Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk
Control of gene and protein expression is required for cellular homeostasis and is disrupted in disease. Following transcription, mRNA turnover and translation is modulated, most notably by microRNAs (miRNAs). This modulation is controlled by transcriptional and post-transcriptional events that alte...
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| Published in | Critical reviews in biochemistry and molecular biology Vol. 53; no. 3; pp. 231 - 245 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Taylor & Francis
01.06.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Control of gene and protein expression is required for cellular homeostasis and is disrupted in disease. Following transcription, mRNA turnover and translation is modulated, most notably by microRNAs (miRNAs). This modulation is controlled by transcriptional and post-transcriptional events that alter the availability of miRNAs for target binding. Recent studies have proposed that some transcripts - termed competitive endogenous RNAs (ceRNAs) - sequester a miRNA and diminish its repressive effects on other transcripts. Such ceRNAs thus mutually alter each other's abundance by competing for binding to a common set of miRNAs. Some question the relevance of ceRNA crosstalk, arguing that an individual transcript, when its abundance lies within a physiological range of gene expression, will fail to compete for miRNA binding due to the high abundance of other miRNA binding sites across the transcriptome. Despite this, some experimental evidence is consistent with the ceRNA hypothesis. In this review, we draw upon existing data to highlight mechanistic and theoretical aspects of ceRNA crosstalk. Our intent is to propose how understanding of ceRNA crosstalk mechanisms can be improved and what evidence is required to demonstrate a ceRNA mechanism. A greater understanding of factors affecting ceRNA crosstalk should shed light on its relevance in physiological states. |
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| AbstractList | Control of gene and protein expression is required for cellular homeostasis and is disrupted in disease. Following transcription, mRNA turnover and translation is modulated, most notably by microRNAs (miRNAs). This modulation is controlled by transcriptional and post-transcriptional events that alter the availability of miRNAs for target binding. Recent studies have proposed that some transcripts - termed competitive endogenous RNAs (ceRNAs) - sequester a miRNA and diminish its repressive effects on other transcripts. Such ceRNAs thus mutually alter each other's abundance by competing for binding to a common set of miRNAs. Some question the relevance of ceRNA crosstalk, arguing that an individual transcript, when its abundance lies within a physiological range of gene expression, will fail to compete for miRNA binding due to the high abundance of other miRNA binding sites across the transcriptome. Despite this, some experimental evidence is consistent with the ceRNA hypothesis. In this review, we draw upon existing data to highlight mechanistic and theoretical aspects of ceRNA crosstalk. Our intent is to propose how understanding of ceRNA crosstalk mechanisms can be improved and what evidence is required to demonstrate a ceRNA mechanism. A greater understanding of factors affecting ceRNA crosstalk should shed light on its relevance in physiological states. Control of gene and protein expression is required for cellular homeostasis and is disrupted in disease. Following transcription, mRNA turnover and translation is modulated, most notably by microRNAs (miRNAs). This modulation is controlled by transcriptional and post-transcriptional events that alter the availability of miRNAs for target binding. Recent studies have proposed that some transcripts - termed competitive endogenous RNAs (ceRNAs) - sequester a miRNA and diminish its repressive effects on other transcripts. Such ceRNAs thus mutually alter each other's abundance by competing for binding to a common set of miRNAs. Some question the relevance of ceRNA crosstalk, arguing that an individual transcript, when its abundance lies within a physiological range of gene expression, will fail to compete for miRNA binding due to the high abundance of other miRNA binding sites across the transcriptome. Despite this, some experimental evidence is consistent with the ceRNA hypothesis. In this review, we draw upon existing data to highlight mechanistic and theoretical aspects of ceRNA crosstalk. Our intent is to propose how understanding of ceRNA crosstalk mechanisms can be improved and what evidence is required to demonstrate a ceRNA mechanism. A greater understanding of factors affecting ceRNA crosstalk should shed light on its relevance in physiological states.Control of gene and protein expression is required for cellular homeostasis and is disrupted in disease. Following transcription, mRNA turnover and translation is modulated, most notably by microRNAs (miRNAs). This modulation is controlled by transcriptional and post-transcriptional events that alter the availability of miRNAs for target binding. Recent studies have proposed that some transcripts - termed competitive endogenous RNAs (ceRNAs) - sequester a miRNA and diminish its repressive effects on other transcripts. Such ceRNAs thus mutually alter each other's abundance by competing for binding to a common set of miRNAs. Some question the relevance of ceRNA crosstalk, arguing that an individual transcript, when its abundance lies within a physiological range of gene expression, will fail to compete for miRNA binding due to the high abundance of other miRNA binding sites across the transcriptome. Despite this, some experimental evidence is consistent with the ceRNA hypothesis. In this review, we draw upon existing data to highlight mechanistic and theoretical aspects of ceRNA crosstalk. Our intent is to propose how understanding of ceRNA crosstalk mechanisms can be improved and what evidence is required to demonstrate a ceRNA mechanism. A greater understanding of factors affecting ceRNA crosstalk should shed light on its relevance in physiological states. |
| Author | Sirey, Tamara Smillie, Claire L. Ponting, Chris P. |
| Author_xml | – sequence: 1 givenname: Claire L. orcidid: 0000-0003-1350-2301 surname: Smillie fullname: Smillie, Claire L. organization: MRC Human Genetics Unit within the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK – sequence: 2 givenname: Tamara orcidid: 0000-0001-5606-2858 surname: Sirey fullname: Sirey, Tamara organization: MRC Human Genetics Unit within the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK – sequence: 3 givenname: Chris P. orcidid: 0000-0003-0202-7816 surname: Ponting fullname: Ponting, Chris P. organization: MRC Human Genetics Unit within the Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29569941$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.molcel.2014.09.018 10.1038/emboj.2013.52 10.1038/nrg3853 10.1038/ncb1265 10.1038/nrg3765 10.1016/j.ymeth.2007.04.007 10.1371/journal.pone.0028730 10.1038/nsmb.2516 10.1016/j.cell.2011.09.041 10.1101/gad.1399806 10.1038/ng2079 10.1126/science.1187058 10.1186/gb-2003-5-1-r1 10.1016/j.cell.2011.09.029 10.1016/j.bpj.2013.01.012 10.1016/j.molcel.2007.06.017 10.1093/nar/gkq285 10.7554/eLife.05005 10.1016/j.molcel.2014.03.045 10.1038/nature09144 10.1101/gr.181974.114 10.1016/j.cell.2015.02.043 10.1073/pnas.0608845103 10.1126/science.aaf8995 10.1038/s41598-017-12973-5 10.1158/1541-7786.MCR-15-0061 10.1128/MCB.00128-07 10.1093/nar/gkm133 10.1016/j.devcel.2013.03.002 10.1101/gr.082701.108 10.1093/nar/gkt1393 10.1016/j.cell.2011.09.028 10.1016/S0092-8674(04)00045-5 10.1016/j.molcel.2010.09.027 10.1016/j.cell.2004.12.035 10.1093/nar/gkq1003 10.1126/science.1258040 10.1016/j.cell.2012.02.005 10.1002/wdev.223 10.1038/nature11993 10.1073/pnas.1222509110 10.1016/j.cell.2015.06.029 10.1038/nature13182 10.1007/s10735-016-9659-2 10.1038/ncb1274 10.1083/jcb.200309008 10.1101/gad.1064703 10.1371/journal.pone.0020746 10.1016/j.cell.2014.05.047 10.1016/j.molcel.2016.09.027 10.1186/gb-2012-13-11-r102 10.1038/nature21025 10.1016/j.semcdb.2016.05.017 10.1038/msb.2010.24 10.1073/pnas.1424217112 10.1161/CIRCRESAHA.112.267732 10.1186/gb-2011-12-11-132 10.1016/j.cell.2011.07.014 10.1038/nmeth1079 10.1016/j.cell.2015.06.032 10.1016/j.cell.2009.01.002 10.1091/mbc.01-11-0544 10.1093/nar/gkv720 10.1126/science.aam8526 10.1038/nature11928 10.1093/nar/gkw116 10.1371/journal.pone.0020220 10.1038/nmeth.2078 10.1021/bi00527a028 10.1038/nsmb.2902 10.1093/nar/gkx640 10.1038/ng.2653 |
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| Snippet | Control of gene and protein expression is required for cellular homeostasis and is disrupted in disease. Following transcription, mRNA turnover and translation... |
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| SubjectTerms | Animals Gene Expression Regulation - physiology Humans MicroRNAs - genetics MicroRNAs - metabolism Models, Biological Review RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptome - physiology |
| Title | Complexities of post-transcriptional regulation and the modeling of ceRNA crosstalk |
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