A fungal family of lytic polysaccharide monooxygenase-like copper proteins

• Published in: Nature chemical biology Vol. 16; no. 3; pp. 345 - 350
• Main Authors: Labourel, Aurore, Frandsen, Kristian E. H., Zhang, Feng, Brouilly, Nicolas, Grisel, Sacha, Haon, Mireille, Ciano, Luisa, Ropartz, David, Fanuel, Mathieu, Martin, Francis, Navarro, David, Rosso, Marie-Noëlle, Tandrup, Tobias, Bissaro, Bastien, Johansen, Katja S., Zerva, Anastasia, Walton, Paul H., Henrissat, Bernard, Leggio, Leila Lo, Berrin, Jean-Guy
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2020; Nature Publishing Group
• Subjects: 631/535/1266; 631/92/221; 631/92/321; 631/92/607; Binding Sites; Biochemical Engineering; Biochemistry; Biodegradation; Bioorganic Chemistry; Biopolymers; Cell Biology; Cellulose; Cellulose - metabolism; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Chitin; Chitin - metabolism; Copper; Copper - metabolism; Degradation; Ectomycorrhizas; Fungal Proteins - chemistry; Fungal Proteins - metabolism; Fungi; Fungi - metabolism; Histidine; Hunting; Hyphae; Life Sciences; Mixed Function Oxygenases - chemistry; Mixed Function Oxygenases - metabolism; Mixed Function Oxygenases - ultrastructure; Monooxygenase; Oxidation-Reduction; Phylogeny; Polysaccharides; Polysaccharides - metabolism; Proteins; Saccharides; polysaccharide; champignon ectomycorhizien; dégradation oxydative; protéine à cuivre; enzyme lytique

Lytic polysaccharide monooxygenases (LPMOs) are copper-containing enzymes that play a key role in the oxidative degradation of various biopolymers such as cellulose and chitin. While hunting for new LPMOs, we identified a new family of proteins, defined here as X325, in various fungal lineages. The...