Interleukin-6 Induction of Protein S Is Regulated Through Signal Transducer and Activator of Transcription 3

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 26; no. 9; pp. 2168 - 2174
• Main Authors: de Wolf, Cornelia J.F, Cupers, Rosemiek M.J, Bertina, Rogier M, Vos, Hans L
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.09.2006; Hagerstown, MD Lippincott
• Subjects: Associated diseases and complications; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cell Line, Tumor; Diabetes. Impaired glucose tolerance; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Gene Expression Regulation; Humans; Interleukin-6 - pharmacology; Interleukin-6 - physiology; Medical sciences; Phosphorylation; Promoter Regions, Genetic; Protein S - biosynthesis; Protein S - genetics; Protein S - metabolism; Response Elements; RNA, Messenger - biosynthesis; STAT3 Transcription Factor - metabolism; STAT3 Transcription Factor - physiology; Vascular disease; Interleukin 6; C/EBPβ; PROS1; Cytokine; Atherosclerosis; STAT3; Cardiovascular disease; Protein S; Vitronectin; IL-6

OBJECTIVE—The protein C anticoagulant pathway is an essential process for attenuating thrombin generation by the membrane-bound procoagulant complexes tenase and prothrombinase. In this pathway, protein S (PS) serves as a cofactor for activated protein C. PS circulates in plasma both in a free form...