Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ε4 gene dose in cognitively normal adults: A cross-validation study using voxel-based multi-modal partial least squares

• Published in: NeuroImage (Orlando, Fla.) Vol. 60; no. 4; pp. 2316 - 2322
• Main Authors: Chen, Kewei, Ayutyanont, Napatkamon, Langbaum, Jessica B.S., Fleisher, Adam S., Reschke, Cole, Lee, Wendy, Liu, Xiaofen, Alexander, Gene E., Bandy, Dan, Caselli, Richard J., Reiman, Eric M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2012; Elsevier Limited
• Subjects: Age; Algorithms; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Apolipoprotein E4 - genetics; Apolipoproteins; Brain - diagnostic imaging; Cardiovascular disease; Cognitive ability; Family medical history; Female; Fluorodeoxyglucose F18; Gender; Gene Dosage; Glucose - metabolism; Health risk assessment; Humans; Image Interpretation, Computer-Assisted; Least-Squares Analysis; Magnetic Resonance Imaging; Male; Medical imaging; Middle Aged; NMR; Nuclear magnetic resonance; Positron-Emission Tomography; Radiopharmaceuticals; Risk Factors; Studies

We previously introduced a voxel-based, multi-modal application of the partial least square algorithm (MMPLS) to characterize the linkage between patterns in a person's complementary complex datasets without the need to correct for multiple regional comparisons. Here we used it to demonstrate a...