Genetic polymorphisms of interleukin‐1‐beta in association with sustained response to anti‐viral treatment in chronic hepatitis B in Chinese

• Published in: Alimentary pharmacology & therapeutics Vol. 23; no. 12; pp. 1703 - 1711
• Main Authors: CHAN, H. L.‐Y., TSE, A. M.‐L., ZHANG, M.‐D., WONG, V. W.‐S., CHIM, A. M.‐L., HUI, A. Y., SUNG, J. J.‐Y.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2006; Blackwell
• Subjects: Adult; Antiviral Agents - therapeutic use; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Digestive system; Female; Gastroenterology. Liver. Pancreas. Abdomen; Hepatitis B virus; Hepatitis B, Chronic - drug therapy; Hepatitis B, Chronic - genetics; Human viral diseases; Humans; Infectious diseases; Interferon-alpha - therapeutic use; Interleukin-1 - genetics; Lamivudine - therapeutic use; Male; Medical sciences; Pharmacology. Drug treatments; Polyethylene Glycols - therapeutic use; Polymorphism, Genetic - genetics; Recombinant Proteins; Treatment Outcome; Viral diseases; Viral hepatitis; Asia; China; Genetic variability; Cytokine; Hepatic disease; Genotype; Interleukin 1β; Infection; Viral hepatitis B; Virus; Association; Treatment; Viral disease; Digestive diseases; Chinese

Summary Background Interleukin‐1β is a pro‐inflammatory cytokine that may influence host defence against viral infection. Aim To investigate the impact of interleukin‐1β gene polymorphism on the response to anti‐viral treatment. Method Hepatitis B e antigen‐positive chronic hepatitis B patients who...