Cisplatin-induced renal interstitial fibrosis in neonatal rats, developing as solitary nephron unit lesions

• Published in: Toxicologic pathology Vol. 33; no. 2; p. 207
• Main Authors: Yamate, Jyoji, Machida, Yuuko, Ide, Mika, Kuwamura, Mitsuru, Kotani, Takao, Sawamoto, Osamu, LaMarre, Jonathan
• Format: Journal Article
• Language: English
• Published: United States 01.01.2005
• Subjects: Actins - metabolism; Animals; Animals, Newborn; Antineoplastic Agents - toxicity; Apoptosis - drug effects; Biomarkers - metabolism; Body Weight - drug effects; Cisplatin - toxicity; Disease Models, Animal; Fibrosis; In Situ Nick-End Labeling; Macrophages - drug effects; Macrophages - metabolism; Nephritis, Interstitial - chemically induced; Nephritis, Interstitial - metabolism; Nephritis, Interstitial - pathology; Nephrons - drug effects; Nephrons - metabolism; Nephrons - pathology; Rats; Rats, Inbred F344; RNA, Messenger - metabolism; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism; Transforming Growth Factor beta1

Cisplatin (CDDP)-induced renal lesions in rats prove a useful model for analysis of the pathogenesis of post-tubular injury-renal interstitial fibrosis. This study investigated the histopathological changes in 10-day-old neonatal rats induced by a single injection of CDDP (4.5 mg/kg). Compared with...