Gender, race and diet affect platelet function tests in normal subjects, contributing to a high rate of abnormal results

• Published in: British journal of haematology Vol. 165; no. 6; pp. 842 - 853
• Main Authors: Miller, Connie H., Rice, Anne S., Garrett, Katherine, Stein, Sidney F.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.06.2014
• Subjects: Adult; Anti-Bacterial Agents - pharmacology; Biological and medical sciences; Blood Platelets - drug effects; Blood Platelets - physiology; Diet; Ethnicity; Female; flavonoids; Hematologic and hematopoietic diseases; Humans; Male; Medical sciences; platelet aggregation; Platelet Aggregation - drug effects; Platelet Aggregation - physiology; platelet function tests; Platelet Function Tests - methods; Platelet Function Tests - standards; platelets; Reference Values; Reproducibility of Results; ristocetin; Ristocetin - pharmacology; Sex Factors; Tumors; Human; Hematology; Nutrition; platelet function tests; Sex; Flavonoid; platelets; Feeding; platelet aggregation; Aggregation; Polyphenol; Platelet; Cancerology; Diet; Polypeptide; Hemostasis; Platelet function; Race; Phenols; flavonoids; Ristocetin; ristocetin

Summary To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet‐rich plasma (PRP) in the Bio/Data PAP‐4 Aggregometer (BD) and Chrono‐Log Lumi‐Ag...