Protective effects of brain and muscle ARNT-like gene 1 on oxidized low-density lipoprotein-induced human brain microvascular endothelial cell injury by alleviating ferroptosis

• Published in: Human & experimental toxicology Vol. 42; p. 9603271231184630
• Main Authors: Yu, Shui, Zeng, Yijun, Ruan, Chenbin, Bai, Lei, Liang, Zhang
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2023; Sage Publications Ltd
• Subjects: ARNTL Transcription Factors - genetics; ARNTL Transcription Factors - metabolism; ARNTL Transcription Factors - pharmacology; Arteriosclerosis; Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism; Atherosclerosis; BMAL1 protein; Brain; Brain - metabolism; Brain injury; Cell injury; Cerebrovascular diseases; Damage; Density; Endothelial cells; Endothelial Cells - metabolism; Ferroptosis; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL - metabolism; Lipoproteins, LDL - pharmacology; Low density lipoprotein; Microvasculature; Muscles; Muscles - metabolism; NF-E2-Related Factor 2 - metabolism; Vascular diseases; ferroptosis; cerebrovascular disease; ARNT-like gene 1

Ferroptosis plays an important role in atherosclerotic cerebrovascular diseases. The brain and muscle ARNT-like gene 1 (BMAL1) is an important mediator in the progression of cerebrovascular diseases. However, whether BMAL1 regulates ferroptosis in atherosclerotic cerebrovascular diseases remains obs...