Comparison of the effects of fasting morning, fasting evening and fed bedtime administration of tenatoprazole on intragastric pH in healthy volunteers: a randomized three‐way crossover study

• Published in: Alimentary pharmacology & therapeutics Vol. 23; no. 8; pp. 1179 - 1187
• Main Authors: THOMSON, A. B. R., COHEN, P., FICHEUX, H., FIORENTINI, P., DOMAGALA, F., HOMERIN, M., TACCOEN, A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2006; Blackwell
• Subjects: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Analysis of Variance; Anti-Ulcer Agents - blood; Anti-Ulcer Agents - pharmacokinetics; Anti-Ulcer Agents - pharmacology; Biological and medical sciences; Circadian Rhythm; Cross-Over Studies; Digestive system; Drug Administration Schedule; Eating; Fasting; Gastric Acidity Determination; Gastric Juice - metabolism; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter; Humans; Hydrogen-Ion Concentration; Imidazoles - blood; Imidazoles - pharmacokinetics; Imidazoles - pharmacology; Male; Medical sciences; Omeprazole - analogs & derivatives; Omeprazole - blood; Omeprazole - pharmacokinetics; Omeprazole - pharmacology; Pharmacology. Drug treatments; Pyridines - blood; Pyridines - pharmacokinetics; Pyridines - pharmacology; Statistics, Nonparametric; Human; Randomization; Fasting; Healthy subject; pH; Antiulcer agent; Tenatoprazole; Gastrointestinal; Crossover study; Comparative study; Feeding

Background  The effectiveness of proton pump inhibitors is influenced by meals and administration time. Aim  To compare the effects on intragastric acidity of times of dosing of tenatoprazole, a novel imidazopyridine‐based proton pump inhibitor with a prolonged plasma half‐life. Methods  This random...