Analysis of interleukin-17 and interleukin-23 for estimating disease activity and predicting the response to treatment in active lupus nephritis patients

• Published in: Immunology letters Vol. 210; pp. 33 - 39
• Main Authors: Dedong, Huang, Feiyan, Zhu, Jie, Shi, Xiaowei, Lai, Shaoyang, Wang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2019
• Subjects: Adult; Cytokines - metabolism; Disease Management; Female; Humans; interleukin-17; Interleukin-17 - metabolism; interleukin-23; Interleukin-23 - metabolism; Lupus Erythematosus, Systemic - complications; Lupus nephritis; Lupus Nephritis - diagnosis; Lupus Nephritis - etiology; Lupus Nephritis - metabolism; Lupus Nephritis - therapy; Male; Middle Aged; ROC Curve; Severity of Illness Index; Systemic lupus erythematosus; interleukin-17; Systemic lupus erythematosus; Lupus nephritis; interleukin-23

•IL-17 and IL-23 may involve and contribute to lupus nephritis.•IL-17 could be used as a biomarker for lupus nephritis clinical and pathological active index.•IL-23 could be used as a predictor for predicting response to treatment in patients with active lupus nephritis. Renal biopsy is a “gold stan...