A comparative study of bone marrow and peripheral blood CD34+ myeloblasts in acute myeloid leukaemia
Summary To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+ myeloblasts of paired BM and PB samples from 14 AML patients in terms of surface phenotype, homing and engraftment in a xenogeneic transplan...
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Published in | British journal of haematology Vol. 144; no. 4; pp. 484 - 491 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.02.2009
Blackwell |
Subjects | |
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To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+ myeloblasts of paired BM and PB samples from 14 AML patients in terms of surface phenotype, homing and engraftment in a xenogeneic transplantation model, and gene expression, based on microarray studies and quantitative polymerase chain reaction. While there was no significant difference in surface phenotypes between these two populations, in vivo assay showed significantly better homing potential of PB CD34+ cells than BM CD34+ cells. Significant correlation between homing and engraftment in AML samples was also noted. In addition, gene expression profiling of CD34+ cells from five paired BM and PB leukaemic samples showed that genes involved in G‐protein and prostaglandin signalling, chemotaxis and stress response, cell proliferation and apoptosis were down‐regulated in PB CD34+ myeloblasts. These data suggested that circulating primitive myeloblasts in AML are functionally different from those residing in the marrow compartment, and such differences may be partly regulated by the BM microenvironment. |
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AbstractList | SummaryTo examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+ myeloblasts of paired BM and PB samples from 14 AML patients in terms of surface phenotype, homing and engraftment in a xenogeneic transplantation model, and gene expression, based on microarray studies and quantitative polymerase chain reaction. While there was no significant difference in surface phenotypes between these two populations, in vivo assay showed significantly better homing potential of PB CD34+ cells than BM CD34+ cells. Significant correlation between homing and engraftment in AML samples was also noted. In addition, gene expression profiling of CD34+ cells from five paired BM and PB leukaemic samples showed that genes involved in G-protein and prostaglandin signalling, chemotaxis and stress response, cell proliferation and apoptosis were down-regulated in PB CD34+ myeloblasts. These data suggested that circulating primitive myeloblasts in AML are functionally different from those residing in the marrow compartment, and such differences may be partly regulated by the BM microenvironment. To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34(+) myeloblasts of paired BM and PB samples from 14 AML patients in terms of surface phenotype, homing and engraftment in a xenogeneic transplantation model, and gene expression, based on microarray studies and quantitative polymerase chain reaction. While there was no significant difference in surface phenotypes between these two populations, in vivo assay showed significantly better homing potential of PB CD34(+) cells than BM CD34(+) cells. Significant correlation between homing and engraftment in AML samples was also noted. In addition, gene expression profiling of CD34(+) cells from five paired BM and PB leukaemic samples showed that genes involved in G-protein and prostaglandin signalling, chemotaxis and stress response, cell proliferation and apoptosis were down-regulated in PB CD34(+) myeloblasts. These data suggested that circulating primitive myeloblasts in AML are functionally different from those residing in the marrow compartment, and such differences may be partly regulated by the BM microenvironment. Summary To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+ myeloblasts of paired BM and PB samples from 14 AML patients in terms of surface phenotype, homing and engraftment in a xenogeneic transplantation model, and gene expression, based on microarray studies and quantitative polymerase chain reaction. While there was no significant difference in surface phenotypes between these two populations, in vivo assay showed significantly better homing potential of PB CD34+ cells than BM CD34+ cells. Significant correlation between homing and engraftment in AML samples was also noted. In addition, gene expression profiling of CD34+ cells from five paired BM and PB leukaemic samples showed that genes involved in G‐protein and prostaglandin signalling, chemotaxis and stress response, cell proliferation and apoptosis were down‐regulated in PB CD34+ myeloblasts. These data suggested that circulating primitive myeloblasts in AML are functionally different from those residing in the marrow compartment, and such differences may be partly regulated by the BM microenvironment. Summary To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34 + myeloblasts of paired BM and PB samples from 14 AML patients in terms of surface phenotype, homing and engraftment in a xenogeneic transplantation model, and gene expression, based on microarray studies and quantitative polymerase chain reaction. While there was no significant difference in surface phenotypes between these two populations, in vivo assay showed significantly better homing potential of PB CD34 + cells than BM CD34 + cells. Significant correlation between homing and engraftment in AML samples was also noted. In addition, gene expression profiling of CD34 + cells from five paired BM and PB leukaemic samples showed that genes involved in G‐protein and prostaglandin signalling, chemotaxis and stress response, cell proliferation and apoptosis were down‐regulated in PB CD34 + myeloblasts. These data suggested that circulating primitive myeloblasts in AML are functionally different from those residing in the marrow compartment, and such differences may be partly regulated by the BM microenvironment. |
Author | Liang, Raymond Leung, Anskar Y. H. Chow, Howard C. H. Cheung, Alice M. S. |
Author_xml | – sequence: 1 givenname: Alice M. S. surname: Cheung fullname: Cheung, Alice M. S. – sequence: 2 givenname: Howard C. H. surname: Chow fullname: Chow, Howard C. H. – sequence: 3 givenname: Raymond surname: Liang fullname: Liang, Raymond – sequence: 4 givenname: Anskar Y. H. surname: Leung fullname: Leung, Anskar Y. H. |
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CitedBy_id | crossref_primary_10_1063_1_3610938 crossref_primary_10_1038_leu_2011_207 crossref_primary_10_1186_s12920_019_0540_5 crossref_primary_10_1371_journal_pone_0224097 crossref_primary_10_1016_j_leukres_2009_07_035 crossref_primary_10_1109_MNANO_2010_939832 crossref_primary_10_1016_j_exphem_2009_10_007 crossref_primary_10_1016_j_exphem_2013_05_287 crossref_primary_10_1053_j_seminoncol_2011_11_011 |
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Keywords | Acute myelogenous leukemia Hematology Stem cell Hematopoietic cell Malignant hemopathy peripheral blood Cell subpopulation Blood Myeloblast acute myeloid leukaemia Bone marrow Engraftment Homing phenomenon homing Comparative study Cancer |
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To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+... To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34(+)... Summary To examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34... SummaryTo examine the differences between primitive bone marrow (BM) and peripheral blood (PB) myeloblasts in acute myeloid leukaemia (AML), we compared CD34+... |
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SubjectTerms | acute myeloid leukaemia Adult Aged Animals Antigens, CD34 - analysis Antigens, Neoplasm - analysis Biological and medical sciences bone marrow Bone Marrow Cells - physiology engraftment Female Gene Expression Profiling - methods Graft Survival Granulocyte Precursor Cells - physiology Hematologic and hematopoietic diseases homing Humans Immunophenotyping Leukemia, Myeloid, Acute - blood Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Mice Mice, SCID Middle Aged Neoplasm Transplantation peripheral blood Prospective Studies Reverse Transcriptase Polymerase Chain Reaction - methods Transplantation, Heterologous |
Title | A comparative study of bone marrow and peripheral blood CD34+ myeloblasts in acute myeloid leukaemia |
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