Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model

• Published in: Annals of the New York Academy of Sciences Vol. 1397; no. 1; pp. 130 - 142
• Main Authors: Sturgeon, Craig, Lan, Jinggang, Fasano, Alessio
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2017
• Subjects: Animals; barrier function; Body Weight - drug effects; Cholera Toxin - antagonists & inhibitors; Cholera Toxin - genetics; Cholera Toxin - metabolism; Colitis; Colitis - chemically induced; Colitis - genetics; Colitis - physiopathology; Dextran; Dextran Sulfate; Drinking water; Duodenum; Environmental monitoring; Female; Gene expression; Histology; Impairment; inflammation; Inflammatory bowel disease; Inflammatory diseases; Intestinal Mucosa - metabolism; Intestinal Mucosa - physiopathology; intestinal permeability; Intestine; Intestine, Small - metabolism; Intestine, Small - physiopathology; Jejunum; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morbidity; Mortality; Oligopeptides - pharmacology; Pathogenesis; Permeability; Permeability - drug effects; Rodents; Sodium; Sodium sulfate; Sulfates; Tight junctions; Time Factors; Transgenic mice; Weight loss; zonulin; intestinal permeability; zonulin; tight junctions; inflammation; barrier function

Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the develop...