Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks

• Published in: Nucleic acids research Vol. 40; no. 10; pp. 4273 - 4287
• Main Authors: Schaefer, Martin H., Wanker, Erich E., Andrade-Navarro, Miguel A.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.05.2012
• Subjects: Amino Acid Sequence; Animals; Ataxia; Computational Biology; Computer programs; Evolution; Evolution, Molecular; Genome, Human; genomics; Humans; Information systems; Molecular Sequence Data; Multiprotein Complexes - chemistry; Peptides - genetics; Phylogeny; Polyglutamine; polyglutamine diseases; Protein interaction; Protein Interaction Domains and Motifs; Protein Interaction Mapping; Proteins - chemistry; Proteins - genetics; Proteins - physiology; Sequence Alignment; trinucleotide repeat diseases; Trinucleotide Repeats

Expanded runs of consecutive trinucleotide CAG repeats encoding polyglutamine (polyQ) stretches are observed in the genes of a large number of patients with different genetic diseases such as Huntington's and several Ataxias. Protein aggregation, which is a key feature of most of these diseases...