Antibodies against oncoproteins E6 and E7 of human papillomavirus types 16 and 18 in patients with head‐and‐neck squamous‐cell carcinoma

• Published in: International journal of cancer Vol. 85; no. 6; pp. 815 - 818
• Main Authors: Zumbach, Klaus, Hoffmann, Markus, Kahn, Tomas, Bosch, Franz, Gottschlich, Stefan, Görögh, Tibor, Rudert, Heinrich, Pawlita, Michael
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 15.03.2000
• Subjects: Adult; AE6 protein; AE7 protein; Aged; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - virology; DNA, Viral - analysis; Enzyme-Linked Immunosorbent Assay; Female; Head and Neck Neoplasms - blood; Head and Neck Neoplasms - virology; head-and-neck squamous-cell carcinoma; Human papillomavirus 16; Human papillomavirus 18; Humans; Male; Middle Aged; Oncogene Proteins, Viral - blood; Oncogene Proteins, Viral - metabolism; Papillomaviridae - genetics; Papillomaviridae - metabolism

Human papillomaviruses (HPVs) have been recognized as an essential pathogenic factor in anogenital cancer. HPV DNA has also been found in a subgroup of head‐and‐neck squamous‐cell carcinomas (HNSCCs), and a causative role of the virus in the development of these tumors has been suggested by the conc...