New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 12; p. 1623
• Main Authors: Duarte, Diana, Vale, Nuno
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2020; MDPI
• Subjects: Antimalarial agents; antimalarial drugs; Antimalarials - pharmacology; Antineoplastic Agents - pharmacology; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Antineoplastic drugs; Apoptosis; Artesunate; Artesunate - pharmacology; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer therapies; Cell cycle; Cell Proliferation - drug effects; Cell Survival - drug effects; Cell viability; Chemotherapy; Chloroquine; Chloroquine - pharmacology; Clinical medicine; combination therapy; Cytotoxicity; Deoxyribonucleic acid; DNA; Doxorubicin; Doxorubicin - pharmacology; Drug dosages; drug repurposing; Drug resistance; Drug Synergism; Estrogens; Female; Humans; Malaria; MCF-7 Cells; Mefloquine; Mefloquine - pharmacology; Metabolism; Metabolites; Paclitaxel; Paclitaxel - pharmacology; Parasites; Pharmaceutical industry; breast cancer; combination therapy; drug synergism; antimalarial drugs; drug repurposing; antineoplastic drugs

Chemotherapy plays a key role in breast cancer therapy, but drug resistance and unwanted side effects make the treatment less effective. We propose a new combination model that combines antineoplastic drugs and antimalarials for breast cancer therapy. Cytotoxic effects of two antineoplastic agents a...