Gender, race and diet affect platelet function tests in normal subjects, contributing to a high rate of abnormal results
Summary To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet‐rich plasma (PRP) in the Bio/Data PAP‐4 Aggregometer (BD) and Chrono‐Log Lumi‐Ag...
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| Published in | British journal of haematology Vol. 165; no. 6; pp. 842 - 853 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Blackwell
01.06.2014
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Summary
To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet‐rich plasma (PRP) in the Bio/Data PAP‐4 Aggregometer (BD) and Chrono‐Log Lumi‐Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL‐PRP and CL‐WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug‐free specimens with CL‐PRP, 15% with CL‐WB, 13% with BD‐PRP and 6% with MP‐WB, increasing with inclusion of REL to 28% for CL‐PRP and 30% for CL‐WB. Epinephrine AGG and REL were significantly reduced in males (P < 0·0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P < 0·0001). One‐third of specimens drawn following flavonoid‐rich food exposures had aberrant results, compared to 8·5% of specimens without such exposures (P = 0·0035). PRP tests had less intra‐individual variation than WB tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. |
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| AbstractList | To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using four methods: platelet aggregation (
AGG
) in platelet‐rich plasma (
PRP
) in the Bio/Data
PAP
‐4 Aggregometer (
BD
) and
C
hrono‐
L
og
L
umi‐
A
ggregometer (
CL
); and
AGG
in whole blood (
WB
) in the
CL
and
M
ultiplate
P
latelet
F
unction
A
nalyser (
MP
), with
ATP
release (
REL
) in
CL
‐
PRP
and
CL
‐
WB
. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one
AGG
abnormality was seen in 21% of 81 drug‐free specimens with
CL
‐
PRP
, 15% with
CL
‐
WB
, 13% with
BD
‐
PRP
and 6% with
MP
‐
WB
, increasing with inclusion of
REL
to 28% for
CL
‐
PRP
and 30% for
CL
‐
WB
. Epinephrine
AGG
and
REL
were significantly reduced in males (
P
<
0·0001). Ristocetin
AGG
and collagen and thrombin
REL
were significantly reduced in
B
lacks (
P
<
0·0001). One‐third of specimens drawn following flavonoid‐rich food exposures had aberrant results, compared to 8·5% of specimens without such exposures (
P
=
0·0035).
PRP
tests had less intra‐individual variation than
WB
tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug-free specimens with CL-PRP, 15% with CL-WB, 13% with BD-PRP and 6% with MP-WB, increasing with inclusion of REL to 28% for CL-PRP and 30% for CL-WB. Epinephrine AGG and REL were significantly reduced in males (P < 0·0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P < 0·0001). One-third of specimens drawn following flavonoid-rich food exposures had aberrant results, compared to 8·5% of specimens without such exposures (P = 0·0035). PRP tests had less intra-individual variation than WB tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug-free specimens with CL-PRP, 15% with CL-WB, 13% with BD-PRP and 6% with MP-WB, increasing with inclusion of REL to 28% for CL-PRP and 30% for CL-WB. Epinephrine AGG and REL were significantly reduced in males (P < 0·0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P < 0·0001). One-third of specimens drawn following flavonoid-rich food exposures had aberrant results, compared to 8·5% of specimens without such exposures (P = 0·0035). PRP tests had less intra-individual variation than WB tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients.To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug-free specimens with CL-PRP, 15% with CL-WB, 13% with BD-PRP and 6% with MP-WB, increasing with inclusion of REL to 28% for CL-PRP and 30% for CL-WB. Epinephrine AGG and REL were significantly reduced in males (P < 0·0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P < 0·0001). One-third of specimens drawn following flavonoid-rich food exposures had aberrant results, compared to 8·5% of specimens without such exposures (P = 0·0035). PRP tests had less intra-individual variation than WB tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug-free specimens with CL-PRP, 15% with CL-WB, 13% with BD-PRP and 6% with MP-WB, increasing with inclusion of REL to 28% for CL-PRP and 30% for CL-WB. Epinephrine AGG and REL were significantly reduced in males (P<0.0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P<0.0001). One-third of specimens drawn following flavonoid-rich food exposures had aberrant results, compared to 8.5% of specimens without such exposures (P =0.0035). PRP tests had less intra-individual variation than WB tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using 4 methods: platelet aggregation (AGG) in platelet-rich plasma (PRP) in the Bio/Data PAP-4 Aggregometer (BD) and Chrono-Log Lumi-Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyzer (MP), with ATP release (REL) in CL-PRP and CL-WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug-free specimens with CL-PRP, 15% with CL-WB, 13% with BD-PRP, and 6% with MP-WB, increasing with inclusion of REL to 28% for CL-PRP and 30% for CL-WB. Epinephrine AGG and REL were significantly reduced in males ( P <0.0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks ( P <0.0001). One-third of specimens drawn following flavonoid-rich food exposures had aberrant results, compared to 8.5% of specimens without such exposures ( P =0.0035). PRP tests had less intra-individual variation than WB tests. Gender, race, diet, and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. Summary To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using four methods: platelet aggregation (AGG) in platelet‐rich plasma (PRP) in the Bio/Data PAP‐4 Aggregometer (BD) and Chrono‐Log Lumi‐Aggregometer (CL); and AGG in whole blood (WB) in the CL and Multiplate Platelet Function Analyser (MP), with ATP release (REL) in CL‐PRP and CL‐WB. Food and medication exposures were recorded prospectively for 2 weeks prior to each blood draw. At least one AGG abnormality was seen in 21% of 81 drug‐free specimens with CL‐PRP, 15% with CL‐WB, 13% with BD‐PRP and 6% with MP‐WB, increasing with inclusion of REL to 28% for CL‐PRP and 30% for CL‐WB. Epinephrine AGG and REL were significantly reduced in males (P < 0·0001). Ristocetin AGG and collagen and thrombin REL were significantly reduced in Blacks (P < 0·0001). One‐third of specimens drawn following flavonoid‐rich food exposures had aberrant results, compared to 8·5% of specimens without such exposures (P = 0·0035). PRP tests had less intra‐individual variation than WB tests. Gender, race, diet and test system affected results of platelet function testing in healthy subjects, suggesting caution when interpreting the results of platelet function testing in patients. |
| Author | Miller, Connie H. Stein, Sidney F. Garrett, Katherine Rice, Anne S. |
| AuthorAffiliation | 2 Emory University School of Medicine, Atlanta, GA, USA 1 Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA |
| AuthorAffiliation_xml | – name: 1 Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA – name: 2 Emory University School of Medicine, Atlanta, GA, USA |
| Author_xml | – sequence: 1 givenname: Connie H. surname: Miller fullname: Miller, Connie H. organization: Centers for Disease Control and Prevention – sequence: 2 givenname: Anne S. surname: Rice fullname: Rice, Anne S. organization: Centers for Disease Control and Prevention – sequence: 3 givenname: Katherine surname: Garrett fullname: Garrett, Katherine organization: Emory University School of Medicine – sequence: 4 givenname: Sidney F. surname: Stein fullname: Stein, Sidney F. organization: Emory University School of Medicine |
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| Keywords | Human Hematology Nutrition platelet function tests Sex Flavonoid platelets Feeding platelet aggregation Aggregation Polyphenol Platelet Cancerology Diet Polypeptide Hemostasis Platelet function Race Phenols flavonoids Ristocetin ristocetin |
| Language | English |
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To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week... To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using... To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using... To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2-6 occasions at 2 week intervals using... To assess sources of variability in platelet function tests in normal subjects, 64 healthy young adults were tested on 2–6 occasions at 2 week intervals using... |
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| SubjectTerms | Adult Anti-Bacterial Agents - pharmacology Biological and medical sciences Blood Platelets - drug effects Blood Platelets - physiology Diet Ethnicity Female flavonoids Hematologic and hematopoietic diseases Humans Male Medical sciences platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - physiology platelet function tests Platelet Function Tests - methods Platelet Function Tests - standards platelets Reference Values Reproducibility of Results ristocetin Ristocetin - pharmacology Sex Factors Tumors |
| Title | Gender, race and diet affect platelet function tests in normal subjects, contributing to a high rate of abnormal results |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbjh.12827 https://www.ncbi.nlm.nih.gov/pubmed/24617520 https://www.proquest.com/docview/1532479678 https://www.proquest.com/docview/1753458319 https://pubmed.ncbi.nlm.nih.gov/PMC4477706 |
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