Nanoplatforms for Targeted Molecular Imaging in Living Subjects

Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform‐based molecular imaging has emerged as an interdisciplinary field, which involves chemistry, engineering, biology, and medicine. Possessing unpreced...

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Published in	Small (Weinheim an der Bergstrasse, Germany) Vol. 3; no. 11; pp. 1840 - 1854
Main Authors	Cai, Weibo, Chen, Xiaoyuan
Format	Journal Article
Language	English
Published	Weinheim WILEY-VCH Verlag 05.11.2007 WILEY‐VCH Verlag
Subjects	cancer Contrast Media Diagnostic Imaging - trends Drug Delivery Systems - methods Humans Image Enhancement - methods molecular imaging Molecular Probe Techniques - trends nanomedicine Nanomedicine - trends nanoplatforms Nanostructures nanotechnology
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Abstract	Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform‐based molecular imaging has emerged as an interdisciplinary field, which involves chemistry, engineering, biology, and medicine. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of diseases, nanoplatforms have been employed in every single biomedical imaging modality, namely, optical imaging, computed tomography, ultrasound, magnetic resonance imaging, single‐photon‐emission computed tomography, and positron emission tomography. Multifunctionality is the key advantage of nanoplatforms over traditional approaches. Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoplatform to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers. In this Review, we will summarize the current state‐of‐the‐art of nanoplatforms for targeted molecular imaging in living subjects. A view on imaging: Many nanoparticles and a variety of techniques have been used for targeted molecular imaging in living subjects. This Review article takes an overview of the various materials and techniques that are currently at the development stage, undergoing clinical trials, or are even in current usage. The image shows how tumors in mice can be highlighted with quantum dots using near‐infrared fluorescence imaging.
AbstractList	Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform-based molecular imaging has emerged as an interdisciplinary field, which involves chemistry, engineering, biology, and medicine. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of diseases, nanoplatforms have been employed in every single biomedical imaging modality, namely, optical imaging, computed tomography, ultrasound, magnetic resonance imaging, single-photon-emission computed tomography, and positron emission tomography. Multifunctionality is the key advantage of nanoplatforms over traditional approaches. Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoplatform to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers. In this Review, we will summarize the current state-of-the-art of nanoplatforms for targeted molecular imaging in living subjects. Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform-based molecular imaging has emerged as an interdisciplinary field, which involves chemistry, engineering, biology, and medicine. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of diseases, nanoplatforms have been employed in every single biomedical imaging modality, namely, optical imaging, computed tomography, ultrasound, magnetic resonance imaging, single-photon-emission computed tomography, and positron emission tomography. Multifunctionality is the key advantage of nanoplatforms over traditional approaches. Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoplatform to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers. In this Review, we will summarize the current state-of-the-art of nanoplatforms for targeted molecular imaging in living subjects.Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform-based molecular imaging has emerged as an interdisciplinary field, which involves chemistry, engineering, biology, and medicine. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of diseases, nanoplatforms have been employed in every single biomedical imaging modality, namely, optical imaging, computed tomography, ultrasound, magnetic resonance imaging, single-photon-emission computed tomography, and positron emission tomography. Multifunctionality is the key advantage of nanoplatforms over traditional approaches. Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoplatform to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers. In this Review, we will summarize the current state-of-the-art of nanoplatforms for targeted molecular imaging in living subjects. Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform‐based molecular imaging has emerged as an interdisciplinary field, which involves chemistry, engineering, biology, and medicine. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of diseases, nanoplatforms have been employed in every single biomedical imaging modality, namely, optical imaging, computed tomography, ultrasound, magnetic resonance imaging, single‐photon‐emission computed tomography, and positron emission tomography. Multifunctionality is the key advantage of nanoplatforms over traditional approaches. Targeting ligands, imaging labels, therapeutic drugs, and many other agents can all be integrated into the nanoplatform to allow for targeted molecular imaging and molecular therapy by encompassing many biological and biophysical barriers. In this Review, we will summarize the current state‐of‐the‐art of nanoplatforms for targeted molecular imaging in living subjects. A view on imaging: Many nanoparticles and a variety of techniques have been used for targeted molecular imaging in living subjects. This Review article takes an overview of the various materials and techniques that are currently at the development stage, undergoing clinical trials, or are even in current usage. The image shows how tumors in mice can be highlighted with quantum dots using near‐infrared fluorescence imaging.
Author	Cai, Weibo Chen, Xiaoyuan
Author_xml	– sequence: 1 givenname: Weibo surname: Cai fullname: Cai, Weibo organization: Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University, Stanford, CA 94305, USA, Fax: (+1) 650-736-7925 – sequence: 2 givenname: Xiaoyuan surname: Chen fullname: Chen, Xiaoyuan email: shawchen@stanford.edu organization: Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University, Stanford, CA 94305, USA, Fax: (+1) 650-736-7925
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/17943716$$D View this record in MEDLINE/PubMed
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Snippet	Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform‐based... Molecular or personalized medicine is the future of patient management and molecular imaging plays a key role towards this goal. Recently, nanoplatform-based...
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SubjectTerms	cancer Contrast Media Diagnostic Imaging - trends Drug Delivery Systems - methods Humans Image Enhancement - methods molecular imaging Molecular Probe Techniques - trends nanomedicine Nanomedicine - trends nanoplatforms Nanostructures nanotechnology
Title	Nanoplatforms for Targeted Molecular Imaging in Living Subjects
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