Prognostic factors in angioimmunoblastic lymphadenopathy

• Published in: Cancer Vol. 59; no. 2; pp. 208 - 212
• Main Authors: Archimbaud, Eric, Coiffier, Bertrand, Bryon, Paul A., Vasselon, Christian, Brizard, Charles P., Viala, Jean J.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 15.01.1987; Wiley-Liss
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Biological and medical sciences; Erythema - complications; Female; Hematologic and hematopoietic diseases; Humans; Immunoblastic Lymphadenopathy - complications; Immunoblastic Lymphadenopathy - physiopathology; L-Lactate Dehydrogenase - blood; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymph Nodes - pathology; Male; Medical sciences; Middle Aged; Prognosis; Prospective Studies; Sex Factors; Prognosis; Immunoblastic lymphadenopathy
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(19870115)59:2<208::AID-CNCR2820590205>3.0.CO;2-7

In order to identify prognostic factors in angioimmunoblastic lymphadenopathy (AIL), 30 directly diagnosed patients were prospectively followed for more than 42 months. Age and sex distribution, clinical and laboratory findings and evolution were not different from previously reported series. Median duration of survival was 24 months. Parameters associated with a longer survival in our series were localized adenopathies (P = 0.01) and the achievement of a remission (P < 0.0001). Features associated with a shorter survival included drug exposure in relation to the onset of the disease (P = 0.02), rash (P < 0.0001), lymph node eosinophilia (P = 0.03) and elevated serum lactic dehydrogenase (P = 0.03). Drug exposure and rash were, however, significantly dependent (P = 0.02). In addition, lymphopenia, the presence of circulating immune complexes, and the absence of polyclonal hypergammaglobulinemia may indicate a poor prognosis, although the significance level is not achieved in this short series. None of the parameters tested was significantly related to the lymphomatous transformation of AIL, which occurred in four cases. It is concluded that multicentric prospective studies of AIL are necessary in order to better define this disorder, to find prognostic factors, and to optimize therapy. Cancer 59:208–212, 1987.