Exosomal microRNA Therapy for Non-Small-Cell Lung Cancer

With the progress of molecular diagnosis research on non-small cell lung cancer (NSCLC) cells, four identified categories of microRNAs have been found to be related to disease diagnosis, diagnosis of treatment resistance, prediction of prognosis, and drugs for treatment. To date, nine target mRNA/si...

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Published inTechnology in cancer research & treatment Vol. 22; p. 15330338231210731
Main Authors Chen, Jibing, Wu, Fasheng, Hou, Encun, Zeng, Jianying, Li, Fujun, Gao, Hongjun
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2023
Sage Publications Ltd
SAGE Publishing
Subjects
Blood vessels
Cancer therapies
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - therapy
Diagnosis
Drug therapy
Gene Expression Regulation, Neoplastic
Humans
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Lung Neoplasms - therapy
MicroRNAs
MicroRNAs - metabolism
miRNA
mRNA
Non-small cell lung carcinoma
Prognosis
Signal Transduction
Small cell lung carcinoma
Treatment resistance
microRNA
mRNA
signal pathway
exosomes
non-small cell lung cancer (NSCLC)
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Abstract With the progress of molecular diagnosis research on non-small cell lung cancer (NSCLC) cells, four identified categories of microRNAs have been found to be related to disease diagnosis, diagnosis of treatment resistance, prediction of prognosis, and drugs for treatment. To date, nine target mRNA/signal pathways have been confirmed for microRNA drug therapy both in vitro and in vivo. When microRNA drugs enter blood vessels, they target the tumor site and play a similar role to that of targeted drugs. However, whether they will produce serious off-target effects remains unknown, and further clinical research is needed. This review provides the first summary of microRNA therapy for NSCLC.
AbstractList With the progress of molecular diagnosis research on non-small cell lung cancer (NSCLC) cells, four identified categories of microRNAs have been found to be related to disease diagnosis, diagnosis of treatment resistance, prediction of prognosis, and drugs for treatment. To date, nine target mRNA/signal pathways have been confirmed for microRNA drug therapy both in vitro and in vivo. When microRNA drugs enter blood vessels, they target the tumor site and play a similar role to that of targeted drugs. However, whether they will produce serious off-target effects remains unknown, and further clinical research is needed. This review provides the first summary of microRNA therapy for NSCLC.With the progress of molecular diagnosis research on non-small cell lung cancer (NSCLC) cells, four identified categories of microRNAs have been found to be related to disease diagnosis, diagnosis of treatment resistance, prediction of prognosis, and drugs for treatment. To date, nine target mRNA/signal pathways have been confirmed for microRNA drug therapy both in vitro and in vivo. When microRNA drugs enter blood vessels, they target the tumor site and play a similar role to that of targeted drugs. However, whether they will produce serious off-target effects remains unknown, and further clinical research is needed. This review provides the first summary of microRNA therapy for NSCLC.
With the progress of molecular diagnosis research on non-small cell lung cancer (NSCLC) cells, four identified categories of microRNAs have been found to be related to disease diagnosis, diagnosis of treatment resistance, prediction of prognosis, and drugs for treatment. To date, nine target mRNA/signal pathways have been confirmed for microRNA drug therapy both in vitro and in vivo. When microRNA drugs enter blood vessels, they target the tumor site and play a similar role to that of targeted drugs. However, whether they will produce serious off-target effects remains unknown, and further clinical research is needed. This review provides the first summary of microRNA therapy for NSCLC.
Author Li, Fujun
Hou, Encun
Gao, Hongjun
Wu, Fasheng
Chen, Jibing
Zeng, Jianying
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  email: gao4056@163.com
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37936417$$D View this record in MEDLINE/PubMed
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crossref_primary_10_1016_j_prp_2024_155619
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Keywords microRNA
mRNA
signal pathway
exosomes
non-small cell lung cancer (NSCLC)
Language English
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Snippet With the progress of molecular diagnosis research on non-small cell lung cancer (NSCLC) cells, four identified categories of microRNAs have been found to be...
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SubjectTerms Blood vessels
Cancer therapies
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - therapy
Diagnosis
Drug therapy
Gene Expression Regulation, Neoplastic
Humans
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Lung Neoplasms - therapy
MicroRNAs
MicroRNAs - metabolism
miRNA
mRNA
Non-small cell lung carcinoma
Prognosis
Signal Transduction
Small cell lung carcinoma
Treatment resistance
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Title Exosomal microRNA Therapy for Non-Small-Cell Lung Cancer
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