Efficacy of Bacillus Calmette-Guérin Strains for Treatment of Nonmuscle Invasive Bladder Cancer: A Systematic Review and Network Meta-Analysis

• Published in: The Journal of urology Vol. 198; no. 3; pp. 503 - 510
• Main Authors: Boehm, Brock E, Cornell, John E, Wang, Hanzhang, Mukherjee, Neelam, Oppenheimer, Jacob S, Svatek, Robert S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2017
• Subjects: Adjuvants, Immunologic - therapeutic use; BCG vaccine; BCG Vaccine - therapeutic use; Humans; immunotherapy; Mycobacterium bovis; urinary bladder neoplasms; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - pathology; Urology; carcinoma in situ; FDA; bacillus Calmette-Guérin; NMIBC; Netherlands National Institute for Public Health and the Environment; BCG; RIVM; MeSH; PRISMA; SUCRA; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; nonmuscle invasive bladder cancer; CIS; BCG vaccine; surface under the cumulative ranking curve; immunotherapy; urinary bladder neoplasms; Medical Subject Headings; United States Food and Drug Administration

Purpose We sought to determine the efficacy of genetically distinct bacillus Calmette-Guérin strains in preventing disease recurrence in patients with nonmuscle invasive bladder cancer. Materials and Methods We conducted a systematic review and network meta-analysis of trials evaluating bacillus Cal...