Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/ JNK and potentiates cisplatin efficacy in gastric cancer treatment - Jiang, Xiao-yan; Zhu, Xiao-song; Xu, Hong-ya; Zhao, Zhong-xi; Li, Si-ying; Li, Shan-zhong; Cai, Jian-hua; Cao, Ji-min (Acta pharmacologica Sinica, 2017)
Keywords: AKT protein; Allyl Compounds - pharmacology; Animals; Antineoplastic Agents - pharmacology; Antitumor activity; Antitumor agents; Apoptosis; Apoptosis - drug effects; Bcl protein; Bcl-2 protein; BGC-823; Biomedical and Life Sciences; Biomedicine; Cancer therapies; Caspase; Cell cycle; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Diallyl trisulfide; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Garlic; Gastric cancer; Humans; Immunology; Internal Medicine; JNK; JNK Mitogen-Activated Protein Kinases - metabolism; JNK protein; MAP kinase; Medical Microbiology; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - pathology; NF-E2-Related Factor 2 - antagonists & inhibitors; NF-E2-Related Factor 2 - metabolism; Oncogene Protein v-akt - antagonists & inhibitors; Oncogene Protein v-akt - metabolism; Original; original-article; p38; p38 Mitogen-Activated Protein Kinases - metabolism; Pharmacology/Toxicology; Quality of life; Side effects; Stomach Neoplasms - drug therapy; Stomach Neoplasms - pathology; Structure-Activity Relationship; Sulfides - pharmacology; Tumor Cells, Cultured; Tumors; Vaccine; Xenografts; 大蒜素; 抑制肿瘤; 胃癌细胞; 辅助治疗; 顺铂; p38/JNK; diallyl trisulfide; apoptosis; cisplatin; human gastric cancer; cell cycle arrest; Nrf2/Akt; enhanced efficacy