Immune infiltrates in the breast cancer microenvironment: detection, characterization and clinical implication

• Published in: Breast cancer (Tokyo, Japan) Vol. 24; no. 1; pp. 3 - 15
• Main Authors: Burugu, Samantha, Asleh-Aburaya, Karama, Nielsen, Torsten O.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.01.2017; Springer
• Subjects: B cells; Biomarkers, Tumor - immunology; Breast cancer; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Cancer; Cancer Research; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; CTLA-4 Antigen - immunology; Development and progression; Diagnosis; Female; Humans; Immune response; Immunity, Innate; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - pathology; Macrophages - immunology; Macrophages - pathology; Medicine; Medicine & Public Health; Oncology; Oncology, Experimental; Prognosis; Programmed Cell Death 1 Receptor; Special Feature; Surgery; Surgical Oncology; T cells; T-Lymphocytes, Regulatory - immunology; Tumor Microenvironment - immunology; Immune microenvironment; Breast cancer; Prognosis; Tumor-infiltrating lymphocytes; Prediction

Although unlike melanoma, breast cancer is not generally viewed as a highly immunogenic cancer, recent studies have described a rich tumor immune microenvironment in a subset of breast cancers. These immune infiltrates, comprised cells from the innate and adaptive immune response, can be detected an...