference: 24123967 - Obesity (Silver Spring). 2014 May;22(5):1238-45 – reference: 24201706 - J Appl Physiol (1985). 2014 Feb 1;116(3):231-9 – reference: 21959959 - Diabetologia. 2011 Dec;54(12):3047-54 – reference: 21697254 - J Clin Endocrinol Metab. 2011 Aug;96(8):2354-66 – reference: 10333082 - Horm Metab Res. 1999 Apr;31(4):267-70 |
| SSID | ssj0014451 |
| Score | 2.340984 |
| Snippet | Adding metformin to exercise does not augment the effect of training alone to boost whole body insulin sensitivity and lower circulating insulin... Exercise is increasingly viewed as medication, creating a need to understand its interactions with other common medications. Research suggests metformin, a... |
| SourceID | pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 243 |
| SubjectTerms | Adult Adults Antidiabetics Body weight Cardiorespiratory fitness Combined Modality Therapy - methods Diabetes Exercise - physiology Fasting Female Fitness Humans Hypoglycemic Agents - therapeutic use Impact analysis Insulin Insulin - blood Insulin secretion Male Metformin Metformin - therapeutic use Middle Aged Overweight - blood Overweight - therapy Pharmacology Physical training Prediabetic State - blood Prediabetic State - therapy Random Allocation Secretion Sedentary Lifestyle Sensitivity Studies Training Wellness programs |
| Title | Exercise training and metformin, but not exercise training alone, decreases insulin production and increases insulin clearance in adults with prediabetes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28473613 https://www.proquest.com/docview/1967368502 https://www.proquest.com/docview/1896041157 https://www.proquest.com/docview/2186136348 https://pubmed.ncbi.nlm.nih.gov/PMC5538813 |
| Volume | 123 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfGkBAvCDY-CgMZCfHSZcSJkziP0zQ0MRWBtKG9RY7jaNW6tFrTh_Gf8N9yZztu2jIBe6naxE6d3J3vI3e_I-SDVpJzXuqgkkoEvK5YUMpQB2XGIiXCWqUR1g6PvqYn5_zLRXKx9WC3l7W0aMsD9fOPdSX3oSocA7pilex_UNZfFA7Ad6AvfAKF4fOfaHzs-iX5Rg_mVcC1btESteAA5aIdNtPWt1bqDZ1MbTSzMpbj3GRm2cT0mYWB7TKVx836AIXNJkyxAfwwEB6uSm52o7to7h1mr3RmrwmpWAAoxIrKRdILSvwYz6-mWGe-VvtvY-eux7xtyDY8PfAhhYlsrrTJP-sn7gxHyxE3ctG41ywu_9lFPFjms2PbXpEBqohuoYadXZbrcv8ETywMwB2y-ly7_R18b5a6q3UKwFY8r3C6284thJSzDCKLCbqpdJLINDuA5-eeHQKy5yEmDqb9GcA9s2vDi2gUxCmLl1rY50Z-Gx0loIUEtmJ-GIHzg305Tr8v340hpJyNWtvbc1mLsIpPd6wBEa_dH66aXxs-1XpqcM_WOntKnjhuoYeW45-RLd3skN3DRrbT61v6kXqS3O6QRyOXHbJLfnXyQDsmp8C-1MvDPgVpoCANVG8ORGnYp14WqGN1upQFczEvC36AlwU4Qq0sUJQF2pOF5-T88_HZ0UngWo8EimeiDcB-qGOpqjriuazAR2IqCTnPUyaFqIUqWV7WMlOS1UylmSxZqROuNMzhooqr-AXZbmDdrwhlPK_qKuYqlQjcJMpciqhKwjplpeA8G5C0o0ihHC4_3vykMP55EhV9qhaGqgVSdUBCP3FmoWn-PmWvI3nh9rF5ATo4wzYUYTQg7_1p0DL46lA2erqAMQJBnBCY6-4x2N2OxWnMxYC8tFzk19Wx34BkK_zlByDK_eqZZnxp0O6dMLy-98w35PFyF9kj2-3NQr8FT6It3xnB-g2gPyy8 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Exercise+training+and+metformin%2C+but+not+exercise+training+alone%2C+decreases+insulin+production+and+increases+insulin+clearance+in+adults+with+prediabetes&rft.jtitle=Journal+of+applied+physiology+%281985%29&rft.au=Viskochil%2C+Richard&rft.au=Malin%2C+Steven+K.&rft.au=Blankenship%2C+Jennifer+M.&rft.au=Braun%2C+Barry&rft.date=2017-07-01&rft.pub=American+Physiological+Society&rft.issn=8750-7587&rft.eissn=1522-1601&rft.volume=123&rft.issue=1&rft.spage=243&rft.epage=248&rft_id=info:doi/10.1152%2Fjapplphysiol.00790.2016&rft_id=info%3Apmid%2F28473613&rft.externalDocID=PMC5538813 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=8750-7587&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=8750-7587&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=8750-7587&client=summon |