Influence of Critical Parameters on Cytotoxicity Induced by Mesoporous Silica Nanoparticles

Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed to be satisfactory, is unclear. Physicochemica...

Full description

Saved in:
Bibliographic Details
Published inNanomaterials (Basel, Switzerland) Vol. 12; no. 12; p. 2016
Main Authors Ahmadi, Amirsadra, Sokunbi, Moses, Patel, Trisha, Chang, Ming-Wei, Ahmad, Zeeshan, Singh, Neenu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.06.2022
MDPI
Subjects
Bioavailability
Biocompatibility
Biomedical materials
Cell viability
Cytotoxicity
Diameters
functionalisation
Investigations
mesoporous silica nanoparticles
Morphology
Nanomaterials
Nanoparticles
nanotoxicology
Outliers (statistics)
Parameters
Physicochemical properties
Pore size
Silica
Silicon dioxide
Statistical analysis
Surface charge
Surface chemistry
Surface stability
Thermal stability
Toxicity
Zeta potential
toxicity
mesoporous silica nanoparticles
diameter size
incubation
functionalisation
zeta potential
cytotoxicity
nanotoxicology
Online AccessGet full text

Cover

Abstract Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed to be satisfactory, is unclear. Physicochemical properties of MSNs, such as diameter size, morphology, and surface charge, control their biological interactions and toxicity. Experimental conditions also play an essential role in influencing toxicological results. Therefore, the present study includes studies from the last five years to statistically analyse the effect of various physicochemical features on MSN-induced in-vitro cytotoxicity profiles. Due to non-normally distributed data and the presence of outliers, a Kruskal–Wallis H test was conducted on different physicochemical characteristics, including diameter sizes, zeta-potential measurements, and functionalisation of MSNs, based on the viability results, and statistical differences were obtained. Subsequently, pairwise comparisons were performed using Dunn’s procedure with a Bonferroni correction for multiple comparisons. Other experimental parameters, such as type of cell line used, cell viability measurement assay, and incubation time, were also explored and analysed for statistically significant results.
AbstractList Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed to be satisfactory, is unclear. Physicochemical properties of MSNs, such as diameter size, morphology, and surface charge, control their biological interactions and toxicity. Experimental conditions also play an essential role in influencing toxicological results. Therefore, the present study includes studies from the last five years to statistically analyse the effect of various physicochemical features on MSN-induced in-vitro cytotoxicity profiles. Due to non-normally distributed data and the presence of outliers, a Kruskal–Wallis H test was conducted on different physicochemical characteristics, including diameter sizes, zeta-potential measurements, and functionalisation of MSNs, based on the viability results, and statistical differences were obtained. Subsequently, pairwise comparisons were performed using Dunn’s procedure with a Bonferroni correction for multiple comparisons. Other experimental parameters, such as type of cell line used, cell viability measurement assay, and incubation time, were also explored and analysed for statistically significant results.
Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed to be satisfactory, is unclear. Physicochemical properties of MSNs, such as diameter size, morphology, and surface charge, control their biological interactions and toxicity. Experimental conditions also play an essential role in influencing toxicological results. Therefore, the present study includes studies from the last five years to statistically analyse the effect of various physicochemical features on MSN-induced in-vitro cytotoxicity profiles. Due to non-normally distributed data and the presence of outliers, a Kruskal-Wallis H test was conducted on different physicochemical characteristics, including diameter sizes, zeta-potential measurements, and functionalisation of MSNs, based on the viability results, and statistical differences were obtained. Subsequently, pairwise comparisons were performed using Dunn's procedure with a Bonferroni correction for multiple comparisons. Other experimental parameters, such as type of cell line used, cell viability measurement assay, and incubation time, were also explored and analysed for statistically significant results.Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size, surface chemistry, and thermal stability. The biocompatibility of MSNs, although generally believed to be satisfactory, is unclear. Physicochemical properties of MSNs, such as diameter size, morphology, and surface charge, control their biological interactions and toxicity. Experimental conditions also play an essential role in influencing toxicological results. Therefore, the present study includes studies from the last five years to statistically analyse the effect of various physicochemical features on MSN-induced in-vitro cytotoxicity profiles. Due to non-normally distributed data and the presence of outliers, a Kruskal-Wallis H test was conducted on different physicochemical characteristics, including diameter sizes, zeta-potential measurements, and functionalisation of MSNs, based on the viability results, and statistical differences were obtained. Subsequently, pairwise comparisons were performed using Dunn's procedure with a Bonferroni correction for multiple comparisons. Other experimental parameters, such as type of cell line used, cell viability measurement assay, and incubation time, were also explored and analysed for statistically significant results.
Author Ahmad, Zeeshan
Patel, Trisha
Sokunbi, Moses
Chang, Ming-Wei
Ahmadi, Amirsadra
Singh, Neenu
AuthorAffiliation 3 Leicester School of Pharmaceutical Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK; zahmad@dmu.ac.uk
2 Nanotechnology and Integrated Bioengineering Centre, Jordanstown Campus, University of Ulster, Newtownabbey BT37 0QB, UK; m.chang@ulster.ac.uk
1 Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK; p2569486@alumni365.dmu.ac.uk (A.A.); moses.sokunbi@dmu.ac.uk (M.S.); p17197170@my365.dmu.ac.uk (T.P.)
AuthorAffiliation_xml – name: 3 Leicester School of Pharmaceutical Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK; zahmad@dmu.ac.uk
– name: 2 Nanotechnology and Integrated Bioengineering Centre, Jordanstown Campus, University of Ulster, Newtownabbey BT37 0QB, UK; m.chang@ulster.ac.uk
– name: 1 Leicester School of Allied Health Sciences, De Montfort University, The Gateway, Leicester LE1 9BH, UK; p2569486@alumni365.dmu.ac.uk (A.A.); moses.sokunbi@dmu.ac.uk (M.S.); p17197170@my365.dmu.ac.uk (T.P.)
Author_xml – sequence: 1
  givenname: Amirsadra
  surname: Ahmadi
  fullname: Ahmadi, Amirsadra
– sequence: 2
  givenname: Moses
  orcidid: 0000-0002-8389-4577
  surname: Sokunbi
  fullname: Sokunbi, Moses
– sequence: 3
  givenname: Trisha
  surname: Patel
  fullname: Patel, Trisha
– sequence: 4
  givenname: Ming-Wei
  orcidid: 0000-0002-0137-8895
  surname: Chang
  fullname: Chang, Ming-Wei
– sequence: 5
  givenname: Zeeshan
  surname: Ahmad
  fullname: Ahmad, Zeeshan
– sequence: 6
  givenname: Neenu
  surname: Singh
  fullname: Singh, Neenu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35745355$$D View this record in MEDLINE/PubMed
BookMark eNptksuPFCEQxolZ467r3jwbEi8eHOXVDVxMzMTHJOsjUU8eCNDVK5MeGIE2zn8v68ya2Y1cgOJXXz6q6iE6iSkCQo8pecG5Ji-jjYkyyhih_T10xojUC6E1PTk6n6KLUtakLU256vgDdMo7KTredWfo-yqO0wzRA04jXuZQg7cT_myz3UCFXHCKeLmrqabfwYe6w6s4zB4G7Hb4A5S0TTnNBX8JU0vEH5ufrc1NZILyCN0f7VTg4rCfo29v33xdvl9cfnq3Wr6-XHghVV1QygehlbZSgFKEE9F3lgBQ7iVIaqnuFQfNpRYDjE7Qwavec-E6oWUL83O02usOya7NNoeNzTuTbDB_AylfmYMlIxxVzoGSgyTCeWlHR0H1ol1kD0I0rVd7re3sNjB4iDXb6Zbo7ZcYfpir9MtoxhShugk8Owjk9HOGUs0mFA_TZCO0QhnWK0q4UIw19OkddJ3mHFupGiXb3xraNerJsaN_Vm562AC2B3xOpWQYTeuTrSFdGwyTocRcz4o5npWW9PxO0o3uf_E_u06_nw
CitedBy_id crossref_primary_10_1002_slct_202400450
crossref_primary_10_3390_ijms24076349
crossref_primary_10_1002_cbic_202200672
crossref_primary_10_1016_j_jobab_2023_09_001
crossref_primary_10_1002_smll_202401787
crossref_primary_10_1021_acs_langmuir_4c02871
crossref_primary_10_1016_j_molliq_2025_127368
crossref_primary_10_1016_j_etap_2025_104638
crossref_primary_10_1016_j_ijpharm_2024_123852
crossref_primary_10_2147_IJN_S397626
crossref_primary_10_1016_j_mtbio_2024_101229
crossref_primary_10_1016_j_colsurfb_2024_113758
crossref_primary_10_3390_molecules28073194
crossref_primary_10_1080_10717544_2024_2381340
crossref_primary_10_3389_fbioe_2023_1332993
Cites_doi 10.1039/C7TB02429K
10.1016/j.talanta.2013.01.037
10.1073/pnas.1919755117
10.3389/fbioe.2020.599454
10.1016/j.ejps.2016.10.019
10.1021/acsami.6b11802
10.1016/j.msec.2019.01.129
10.1016/j.nano.2017.11.021
10.1039/C0MB00109K
10.1038/s41598-021-92419-1
10.1186/s13046-017-0492-6
10.1016/j.biopha.2018.10.167
10.1016/j.tiv.2010.01.001
10.1016/j.colsurfb.2018.02.015
10.1080/03639045.2018.1438467
10.1021/acs.molpharmaceut.6b00190
10.1021/tx700326b
10.1016/j.tox.2012.05.010
10.1371/journal.pone.0160705
10.1016/j.etap.2012.05.014
10.1038/s41598-017-09312-z
10.1007/s00204-010-0642-5
10.1016/j.biomaterials.2007.03.006
10.1007/978-1-60327-198-1_4
10.2147/IJN.S224183
10.1155/2018/5280736
10.1021/acsnano.8b04910
10.1016/j.biomaterials.2012.10.072
10.1002/smll.201301004
10.1186/2050-7771-2-1
10.1016/j.taap.2006.10.004
10.1016/j.ijpharm.2017.01.031
10.1021/acs.molpharmaceut.8b01073
10.1016/j.nano.2019.102041
10.1126/science.1114397
10.1152/ajplung.00277.2005
10.1016/j.msec.2020.111239
10.1016/j.actbio.2016.01.017
10.3390/pharmaceutics12060487
10.1186/1477-3155-9-29
10.1016/j.ijpharm.2017.12.039
10.1371/journal.pone.0231634
10.1124/jpet.118.253682
10.1007/978-1-60327-198-1_2
10.1021/acsami.8b06275
10.1080/01480545.2019.1571503
10.1021/acsami.7b05278
10.1021/am4014693
10.1021/ja0645943
10.2147/IJN.S195504
10.3390/pharmaceutics14010056
10.1021/acsomega.8b00427
10.1016/j.colsurfb.2019.03.019
10.3390/pharmaceutics13020184
10.1016/j.tiv.2018.06.019
10.3389/fmats.2020.00036
10.2147/IJN.S143293
10.1016/j.ijbiomac.2021.09.188
10.1039/C5TB02709H
10.1289/ehp.7339
10.1016/j.apsb.2018.01.007
10.3109/17435390.2011.626538
10.1002/adhm.201700012
10.1186/s11671-019-3208-3
10.1016/j.xphs.2020.09.026
10.1021/acsami.7b00411
10.1158/0008-5472.CAN-16-1681
10.3389/fphar.2020.00898
10.1016/j.pdpdt.2020.101770
10.1021/acsami.8b06998
10.3390/nano8121028
10.1021/acsami.6b12647
10.1007/s00775-019-01640-x
10.2174/2211738506666181031160108
10.1039/C6NR08282C
10.1039/C4NR06420H
10.1073/pnas.0510146103
10.1183/09031936.00178308
10.1016/j.ejps.2015.12.014
10.1016/j.actbio.2019.06.033
10.1038/cddis.2015.367
10.1073/pnas.88.12.5413
10.1021/bc500452y
10.3109/07388551.2012.685860
10.1002/smll.201402331
10.1021/acsami.7b05359
10.2147/IJN.S177109
10.1002/smll.200800461
10.1016/j.jhazmat.2020.124502
10.1016/j.actbio.2017.11.007
10.1016/j.tiv.2016.09.012
10.1016/j.ijpharm.2016.01.068
10.1039/C6TB01329E
10.1166/jbn.2016.2318
10.2147/IJN.S133832
10.1093/toxsci/kfr206
10.1111/1523-1747.ep12340708
10.1016/j.colsurfb.2020.110824
10.2147/IJN.S276105
10.3390/ma11081310
10.3390/polym10040390
10.1096/fj.02-0088com
10.1007/978-1-60327-198-1_6
10.1021/nn103077k
10.1080/03639045.2019.1629688
10.1016/j.tiv.2015.09.030
10.1038/sj.onc.1203176
10.3389/fbioe.2020.00170
10.1038/onc.2015.262
10.1016/j.actbio.2018.05.022
10.1021/acs.analchem.9b00633
10.1080/21691401.2018.1473412
10.1016/j.tiv.2011.05.003
10.1002/humu.23035
10.1016/j.tiv.2009.02.007
ContentType Journal Article
Copyright 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2022 by the authors. 2022
Copyright_xml – notice: 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2022 by the authors. 2022
DBID AAYXX
CITATION
NPM
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
8BQ
8FD
8FE
8FG
8FH
ABJCF
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
CCPQU
D1I
DWQXO
F28
FR3
GNUQQ
H8D
H8G
HCIFZ
JG9
JQ2
KB.
KR7
L7M
LK8
L~C
L~D
M7P
P64
PDBOC
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.3390/nano12122016
DatabaseName CrossRef
PubMed
Aluminium Industry Abstracts
Biotechnology Research Abstracts
Ceramic Abstracts
Computer and Information Systems Abstracts
Corrosion Abstracts
Electronics & Communications Abstracts
Engineered Materials Abstracts
Materials Business File
Mechanical & Transportation Engineering Abstracts
Solid State and Superconductivity Abstracts
METADEX
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection (via ProQuest SciTech Premium Collection)
Natural Science Collection
ProQuest One Community College
ProQuest Materials Science Collection
ProQuest Central Korea
ANTE: Abstracts in New Technology & Engineering
Engineering Research Database
ProQuest Central Student
Aerospace Database
Copper Technical Reference Library
SciTech Premium Collection (via ProQuest)
Materials Research Database
ProQuest Computer Science Collection
Materials Science Database
Civil Engineering Abstracts
Advanced Technologies Database with Aerospace
ProQuest Biological Science Collection
Computer and Information Systems Abstracts – Academic
Computer and Information Systems Abstracts Professional
Biological Science Database
Biotechnology and BioEngineering Abstracts
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
Publicly Available Content Database
Materials Research Database
ProQuest Central Student
ProQuest Central Essentials
ProQuest Computer Science Collection
Computer and Information Systems Abstracts
SciTech Premium Collection
ProQuest Central China
Materials Business File
ProQuest One Applied & Life Sciences
Engineered Materials Abstracts
Natural Science Collection
Biological Science Collection
ProQuest Central (New)
ANTE: Abstracts in New Technology & Engineering
Aluminium Industry Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Electronics & Communications Abstracts
ProQuest Technology Collection
Ceramic Abstracts
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest One Academic UKI Edition
Solid State and Superconductivity Abstracts
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
Technology Collection
Technology Research Database
Computer and Information Systems Abstracts – Academic
ProQuest One Academic Middle East (New)
Mechanical & Transportation Engineering Abstracts
Materials Science Collection
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central
Aerospace Database
Copper Technical Reference Library
Biotechnology Research Abstracts
ProQuest Central Korea
Materials Science Database
Advanced Technologies Database with Aerospace
ProQuest Materials Science Collection
Civil Engineering Abstracts
ProQuest SciTech Collection
METADEX
Computer and Information Systems Abstracts Professional
Materials Science & Engineering Collection
Corrosion Abstracts
MEDLINE - Academic
DatabaseTitleList CrossRef
PubMed
MEDLINE - Academic


Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 2079-4991
ExternalDocumentID oai_doaj_org_article_4b18bbe87d704bc7afb1e86404b76e44
PMC9228019
35745355
10_3390_nano12122016
Genre Journal Article
GroupedDBID 53G
5VS
8FE
8FG
8FH
AADQD
AAFWJ
AAHBH
AAYXX
ABJCF
ADBBV
ADMLS
AENEX
AFKRA
AFPKN
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
CCPQU
CITATION
D1I
GROUPED_DOAJ
HCIFZ
HYE
I-F
IAO
ITC
KB.
KQ8
LK8
M7P
MODMG
M~E
OK1
PDBOC
PGMZT
PHGZM
PHGZT
PIMPY
PROAC
RPM
NPM
PQGLB
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7U5
8BQ
8FD
ABUWG
AZQEC
DWQXO
F28
FR3
GNUQQ
H8D
H8G
JG9
JQ2
KR7
L7M
L~C
L~D
P64
PKEHL
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c478t-113d4989a74e88030465a0ee13c7e71a19683e93794defb41dc86c34b54979373
IEDL.DBID BENPR
ISSN 2079-4991
IngestDate Wed Aug 27 01:26:45 EDT 2025
Thu Aug 21 18:17:23 EDT 2025
Thu Jul 10 23:50:43 EDT 2025
Fri Jul 25 11:49:28 EDT 2025
Mon Jul 21 05:58:22 EDT 2025
Tue Jul 01 00:51:16 EDT 2025
Thu Apr 24 22:58:54 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords toxicity
mesoporous silica nanoparticles
diameter size
incubation
functionalisation
zeta potential
cytotoxicity
nanotoxicology
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c478t-113d4989a74e88030465a0ee13c7e71a19683e93794defb41dc86c34b54979373
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-0137-8895
0000-0002-8389-4577
OpenAccessLink https://www.proquest.com/docview/2679796815?pq-origsite=%requestingapplication%
PMID 35745355
PQID 2679796815
PQPubID 2032354
ParticipantIDs doaj_primary_oai_doaj_org_article_4b18bbe87d704bc7afb1e86404b76e44
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9228019
proquest_miscellaneous_2681034822
proquest_journals_2679796815
pubmed_primary_35745355
crossref_citationtrail_10_3390_nano12122016
crossref_primary_10_3390_nano12122016
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20220611
PublicationDateYYYYMMDD 2022-06-11
PublicationDate_xml – month: 6
  year: 2022
  text: 20220611
  day: 11
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Nanomaterials (Basel, Switzerland)
PublicationTitleAlternate Nanomaterials (Basel)
PublicationYear 2022
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References ref_94
Ali (ref_28) 2020; 188
Vrana (ref_117) 1999; 18
Feng (ref_5) 2019; 16
Nguyen (ref_46) 2017; 9
Ban (ref_122) 2020; 117
Kienzle (ref_48) 2017; 6
ref_18
Guo (ref_35) 2016; 4
Nabeshi (ref_67) 2010; 65
Sun (ref_2) 2019; 14
ref_16
Xie (ref_33) 2016; 83
Wang (ref_29) 2019; 45
Panyam (ref_93) 2002; 16
Song (ref_113) 2009; 34
ref_25
Zhang (ref_38) 2016; 76
Jin (ref_1) 2018; 3
Thi (ref_8) 2019; 99
Hecke (ref_17) 2012; 15
Zou (ref_39) 2016; 37
ref_124
Zhao (ref_20) 2019; 179
Braun (ref_60) 2018; 52
Yazdimamaghani (ref_86) 2019; 21
Patil (ref_71) 2012; 34
Li (ref_58) 2018; 46
Kim (ref_105) 2019; 14
Albers (ref_70) 2013; 7
Laaksonen (ref_85) 2007; 20
Kundu (ref_23) 2020; 116
Li (ref_40) 2017; 96
Ishimine (ref_116) 2018; 2018
You (ref_37) 2016; 4
Manaia (ref_13) 2017; 12
Moore (ref_47) 2016; 12
Li (ref_66) 2011; 25
Saroj (ref_56) 2018; 44
ref_83
Hsiao (ref_97) 2014; 5
Lu (ref_62) 2018; 13
Weiss (ref_69) 2011; 85
Cohen (ref_102) 2016; 35
Jafari (ref_64) 2019; 109
Kipen (ref_73) 2005; 289
McNeil (ref_10) 2011; Volume 697
ref_89
Gounani (ref_55) 2018; 537
Aliyandi (ref_121) 2020; 8
Mohamed (ref_106) 2011; 9
Chauhan (ref_14) 2019; 6
Hou (ref_59) 2018; 10
Zhang (ref_27) 2020; 8
Cha (ref_77) 2007; 17
Slowing (ref_95) 2006; 128
Chen (ref_115) 2021; 192
Passagne (ref_109) 2012; 299
Paatero (ref_51) 2017; 7
McNeil (ref_11) 2011; Volume 697
(ref_74) 2005; 113
Blechinger (ref_110) 2013; 9
Tzankova (ref_4) 2019; 44
Dong (ref_65) 2020; 15
Mohammadpour (ref_15) 2019; 370
Deng (ref_24) 2021; 409
Napierska (ref_68) 2009; 5
Yan (ref_22) 2020; 11
Henseleit (ref_114) 1997; 109
Zhao (ref_80) 2011; 5
Chen (ref_42) 2016; 8
Gaidano (ref_96) 1991; 88
Fei (ref_44) 2017; 519
Nel (ref_75) 2006; 311
Paris (ref_34) 2016; 33
Guo (ref_61) 2018; 10
Yang (ref_112) 2014; 2
Wu (ref_21) 2019; 96
Lin (ref_79) 2006; 217
Ferrauto (ref_41) 2017; 9
Liu (ref_49) 2017; 9
Zhou (ref_91) 2018; 8
Shapero (ref_107) 2011; 7
Zhou (ref_45) 2017; 36
Hei (ref_54) 2017; 5
Yang (ref_32) 2019; 14
Niculescu (ref_9) 2020; 7
Li (ref_101) 2016; 501
McNeil (ref_12) 2011; Volume 697
Fisichella (ref_84) 2009; 23
Tran (ref_57) 2018; 74
Kettiger (ref_81) 2015; 30
Yazdimamaghani (ref_88) 2018; 14
Ye (ref_87) 2010; 24
Zheng (ref_104) 2014; 25
Zhu (ref_108) 2013; 107
Pietruska (ref_72) 2011; 124
ref_30
Velletri (ref_119) 2016; 7
(ref_78) 2012; 7
Wright (ref_19) 2021; 110
Elle (ref_36) 2016; 13
Li (ref_90) 2013; 34
Yuan (ref_103) 2015; 7
Breznan (ref_63) 2018; 12
Noghreiyan (ref_26) 2020; 30
Lozano (ref_53) 2018; 65
Douroumis (ref_92) 2013; 33
Wan (ref_3) 2019; 91
Chou (ref_50) 2017; 9
Liu (ref_118) 2006; 103
Chung (ref_98) 2007; 28
Cheng (ref_43) 2017; 9
Li (ref_52) 2017; 12
Choi (ref_99) 2018; 165
Paula (ref_123) 2013; 5
Morishige (ref_76) 2010; 65
Benezra (ref_100) 2015; 11
Bouaoun (ref_120) 2016; 37
Pronsato (ref_111) 2013; 37
Abbasi (ref_82) 2021; 11
ref_7
ref_6
Edeler (ref_31) 2019; 24
References_xml – volume: 5
  start-page: 9497
  year: 2017
  ident: ref_54
  article-title: Dually Responsive Mesoporous Silica Nanoparticles Regulated by Upper Critical Solution Temperature Polymers for Intracellular Drug Delivery
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C7TB02429K
– volume: 107
  start-page: 408
  year: 2013
  ident: ref_108
  article-title: Size-Dependent Cellular Uptake Efficiency, Mechanism, and Cytotoxicity of Silica Nanoparticles toward HeLa Cells
  publication-title: Talanta
  doi: 10.1016/j.talanta.2013.01.037
– volume: 117
  start-page: 10492
  year: 2020
  ident: ref_122
  article-title: Machine Learning Predicts the Functional Composition of the Protein Corona and the Cellular Recognition of Nanoparticles
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1919755117
– volume: 8
  start-page: 599454
  year: 2020
  ident: ref_121
  article-title: Disentangling Biomolecular Corona Interactions with Cell Receptors and Implications for Targeting of Nanomedicines
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2020.599454
– volume: 96
  start-page: 456
  year: 2017
  ident: ref_40
  article-title: PH-Sensitive Mesoporous Silica Nanoparticles Anticancer Prodrugs for Sustained Release of Ursolic Acid and the Enhanced Anti-Cancer Efficacy for Hepatocellular Carcinoma Cancer
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2016.10.019
– volume: 8
  start-page: 33829
  year: 2016
  ident: ref_42
  article-title: Multifunctional Redox-Responsive Mesoporous Silica Nanoparticles for Efficient Targeting Drug Delivery and Magnetic Resonance Imaging
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.6b11802
– volume: 99
  start-page: 631
  year: 2019
  ident: ref_8
  article-title: Functionalized Mesoporous Silica Nanoparticles and Biomedical Applications
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2019.01.129
– volume: 14
  start-page: 533
  year: 2018
  ident: ref_88
  article-title: Global Gene Expression Analysis of Macrophage Response Induced by Nonporous and Porous Silica Nanoparticles
  publication-title: Nanomed. Nanotechnol. Biol. Med.
  doi: 10.1016/j.nano.2017.11.021
– volume: 7
  start-page: 371
  year: 2011
  ident: ref_107
  article-title: Time and Space Resolved Uptake Study of Silica Nanoparticles by Human Cells
  publication-title: Mol. Biosyst.
  doi: 10.1039/C0MB00109K
– volume: 11
  start-page: 15133
  year: 2021
  ident: ref_82
  article-title: The Synergistic Interference Effect of Silica Nanoparticles Concentration and the Wavelength of ELISA on the Colorimetric Assay of Cell Toxicity
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-92419-1
– volume: 36
  start-page: 24
  year: 2017
  ident: ref_45
  article-title: Intracellular PH-Responsive and Rituximab-Conjugated Mesoporous Silica Nanoparticles for Targeted Drug Delivery to Lymphoma B Cells
  publication-title: J. Exp. Clin. Cancer Res.
  doi: 10.1186/s13046-017-0492-6
– volume: 109
  start-page: 1100
  year: 2019
  ident: ref_64
  article-title: Mesoporous Silica Nanoparticles for Therapeutic/Diagnostic Applications
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2018.10.167
– volume: 24
  start-page: 751
  year: 2010
  ident: ref_87
  article-title: Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line
  publication-title: Toxicol. Vitr.
  doi: 10.1016/j.tiv.2010.01.001
– ident: ref_16
– volume: 165
  start-page: 56
  year: 2018
  ident: ref_99
  article-title: PEGylated Polyaminoacid-Capped Mesoporous Silica Nanoparticles for Mitochondria-Targeted Delivery of Celastrol in Solid Tumors
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2018.02.015
– volume: 44
  start-page: 1198
  year: 2018
  ident: ref_56
  article-title: Tailor-Made PH-Sensitive Polyacrylic Acid Functionalized Mesoporous Silica Nanoparticles for Efficient and Controlled Delivery of Anti-Cancer Drug Etoposide
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2018.1438467
– volume: 13
  start-page: 2647
  year: 2016
  ident: ref_36
  article-title: Functionalized Mesoporous Silica Nanoparticle with Antioxidants as a New Carrier That Generates Lower Oxidative Stress Impact on Cells
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.6b00190
– volume: 65
  start-page: 596
  year: 2010
  ident: ref_76
  article-title: Cytotoxicity of Amorphous Silica Particles against Macrophage-like THP-1 Cells Depends on Particle-Size and Surface Properties
  publication-title: Die Pharm-An Int. J. Pharm. Sci.
– volume: 20
  start-page: 1913
  year: 2007
  ident: ref_85
  article-title: Failure of MTT as a Toxicity Testing Agent for Mesoporous Silicon Microparticles
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx700326b
– volume: 299
  start-page: 112
  year: 2012
  ident: ref_109
  article-title: Implication of Oxidative Stress in Size-Dependent Toxicity of Silica Nanoparticles in Kidney Cells
  publication-title: Toxicology
  doi: 10.1016/j.tox.2012.05.010
– ident: ref_7
  doi: 10.1371/journal.pone.0160705
– volume: 34
  start-page: 436
  year: 2012
  ident: ref_71
  article-title: Evaluation of Cytotoxic, Oxidative Stress, Proinflammatory and Genotoxic Responses of Micro- and Nano-Particles of Dolomite on Human Lung Epithelial Cells A(549)
  publication-title: Environ. Toxicol. Pharmacol.
  doi: 10.1016/j.etap.2012.05.014
– volume: 7
  start-page: 8423
  year: 2017
  ident: ref_51
  article-title: Analyses in Zebrafish Embryos Reveal That Nanotoxicity Profiles Are Dependent on Surface-Functionalization Controlled Penetrance of Biological Membranes
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-09312-z
– volume: 85
  start-page: 813
  year: 2011
  ident: ref_69
  article-title: Uptake and Intracellular Localization of Submicron and Nano-Sized SiO₂ Particles in HeLa Cells
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-010-0642-5
– volume: 28
  start-page: 2959
  year: 2007
  ident: ref_98
  article-title: The Effect of Surface Charge on the Uptake and Biological Function of Mesoporous Silica Nanoparticles in 3T3-L1 Cells and Human Mesenchymal Stem Cells
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2007.03.006
– volume: Volume 697
  start-page: 35
  year: 2011
  ident: ref_10
  article-title: Measuring the Hydrodynamic Size of Nanoparticles in Aqueous Media Using Batch-Mode Dynamic Light Scattering
  publication-title: Characterization of Nanoparticles Intended for Drug Delivery
  doi: 10.1007/978-1-60327-198-1_4
– volume: 14
  start-page: 7375
  year: 2019
  ident: ref_105
  article-title: A reliable approach for assessing size-dependent effects of silica nanoparticles on cellular internalization behavior and cytotoxic mechanisms
  publication-title: Int. J. Nanomedicine
  doi: 10.2147/IJN.S224183
– volume: 2018
  start-page: 5280736
  year: 2018
  ident: ref_116
  article-title: The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer
  publication-title: Dis. Markers
  doi: 10.1155/2018/5280736
– volume: 12
  start-page: 12062
  year: 2018
  ident: ref_63
  article-title: Physicochemical Properties Can Be Key Determinants of Mesoporous Silica Nanoparticle Potency in Vitro
  publication-title: ACS Nano
  doi: 10.1021/acsnano.8b04910
– volume: 34
  start-page: 1391
  year: 2013
  ident: ref_90
  article-title: A Mesoporous Silica Nanoparticle--PEI--Fusogenic Peptide System for SiRNA Delivery in Cancer Therapy
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2012.10.072
– volume: 9
  start-page: 3970
  year: 2013
  ident: ref_110
  article-title: Uptake Kinetics and Nanotoxicity of Silica Nanoparticles Are Cell Type Dependent
  publication-title: Small Weinh. Bergstr. Ger.
  doi: 10.1002/smll.201301004
– volume: 2
  start-page: 1
  year: 2014
  ident: ref_112
  article-title: Monocyte and Macrophage Differentiation: Circulation Inflammatory Monocyte as Biomarker for Inflammatory Diseases
  publication-title: Biomark. Res.
  doi: 10.1186/2050-7771-2-1
– volume: 217
  start-page: 252
  year: 2006
  ident: ref_79
  article-title: In Vitro Toxicity of Silica Nanoparticles in Human Lung Cancer Cells
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2006.10.004
– volume: 519
  start-page: 250
  year: 2017
  ident: ref_44
  article-title: RGD Conjugated Liposome-Hollow Silica Hybrid Nanovehicles for Targeted and Controlled Delivery of Arsenic Trioxide against Hepatic Carcinoma
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2017.01.031
– volume: 16
  start-page: 422
  year: 2019
  ident: ref_5
  article-title: Thermo- and PH-Responsive, Lipid-Coated, Mesoporous Silica Nanoparticle-Based Dual Drug Delivery System To Improve the Antitumor Effect of Hydrophobic Drugs
  publication-title: Mol. Pharm.
  doi: 10.1021/acs.molpharmaceut.8b01073
– volume: 21
  start-page: 102041
  year: 2019
  ident: ref_86
  article-title: Time- and Dose-Dependent Gene Expression Analysis of Macrophage Response as a Function of Porosity of Silica Nanoparticles
  publication-title: Nanomed. Nanotechnol. Biol. Med.
  doi: 10.1016/j.nano.2019.102041
– volume: 311
  start-page: 622
  year: 2006
  ident: ref_75
  article-title: Toxic Potential of Materials at the Nanolevel
  publication-title: Science
  doi: 10.1126/science.1114397
– volume: 289
  start-page: L696
  year: 2005
  ident: ref_73
  article-title: Smaller Is Not Always Better: Nanotechnology Yields Nanotoxicology
  publication-title: Am. J. Physiol.-Lung Cell. Mol. Physiol.
  doi: 10.1152/ajplung.00277.2005
– volume: 116
  start-page: 111239
  year: 2020
  ident: ref_23
  article-title: Tumor Targeted Delivery of Umbelliferone via a Smart Mesoporous Silica Nanoparticles Controlled-Release Drug Delivery System for Increased Anticancer Efficiency
  publication-title: Mater. Sci. Eng. C
  doi: 10.1016/j.msec.2020.111239
– volume: 33
  start-page: 275
  year: 2016
  ident: ref_34
  article-title: Decidua-Derived Mesenchymal Stem Cells as Carriers of Mesoporous Silica Nanoparticles. In Vitro and in Vivo Evaluation on Mammary Tumors
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2016.01.017
– ident: ref_94
  doi: 10.3390/pharmaceutics12060487
– volume: 9
  start-page: 29
  year: 2011
  ident: ref_106
  article-title: Activation of Stress-Related Signalling Pathway in Human Cells upon SiO2 Nanoparticles Exposure as an Early Indicator of Cytotoxicity
  publication-title: J. Nanobiotechnol.
  doi: 10.1186/1477-3155-9-29
– volume: 537
  start-page: 148
  year: 2018
  ident: ref_55
  article-title: Loading of Polymyxin B onto Anionic Mesoporous Silica Nanoparticles Retains Antibacterial Activity and Enhances Biocompatibility
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2017.12.039
– ident: ref_83
  doi: 10.1371/journal.pone.0231634
– volume: 370
  start-page: 751
  year: 2019
  ident: ref_15
  article-title: Transient Receptor Potential Ion Channel–Dependent Toxicity of Silica Nanoparticles and Poly(Amido Amine) Dendrimers
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.118.253682
– volume: Volume 697
  start-page: 9
  year: 2011
  ident: ref_11
  article-title: Challenges for Nanoparticle Characterization
  publication-title: Characterization of Nanoparticles Intended for Drug Delivery
  doi: 10.1007/978-1-60327-198-1_2
– volume: 10
  start-page: 25994
  year: 2018
  ident: ref_61
  article-title: Nanosizing Noncrystalline and Porous Silica Material—Naturally Occurring Opal Shale for Systemic Tumor Targeting Drug Delivery
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.8b06275
– volume: 44
  start-page: 238
  year: 2019
  ident: ref_4
  article-title: In Vitro Toxicity Evaluation of Lomefloxacin-Loaded MCM-41 Mesoporous Silica Nanoparticles
  publication-title: Drug Chem. Toxicol.
  doi: 10.1080/01480545.2019.1571503
– volume: 9
  start-page: 21673
  year: 2017
  ident: ref_49
  article-title: Dacarbazine-Loaded Hollow Mesoporous Silica Nanoparticles Grafted with Folic Acid for Enhancing Antimetastatic Melanoma Response
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b05278
– volume: 5
  start-page: 8387
  year: 2013
  ident: ref_123
  article-title: Influence of Protein Corona on the Transport of Molecules into Cells by Mesoporous Silica Nanoparticles
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/am4014693
– volume: 5
  start-page: 248
  year: 2014
  ident: ref_97
  article-title: Size and Cell Type Dependent Uptake of Silica Nanoparticles
  publication-title: J. Nanomed. Nanotechnol.
– volume: 128
  start-page: 14792
  year: 2006
  ident: ref_95
  article-title: Effect of Surface Functionalization of MCM-41-Type Mesoporous Silica Nanoparticles on the Endocytosis by Human Cancer Cells
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja0645943
– volume: 14
  start-page: 1489
  year: 2019
  ident: ref_2
  article-title: Mesoporous Silica Nanoparticles as a Delivery System for Improving Antiangiogenic Therapy
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S195504
– ident: ref_124
  doi: 10.3390/pharmaceutics14010056
– volume: 3
  start-page: 4306
  year: 2018
  ident: ref_1
  article-title: Multiple-Responsive Mesoporous Silica Nanoparticles for Highly Accurate Drugs Delivery to Tumor Cells
  publication-title: ACS Omega
  doi: 10.1021/acsomega.8b00427
– volume: 179
  start-page: 352
  year: 2019
  ident: ref_20
  article-title: A Facile Strategy to Fabricate a PH-Responsive Mesoporous Silica Nanoparticle End-Capped with Amphiphilic Peptides by Self-Assembly
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2019.03.019
– ident: ref_25
  doi: 10.3390/pharmaceutics13020184
– volume: 52
  start-page: 214
  year: 2018
  ident: ref_60
  article-title: Comparison of Different Cytotoxicity Assays for in Vitro Evaluation of Mesoporous Silica Nanoparticles
  publication-title: Toxicol. Vitr.
  doi: 10.1016/j.tiv.2018.06.019
– volume: 7
  start-page: 36
  year: 2020
  ident: ref_9
  article-title: Mesoporous Silica Nanoparticles for Bio-Applications
  publication-title: Front. Mater.
  doi: 10.3389/fmats.2020.00036
– volume: 12
  start-page: 6239
  year: 2017
  ident: ref_52
  article-title: EpCAM Aptamer-Functionalized Polydopamine-Coated Mesoporous Silica Nanoparticles Loaded with DM1 for Targeted Therapy in Colorectal Cancer
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S143293
– volume: 192
  start-page: 45
  year: 2021
  ident: ref_115
  article-title: P53 Regulates Lipid Metabolism in Cancer
  publication-title: Int. J. Biol. Macromol.
  doi: 10.1016/j.ijbiomac.2021.09.188
– volume: 4
  start-page: 2322
  year: 2016
  ident: ref_35
  article-title: The Potential of Peptide Dendron Functionalized and Gadolinium Loaded Mesoporous Silica Nanoparticles as Magnetic Resonance Imaging Contrast Agents
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C5TB02709H
– volume: 113
  start-page: 823
  year: 2005
  ident: ref_74
  article-title: Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.7339
– volume: 8
  start-page: 165
  year: 2018
  ident: ref_91
  article-title: Mesoporous Silica Nanoparticles for Drug and Gene Delivery
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2018.01.007
– volume: 7
  start-page: 30
  year: 2013
  ident: ref_70
  article-title: In Vitro Cytotoxicity of Silver Nanoparticles on Osteoblasts and Osteoclasts at Antibacterial Concentrations
  publication-title: Nanotoxicology
  doi: 10.3109/17435390.2011.626538
– volume: 6
  start-page: 1700012
  year: 2017
  ident: ref_48
  article-title: Dendritic Mesoporous Silica Nanoparticles for PH-Stimuli-Responsive Drug Delivery of TNF-Alpha
  publication-title: Adv. Healthc. Mater.
  doi: 10.1002/adhm.201700012
– volume: 14
  start-page: 390
  year: 2019
  ident: ref_32
  article-title: An Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
  publication-title: Nanoscale Res. Lett.
  doi: 10.1186/s11671-019-3208-3
– volume: 110
  start-page: 217
  year: 2021
  ident: ref_19
  article-title: A Comparison of Chitosan, Mesoporous Silica and Poly(Lactic-Co-Glycolic) Acid Nanocarriers for Optimising Intestinal Uptake of Oral Protein Therapeutics
  publication-title: J. Pharm. Sci.
  doi: 10.1016/j.xphs.2020.09.026
– volume: 9
  start-page: 9470
  year: 2017
  ident: ref_46
  article-title: Bifunctional Succinylated ε-Polylysine-Coated Mesoporous Silica Nanoparticles for PH-Responsive and Intracellular Drug Delivery Targeting the Colon
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b00411
– volume: 76
  start-page: 7208
  year: 2016
  ident: ref_38
  article-title: A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-16-1681
– volume: 11
  start-page: 898
  year: 2020
  ident: ref_22
  article-title: Preparation of RGD Peptide/Folate Acid Double-Targeted Mesoporous Silica Nanoparticles and Its Application in Human Breast Cancer MCF-7 Cells
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00898
– volume: 30
  start-page: 101770
  year: 2020
  ident: ref_26
  article-title: Investigation of the Emission Spectra and Cytotoxicity of TiO2 and Ti-MSN/PpIX Nanoparticles to Induce Photodynamic Effects Using X-Ray
  publication-title: Photodiagnosis Photodyn. Ther.
  doi: 10.1016/j.pdpdt.2020.101770
– volume: 10
  start-page: 21927
  year: 2018
  ident: ref_59
  article-title: Self-Regulated Carboxyphenylboronic Acid-Modified Mesoporous Silica Nanoparticles with “Touch Switch” Releasing Property for Insulin Delivery
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.8b06998
– ident: ref_89
  doi: 10.3390/nano8121028
– volume: 9
  start-page: 2093
  year: 2017
  ident: ref_43
  article-title: Multifunctional Peptide-Amphiphile End-Capped Mesoporous Silica Nanoparticles for Tumor Targeting Drug Delivery
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.6b12647
– volume: 24
  start-page: 223
  year: 2019
  ident: ref_31
  article-title: The Interaction between SBA-15 Derivative Loaded with Ph3Sn(CH2)6OH and Human Melanoma A375 Cell Line: Uptake and Stem Phenotype Loss
  publication-title: JBIC J. Biol. Inorg. Chem.
  doi: 10.1007/s00775-019-01640-x
– volume: 6
  start-page: 245
  year: 2019
  ident: ref_14
  article-title: Cellular Toxicity of Mesoporous Silica Nanoparticle in SHSY5Y and BMMNCs Cell
  publication-title: Pharm. Nanotechnol.
  doi: 10.2174/2211738506666181031160108
– volume: 9
  start-page: 99
  year: 2017
  ident: ref_41
  article-title: Large Photoacoustic Effect Enhancement for ICG Confined inside MCM-41 Mesoporous Silica Nanoparticles
  publication-title: Nanoscale
  doi: 10.1039/C6NR08282C
– volume: 7
  start-page: 3067
  year: 2015
  ident: ref_103
  article-title: Conjugated Polymer and Drug Co-Encapsulated Nanoparticles for Chemo- and Photo-Thermal Combination Therapy with Two-Photon Regulated Fast Drug Release
  publication-title: Nanoscale
  doi: 10.1039/C4NR06420H
– volume: 103
  start-page: 976
  year: 2006
  ident: ref_118
  article-title: Analysis of P53 Mutations and Their Expression in 56 Colorectal Cancer Cell Lines
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0510146103
– volume: 34
  start-page: 559
  year: 2009
  ident: ref_113
  article-title: Exposure to Nanoparticles Is Related to Pleural Effusion, Pulmonary Fibrosis and Granuloma
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00178308
– volume: 83
  start-page: 28
  year: 2016
  ident: ref_33
  article-title: EpCAM Aptamer-Functionalized Mesoporous Silica Nanoparticles for Efficient Colon Cancer Cell-Targeted Drug Delivery
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/j.ejps.2015.12.014
– volume: 96
  start-page: 123
  year: 2019
  ident: ref_21
  article-title: An Injectable and Tumor-Specific Responsive Hydrogel with Tissue-Adhesive and Nanomedicine-Releasing Abilities for Precise Locoregional Chemotherapy
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2019.06.033
– volume: 7
  start-page: e2015
  year: 2016
  ident: ref_119
  article-title: P53 Functional Abnormality in Mesenchymal Stem Cells Promotes Osteosarcoma Development
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2015.367
– volume: 88
  start-page: 5413
  year: 1991
  ident: ref_96
  article-title: P53 Mutations in Human Lymphoid Malignancies: Association with Burkitt Lymphoma and Chronic Lymphocytic Leukemia
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.88.12.5413
– volume: 25
  start-page: 1925
  year: 2014
  ident: ref_104
  article-title: FITC-Conjugated Cyclic RGD Peptides as Fluorescent Probes for Staining Integrin Avβ3/Avβ5 in Tumor Tissues
  publication-title: Bioconjug. Chem.
  doi: 10.1021/bc500452y
– volume: 33
  start-page: 229
  year: 2013
  ident: ref_92
  article-title: Mesoporous Silica Nanoparticles in Nanotechnology
  publication-title: Crit. Rev. Biotechnol.
  doi: 10.3109/07388551.2012.685860
– volume: 11
  start-page: 1721
  year: 2015
  ident: ref_100
  article-title: Ultrasmall integrin-targeted silica nanoparticles modulate signaling events and cellular processes in a concentration-dependent manner
  publication-title: Small
  doi: 10.1002/smll.201402331
– volume: 9
  start-page: 22235
  year: 2017
  ident: ref_50
  article-title: Molecular Elucidation of Biological Response to Mesoporous Silica Nanoparticles in Vitro and in Vivo
  publication-title: ACS Appl. Mater. Interfaces
  doi: 10.1021/acsami.7b05359
– volume: 13
  start-page: 5849
  year: 2018
  ident: ref_62
  article-title: Antibacterial and Biodegradable Tissue Nano-Adhesives for Rapid Wound Closure
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S177109
– volume: 5
  start-page: 846
  year: 2009
  ident: ref_68
  article-title: Size-Dependent Cytotoxicity of Monodisperse Silica Nanoparticles in Human Endothelial Cells
  publication-title: Small
  doi: 10.1002/smll.200800461
– volume: 409
  start-page: 124502
  year: 2021
  ident: ref_24
  article-title: Subacute Toxicity of Mesoporous Silica Nanoparticles to the Intestinal Tract and the Underlying Mechanism
  publication-title: J. Hazard. Mater.
  doi: 10.1016/j.jhazmat.2020.124502
– volume: 65
  start-page: 393
  year: 2018
  ident: ref_53
  article-title: Lectin-Conjugated PH-Responsive Mesoporous Silica Nanoparticles for Targeted Bone Cancer Treatment
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2017.11.007
– volume: 37
  start-page: 113
  year: 2016
  ident: ref_39
  article-title: The Applicability of Conventional Cytotoxicity Assays to Predict Safety/Toxicity of Mesoporous Silica Nanoparticles, Silver and Gold Nanoparticles and Multi-Walled Carbon Nanotubes
  publication-title: Toxicol. Vitr.
  doi: 10.1016/j.tiv.2016.09.012
– volume: 501
  start-page: 112
  year: 2016
  ident: ref_101
  article-title: Synthesis of a Bi-Functional Dendrimer-Based Nanovehicle Co-Modified with RGDyC and TAT Peptides for Neovascular Targeting and Penetration
  publication-title: Int. J. Pharm.
  doi: 10.1016/j.ijpharm.2016.01.068
– volume: 65
  start-page: 199
  year: 2010
  ident: ref_67
  article-title: Size-Dependent Cytotoxic Effects of Amorphous Silica Nanoparticles on Langerhans Cells
  publication-title: Pharmazie
– volume: 4
  start-page: 5980
  year: 2016
  ident: ref_37
  article-title: Tailored Mesoporous Silica Nanosystem with Enhanced Permeability of the Blood–Brain Barrier to Antagonize Glioblastoma
  publication-title: J. Mater. Chem. B
  doi: 10.1039/C6TB01329E
– volume: 12
  start-page: 2172
  year: 2016
  ident: ref_47
  article-title: Mucin-1-Antibody-Conjugated Mesoporous Silica Nanoparticles for Selective Breast Cancer Detection in a Mucin-1 Transgenic Murine Mouse Model
  publication-title: J. Biomed. Nanotechnol.
  doi: 10.1166/jbn.2016.2318
– volume: 12
  start-page: 4991
  year: 2017
  ident: ref_13
  article-title: Physicochemical Characterization of Drug Nanocarriers
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S133832
– volume: 7
  start-page: 5577
  year: 2012
  ident: ref_78
  article-title: The Role of Surface Charge in Cellular Uptake and Cytotoxicity of Medical Nanoparticles
  publication-title: Int. J. Nanomed.
– volume: 124
  start-page: 138
  year: 2011
  ident: ref_72
  article-title: Bioavailability, Intracellular Mobilization of Nickel, and HIF-1α Activation in Human Lung Epithelial Cells Exposed to Metallic Nickel and Nickel Oxide Nanoparticles
  publication-title: Toxicol. Sci. J. Soc. Toxicol.
  doi: 10.1093/toxsci/kfr206
– volume: 15
  start-page: 241
  year: 2012
  ident: ref_17
  article-title: Power Study of Anova versus Kruskal-Wallis Test
  publication-title: J. Stat. Manag. Syst.
– volume: 109
  start-page: 722
  year: 1997
  ident: ref_114
  article-title: Role of P53 in UVB-Induced Apoptosis in Human HaCaT Keratinocytes
  publication-title: J. Investig. Dermatol.
  doi: 10.1111/1523-1747.ep12340708
– volume: 188
  start-page: 110824
  year: 2020
  ident: ref_28
  article-title: Synthesis of Lactoferrin Mesoporous Silica Nanoparticles for Pemetrexed/Ellagic Acid Synergistic Breast Cancer Therapy
  publication-title: Colloids Surf. B Biointerfaces
  doi: 10.1016/j.colsurfb.2020.110824
– volume: 15
  start-page: 9089
  year: 2020
  ident: ref_65
  article-title: The Size-dependent Cytotoxicity of Amorphous Silica Nanoparticles: A Systematic Review of in vitro Studies
  publication-title: Int. J. Nanomed.
  doi: 10.2147/IJN.S276105
– ident: ref_6
  doi: 10.3390/ma11081310
– ident: ref_18
– ident: ref_30
  doi: 10.3390/polym10040390
– volume: 16
  start-page: 1217
  year: 2002
  ident: ref_93
  article-title: Rapid Endo-Lysosomal Escape of Poly(DL-Lactide-Coglycolide) Nanoparticles: Implications for Drug and Gene Delivery
  publication-title: FASEB J.
  doi: 10.1096/fj.02-0088com
– volume: Volume 697
  start-page: 63
  year: 2011
  ident: ref_12
  article-title: Zeta Potential Measurement
  publication-title: Characterization of Nanoparticles Intended for Drug Delivery
  doi: 10.1007/978-1-60327-198-1_6
– volume: 5
  start-page: 1366
  year: 2011
  ident: ref_80
  article-title: Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects
  publication-title: ACS Nano
  doi: 10.1021/nn103077k
– volume: 45
  start-page: 1487
  year: 2019
  ident: ref_29
  article-title: Combined Chemo/Photothermal Therapy Based on Mesoporous Silica-Au Core-Shell Nanoparticles for Hepatocellular Carcinoma Treatment
  publication-title: Drug Dev. Ind. Pharm.
  doi: 10.1080/03639045.2019.1629688
– volume: 30
  start-page: 355
  year: 2015
  ident: ref_81
  article-title: Comparative Safety Evaluation of Silica-Based Particles
  publication-title: Toxicol. Vitr.
  doi: 10.1016/j.tiv.2015.09.030
– volume: 18
  start-page: 7016
  year: 1999
  ident: ref_117
  article-title: Induction of Apoptosis in U937 Human Leukemia Cells by Suberoylanilide Hydroxamic Acid (SAHA) Proceeds through Pathways That Are Regulated by Bcl-2/Bcl-XL, c-Jun, and P21CIP1, but Independent of P53
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1203176
– volume: 8
  start-page: 170
  year: 2020
  ident: ref_27
  article-title: Efficient Delivery of Triptolide Plus a MiR-30-5p Inhibitor Through the Use of Near Infrared Laser Responsive or CADY Modified MSNs for Efficacy in Rheumatoid Arthritis Therapeutics
  publication-title: Front. Bioeng. Biotechnol.
  doi: 10.3389/fbioe.2020.00170
– volume: 35
  start-page: 1977
  year: 2016
  ident: ref_102
  article-title: The Thyroid Hormone-Avβ3 Integrin Axis in Ovarian Cancer: Regulation of Gene Transcription and MAPK-Dependent Proliferation
  publication-title: Oncogene
  doi: 10.1038/onc.2015.262
– volume: 74
  start-page: 397
  year: 2018
  ident: ref_57
  article-title: Targeted and Controlled Drug Delivery by Multifunctional Mesoporous Silica Nanoparticles with Internal Fluorescent Conjugates and External Polydopamine and Graphene Oxide Layers
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2018.05.022
– volume: 91
  start-page: 6088
  year: 2019
  ident: ref_3
  article-title: Ratiometric Fluorescent Quantification of the Size-Dependent Cellular Toxicity of Silica Nanoparticles
  publication-title: Anal. Chem.
  doi: 10.1021/acs.analchem.9b00633
– volume: 17
  start-page: 1573
  year: 2007
  ident: ref_77
  article-title: Cytotoxic Effects of Nanoparticles Assessed in Vitro and in Vivo
  publication-title: J. Microbiol. Biotechnol.
– volume: 37
  start-page: 1
  year: 2013
  ident: ref_111
  article-title: High Passage Numbers Induce Resistance to Apoptosis in C2C12 Muscle Cells
  publication-title: Biocell. J. Soc. Latinoam. Microsc. Electron. Al
– volume: 46
  start-page: 921
  year: 2018
  ident: ref_58
  article-title: Curcumin-Loaded Redox-Responsive Mesoporous Silica Nanoparticles for Targeted Breast Cancer Therapy
  publication-title: Artif. Cells Nanomed. Biotechnol.
  doi: 10.1080/21691401.2018.1473412
– volume: 25
  start-page: 1343
  year: 2011
  ident: ref_66
  article-title: Size-Dependent Cytotoxicity of Amorphous Silica Nanoparticles in Human Hepatoma HepG2 Cells
  publication-title: Toxicol. Vitr. Int. J. Publ. Assoc. BIBRA
  doi: 10.1016/j.tiv.2011.05.003
– volume: 37
  start-page: 865
  year: 2016
  ident: ref_120
  article-title: TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.23035
– volume: 23
  start-page: 697
  year: 2009
  ident: ref_84
  article-title: Mesoporous Silica Nanoparticles Enhance MTT Formazan Exocytosis in HeLa Cells and Astrocytes
  publication-title: Toxicol. Vitr.
  doi: 10.1016/j.tiv.2009.02.007
SSID ssj0000913853
Score 2.3059704
Snippet Mesoporous Silica Nanoparticles (MSNs) have received increasing attention in biomedical applications due to their tuneable pore size, surface area, size,...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 2016
SubjectTerms Bioavailability
Biocompatibility
Biomedical materials
Cell viability
Cytotoxicity
Diameters
functionalisation
Investigations
mesoporous silica nanoparticles
Morphology
Nanomaterials
Nanoparticles
nanotoxicology
Outliers (statistics)
Parameters
Physicochemical properties
Pore size
Silica
Silicon dioxide
Statistical analysis
Surface charge
Surface chemistry
Surface stability
Thermal stability
Toxicity
Zeta potential
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Na90wDDelp_Yw9tFu2briQXcaoXHs-OO4lZZu0FLYCoUdgpUo7MFIyl4K638_Kcl75JWVXXaM7YMtWdZPsfyTEEcBFOgM8hSA4JvJtEkjtaQN2NoiFpjn_Br54tKeX5svN8XNrNQX54SN9MCj4I4NKA-A3tUuM1C52IBCbw19OItmYAIlnzcLpoYzOChNjmjMdNcU1x-3se0UndPk8OyGDxqo-v-GLx-mSc78ztlT8WQCjPLjONFnYgvb52J3RiP4Qnz_vKo0IrtGrooXyKvIiVfMnim7Vp7c913f_V5UBLslF-yosJZwLy9w2REG7-6W8uuC_-BJOnApkp4S5vbE9dnpt5PzdCqakFbG-T5VStcm-BCdQbJNvvgsYoaodOXQqUgW5zUSKAmmxgaMqitvK22AAkXmytP7YrvtWnwlJB0GMTAFfJOBAUMCx5oAEWkgrwNFzon4sBJjWU2M4lzY4mdJkQULvZwLPRHv16NvRyaNR8Z9Yo2sxzD_9dBAu6KcFl_-a1ck4mClz3IyymWZW0dLtF4ViXi37iZz4juS2CJJmsZ4lTHhT56Il6P61zPRhTMF4bNEuI2NsTHVzZ528WOg7A7MOqTC6_-xtjdiJ-c3GFxASR2I7f7XHb4lZNTD4WAEfwBQvg2u
  priority: 102
  providerName: Directory of Open Access Journals
Title Influence of Critical Parameters on Cytotoxicity Induced by Mesoporous Silica Nanoparticles
URI https://www.ncbi.nlm.nih.gov/pubmed/35745355
https://www.proquest.com/docview/2679796815
https://www.proquest.com/docview/2681034822
https://pubmed.ncbi.nlm.nih.gov/PMC9228019
https://doaj.org/article/4b18bbe87d704bc7afb1e86404b76e44
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwEB3R7QUOiG9SyspIcEJR48SJ7ROiVZeC1KoCKlXiEMXJpKyE4rabSvTfM5N1ll0EHGPPwfHY4zfj8RuA19ZJlyUujZ0j-KaSTMUVtcStK5oCMcc05dfIxyfF0Zn6dJ6fh4DbIqRVjjZxMNSNrzlGvpcW2mpbGJm_u7yKuWoU366GEhpbsE0m2JgJbO8fnpx-XkVZmPWSDqRlxntG_v1eV3VekjAdfMXGWTRQ9v8NZ_6ZLrl2_swewP0AHMX7paYfwh3sHsG9NTrBx_Dt41hxRPhWjEUMxGnFCVjMoil8Jw5ue9_7n_Oa4Lfgwh01NsLdimNceMLi_mYhvsw5kifI8JJHHRLnnsDZ7PDrwVEciifEtdKmj6XMGmWNrbRC2qN8AZpXCaLMao1aVrTzTIYETqxqsHVKNrUp6kw5chiZMy97CpPOd_gcBBmFyjIVfJs45ZRyGhsCRlXr0saSBx3B23Eayzowi3OBix8leRg86eX6pEfwZiV9uWTU-IfcPmtkJcM82EODv74ow8-XyknjHBrd6ES5WtOYJJpC0YcuUKkIdkd9lmFzLsrfSymCV6tu2lZ8V1J1SDNNMkYmTPyTRvBsqf7VSLJcq5xwWgR6Y2FsDHWzp5t_H6i7LbMPSbvz_2G9gLspv7LgEklyFyb99Q2-JOzTuylsmdmHaVjm0yGC8AvEEQgZ
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VcgAOiDeBAkaiJxQ1Tpw4PiAEhWWXdiskWqkShzROJrASiks3Feyf4jcyk8eyi4Bbj4mtyBmP52GPvw_gmbHSRoENfWspfFNBpPyc3viVTcoEMcYw5NvI04NkfKTeH8fHG_BzuAvDZZWDTWwNdekK3iPfCRNttElSGb88_eYzaxSfrg4UGp1a7OHiO6Vs8xeTNzS_22E4enu4O_Z7VgG_UDptfCmjUpnU5FohKS-fDMZ5gCijQqOWOalkGiF5baNKrKySZZEmRaQsZVIMJhfRdy_BZRWRJ-eb6aN3yz0dxtgk99fV11N7sFPntZPkHcjNJmueryUI-FtU-2dx5oq3G92A632YKl51enUTNrC-BddWwAtvw6fJwG8iXCUGygTxIedyL8bsFK4Wu4vGNe7HrKBgXzBNSIGlsAsxxbmjyN-dz8XHGe8bCjLzlL_3ZXp34OhChHoXNmtX430QZIJyw8DzVWCVVcpqLCkMyysblobydQ-eD2LMih7HnOk0vmaUz7DQs1Whe7C97H3a4Xf8o99rnpFlH0bdbl-4s89Z__OZsjK1FlNd6kDZQtOYJKaJogedoFIebA3zmfWmYJ79VlwPni6baRHzyUxeI0ma-qQyYJih0IN73fQvRxLFWsUUFXqg1xRjbajrLfXsSwsUbhjrSJoH_x_WE7gyPpzuZ_uTg72HcDXk-x1MziS3YLM5O8dHFHU19nGr6gJOLnpt_QIwST-Q
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrYTggHgTKGAkekLRxrETxweE6GPVpXS1AipV4hDixGlXQnHppoL9a_w6ZjYPdhFw6zGOFTnj8Tzs8fcBvNSGGxGY0DcGwzcZCOln2OKXJi5iayMbhnQb-WgSHxzLdyfRyQb87O7CUFllZxOXhrpwOe2RD8NYaaXjhEfDsi2LmO6N3px_84lBik5aOzqNRkUO7eI7pm_z1-M9nOvtMBztf9o98FuGAT-XKql9zkUhdaIzJS0qMp0SRllgLRe5sopnqJ6JsOjBtSxsaSQv8iTOhTSYVRGwnMDvXoNNRVnRADZ39ifTD_0ODyFuojNsqu2F0MGwyirH0Veg043X_OCSLuBvMe6fpZorvm90G261QSt722jZHdiw1V24uQJleA8-jzu2E-ZK1hEosGlGxV-E4MlcxXYXtavdj1mOoT8j0pDcFsws2JGdO8wD3OWcfZzRLiJDo4_ZfFu0dx-Or0SsD2BQuco-AoYGKdMEQ18GRhopjbIFBmVZacJCY_buwatOjGneopoTucbXFLMbEnq6KnQPtvve5w2axz_67dCM9H0Ig3vZ4C5O0_bnU2l4YoxNVKECaXKFY-I2iSU-qNhK6cFWN59paxjm6W819uBF_xqXNJ3TZJVFSWOfhAcEOhR68LCZ_n4kIlIywhjRA7WmGGtDXX9Tzc6WsOGakI-4fvz_YT2H67iu0vfjyeETuBHSZQ9iauJbMKgvLu1TDMFq86zVdQZfrnp5_QJYgUUi
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Influence+of+Critical+Parameters+on+Cytotoxicity+Induced+by+Mesoporous+Silica+Nanoparticles&rft.jtitle=Nanomaterials+%28Basel%2C+Switzerland%29&rft.au=Ahmadi%2C+Amirsadra&rft.au=Sokunbi%2C+Moses&rft.au=Patel%2C+Trisha&rft.au=Chang%2C+Ming-Wei&rft.date=2022-06-11&rft.issn=2079-4991&rft.eissn=2079-4991&rft.volume=12&rft.issue=12&rft_id=info:doi/10.3390%2Fnano12122016&rft_id=info%3Apmid%2F35745355&rft.externalDocID=35745355
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2079-4991&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2079-4991&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2079-4991&client=summon