Enterobacter sakazakii: infectivity and enterotoxin production in vitro and in vivo

• Published in: Journal of food protection Vol. 66; no. 3; pp. 370 - 375
• Main Authors: Pagotto, F.J, Nazarowec-White, M, Bidawid, S, Farber, J.M
• Format: Journal Article
• Language: English
• Published: Des Moines, IA International Association of Milk, Food and Environmental Sanitarians 01.03.2003
• Subjects: Administration, Oral; animal models; Animals; Animals, Suckling; bacterial contamination; bacterial motility; Bacteriology; bioassays; Biological and medical sciences; biological production; cell culture; cell lines; Cells, Cultured; Cronobacter sakazakii; dried foods; Enterobacter - metabolism; Enterobacter - pathogenicity; enterotoxins; Enterotoxins - biosynthesis; food contamination; Food industries; Food Microbiology; food pathogens; Fundamental and applied biological sciences. Psychology; Humans; in vitro studies; in vivo studies; Infant; Infant Food - microbiology; infant formulas; Injections, Intraperitoneal; intraperitoneal injection; lethal dose; Lethal Dose 50; meningitis; Meningitis, Bacterial - etiology; Mice; Microbiology; oral administration; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains; suckling; Virulence; Pathogenesis; Rodentia; Adrenal cortex; Monkey; Suckling animal; In vitro; CHO cell line; Kidney; Toxin; In vivo; Vertebrata; Cell line; Mammalia; Enterobacter; Mouse; Infant food; Infectivity; Primates; Enterotoxin; Bacteria; Hamster; Enterobacteriaceae

Enterobacter sakazakii has been implicated as the causal organism in a severe form of neonatal meningitis, with reported mortality rates of 40 to 80%. Dried infant formula has been identified as a potential source of the organism in both outbreaks and sporadic cases. In this study, clinical and food...