Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development

• Published in: Development (Cambridge) Vol. 142; no. 23; pp. 4139 - 4150
• Main Authors: Al Alam, Denise, El Agha, Elie, Sakurai, Reiko, Kheirollahi, Vahid, Moiseenko, Alena, Danopoulos, Soula, Shrestha, Amit, Schmoldt, Carole, Quantius, Jennifer, Herold, Susanne, Chao, Cho-Ming, Tiozzo, Caterina, De Langhe, Stijn, Plikus, Maksim V, Thornton, Matthew, Grubbs, Brendan, Minoo, Parviz, Rehan, Virender K, Bellusci, Saverio
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists 01.12.2015
• Subjects: Adipose Tissue - metabolism; Animals; Cell Differentiation; Cell Line; Cell Separation; Cells, Cultured; Epithelial Cells - cytology; Female; Fibroblast Growth Factor 10 - metabolism; Fibroblasts - cytology; Flow Cytometry; Gene Deletion; Gene Expression Regulation, Developmental; Humans; Lipids - chemistry; Lung - embryology; Lung - metabolism; Mice; Mice, Transgenic; PPAR gamma - metabolism; Pulmonary Alveoli - metabolism; Receptor, Fibroblast Growth Factor, Type 2 - metabolism; Time Factors; Up-Regulation; Lipofibroblasts; Mesenchyme; Lung; Fgf10

Lipid-containing alveolar interstitial fibroblasts (lipofibroblasts) are increasingly recognized as an important component of the epithelial stem cell niche in the rodent lung. Although lipofibroblasts were initially believed merely to assist type 2 alveolar epithelial cells in surfactant production...