Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation
The molecular basis of cell signal-regulated alternative splicing at the 3' splice site remains largely unknown. We isolated a protein kinase A-responsive ribonucleic acid (RNA) element from a 3' splice site of the synaptosomal-associated protein 25 (Snap25) gene for forskolin-inhibited sp...
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Published in | Nucleic acids research Vol. 40; no. 16; pp. 8059 - 8071 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Oxford University Press
01.09.2012
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Abstract | The molecular basis of cell signal-regulated alternative splicing at the 3' splice site remains largely unknown. We isolated a protein kinase A-responsive ribonucleic acid (RNA) element from a 3' splice site of the synaptosomal-associated protein 25 (Snap25) gene for forskolin-inhibited splicing during neuronal differentiation of rat pheochromocytoma PC12 cells. The element binds specifically to heterogeneous nuclear ribonucleo protein (hnRNP) K in a phosphatase-sensitive way, which directly competes with the U2 auxiliary factor U2AF65, an essential component of early spliceosomes. Transcripts with similarly localized hnRNP K target motifs upstream of alternative exons are enriched in genes often associated with neurological diseases. We show that such motifs upstream of the Runx1 exon 6 also bind hnRNP K, and importantly, hnRNP K is required for forskolin-induced repression of the exon. Interestingly, this exon encodes the peptide domain that determines the switch of the transcriptional repressor/activator activity of Runx1, a change known to be critical in specifying neuron lineages. Consistent with an important role of the target genes in neurons, knocking down hnRNP K severely disrupts forskolin-induced neurite growth. Thus, through hnRNP K, the neuronal differentiation stimulus forskolin targets a critical 3' splice site component of the splicing machinery to control alternative splicing of crucial genes. This also provides a regulated direct competitor of U2AF65 for cell signal control of 3' splice site usage. |
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AbstractList | The molecular basis of cell signal-regulated alternative splicing at the 3′ splice site remains largely unknown. We isolated a protein kinase A-responsive ribonucleic acid (RNA) element from a 3′ splice site of the synaptosomal-associated protein 25 (
Snap25)
gene for forskolin-inhibited splicing during neuronal differentiation of rat pheochromocytoma PC12 cells. The element binds specifically to heterogeneous nuclear ribonucleo protein (hnRNP) K in a phosphatase-sensitive way, which directly competes with the U2 auxiliary factor U2AF65, an essential component of early spliceosomes. Transcripts with similarly localized hnRNP K target motifs upstream of alternative exons are enriched in genes often associated with neurological diseases. We show that such motifs upstream of the Runx1 exon 6 also bind hnRNP K, and importantly, hnRNP K is required for forskolin-induced repression of the exon. Interestingly, this exon encodes the peptide domain that determines the switch of the transcriptional repressor/activator activity of Runx1, a change known to be critical in specifying neuron lineages. Consistent with an important role of the target genes in neurons, knocking down hnRNP K severely disrupts forskolin-induced neurite growth. Thus, through hnRNP K, the neuronal differentiation stimulus forskolin targets a critical 3′ splice site component of the splicing machinery to control alternative splicing of crucial genes. This also provides a regulated direct competitor of U2AF65 for cell signal control of 3′ splice site usage. The molecular basis of cell signal-regulated alternative splicing at the 3' splice site remains largely unknown. We isolated a protein kinase A-responsive ribonucleic acid (RNA) element from a 3' splice site of the synaptosomal-associated protein 25 (Snap25) gene for forskolin-inhibited splicing during neuronal differentiation of rat pheochromocytoma PC12 cells. The element binds specifically to heterogeneous nuclear ribonucleo protein (hnRNP) K in a phosphatase-sensitive way, which directly competes with the U2 auxiliary factor U2AF65, an essential component of early spliceosomes. Transcripts with similarly localized hnRNP K target motifs upstream of alternative exons are enriched in genes often associated with neurological diseases. We show that such motifs upstream of the Runx1 exon 6 also bind hnRNP K, and importantly, hnRNP K is required for forskolin-induced repression of the exon. Interestingly, this exon encodes the peptide domain that determines the switch of the transcriptional repressor/activator activity of Runx1, a change known to be critical in specifying neuron lineages. Consistent with an important role of the target genes in neurons, knocking down hnRNP K severely disrupts forskolin-induced neurite growth. Thus, through hnRNP K, the neuronal differentiation stimulus forskolin targets a critical 3' splice site component of the splicing machinery to control alternative splicing of crucial genes. This also provides a regulated direct competitor of U2AF65 for cell signal control of 3' splice site usage. |
Author | Feng, Dairong Lobo, Vincent G Razanau, Aleh Cao, Wenguang Xie, Jiuyong |
AuthorAffiliation | 1 Department of Physiology and 2 Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada |
AuthorAffiliation_xml | – name: 1 Department of Physiology and 2 Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada |
Author_xml | – sequence: 1 givenname: Wenguang surname: Cao fullname: Cao, Wenguang organization: Department of Physiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada – sequence: 2 givenname: Aleh surname: Razanau fullname: Razanau, Aleh – sequence: 3 givenname: Dairong surname: Feng fullname: Feng, Dairong – sequence: 4 givenname: Vincent G surname: Lobo fullname: Lobo, Vincent G – sequence: 5 givenname: Jiuyong surname: Xie fullname: Xie, Jiuyong |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22684629$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1242/dev.022236 10.1038/nrn2057 10.1242/dev.066993 10.1038/nsmb1260 10.1074/jbc.M900393200 10.1016/j.bbagrm.2010.01.003 10.1002/ajmg.a.33478 10.1074/jbc.M201083200 10.1016/j.tibs.2011.04.003 10.1126/science.7761834 10.1016/S0968-0004(00)01604-2 10.1371/journal.pgen.1000278 10.1016/j.neuron.2006.01.008 10.1126/science.280.5362.443 10.1038/418236a 10.1038/35060131 10.4161/rna.8.6.16691 10.1074/jbc.M109.019711 10.1074/jbc.M110.204453 10.1016/j.mcn.2011.08.009 10.4161/rna.7.1.10402 10.1038/ejhg.2008.89 10.1016/S0021-9258(19)34116-X 10.1073/pnas.91.9.4004 10.1002/gcc.20050 10.1523/JNEUROSCI.1940-04.2004 10.1042/BJ20100396 10.1128/MCB.00726-08 10.1038/nn1631 10.1016/S0168-9525(00)02176-4 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2 10.1074/jbc.M010594200 10.1186/1471-2164-12-229 10.1128/MCB.22.1.221-230.2002 10.1016/j.cancergencyto.2010.07.116 10.1016/j.molcel.2011.08.014 10.1007/978-1-4419-7913-1_5 10.1038/35073593 10.1016/S1054-3589(10)58016-5 10.1097/00001756-200103260-00011 10.1074/jbc.275.1.651 10.1073/pnas.0711299105 10.1073/pnas.232688199 10.1111/j.1399-0004.2009.01289.x 10.1038/41137 10.1038/nature07509 10.1073/pnas.1432696100 10.1038/362171a0 10.1093/nar/gkl884 10.1038/nature10171 10.1038/nrn2237 10.1038/nrm1467 10.1016/j.bbagrm.2008.01.003 10.1017/S1355838200000376 10.1146/annurev.biochem.72.121801.161720 10.1002/gcc.10302 10.1016/j.cell.2009.02.011 10.1074/jbc.R700034200 10.1002/jcp.20538 10.1038/71207 10.1016/j.bbamcr.2007.02.006 10.1073/pnas.0900342106 10.1261/rna.876308 10.1016/j.yexcr.2007.05.014 10.1074/jbc.M109.056465 10.1016/j.cell.2011.08.023 10.1261/rna.577707 10.1093/nar/gkn207 10.1016/S0092-8674(02)00730-4 10.1523/JNEUROSCI.5108-04.2005 10.1016/j.bbadis.2008.09.017 10.1007/978-0-387-77374-2_8 10.1074/jbc.M805113200 10.1002/gcc.2870110405 10.1016/S0301-0082(01)00007-7 |
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References | 10612281 - Electrophoresis. 1999 Dec;20(18):3551-67 10625417 - Nat Struct Biol. 2000 Jan;7(1):14-6 20795951 - Biochem J. 2010 Sep 15;430(3):379-92 18369186 - RNA. 2008 May;14(5):802-13 21569303 - BMC Genomics. 2011;12:229 18644864 - Mol Cell Biol. 2008 Oct;28(19):6033-43 21596569 - Trends Biochem Sci. 2011 Aug;36(8):397-404 18440980 - Nucleic Acids Res. 2008 Jun;36(10):3320-31 19043548 - PLoS Genet. 2008 Nov;4(11):e1000278 11231586 - Nat Cell Biol. 2001 Mar;3(3):325-30 21924763 - Cell. 2011 Sep 30;147(1):132-46 20074680 - Biochim Biophys Acta. 2010 May-Jun;1799(5-6):448-53 11278705 - J Biol Chem. 2001 May 18;276(20):17484-96 19017650 - J Biol Chem. 2009 Jan 16;284(3):1505-13 21367856 - J Biol Chem. 2011 Apr 22;286(16):14639-48 17895907 - Nat Rev Neurosci. 2007 Nov;8(11):819-31 10916158 - Trends Biochem Sci. 2000 Aug;25(8):381-8 18380344 - Adv Exp Med Biol. 2007;623:123-47 15470145 - J Neurosci. 2004 Oct 6;24(40):8796-805 15728845 - J Neurosci. 2005 Feb 23;25(8):2050-61 15340380 - Nat Rev Mol Cell Biol. 2004 Sep;5(9):727-38 21957496 - RNA Biol. 2011 Nov-Dec;8(6):1061-72 17400307 - Biochim Biophys Acta. 2007 Jun;1773(6):912-23 17594903 - Exp Cell Res. 2007 Aug 1;313(13):2795-809 18258215 - Biochim Biophys Acta. 2008 Aug;1779(8):438-52 19946215 - RNA Biol. 2010 Jan-Feb;7(1):56-64 11739736 - Mol Cell Biol. 2002 Jan;22(1):221-30 20655491 - Adv Pharmacol. 2010;58:427-51 2156866 - J Biol Chem. 1990 Mar 25;265(9):5267-72 12110900 - Nature. 2002 Jul 11;418(6894):236-43 20578134 - Am J Med Genet A. 2010 Jul;152A(7):1711-7 11173120 - Trends Genet. 2001 Feb;17(2):100-7 10617663 - J Biol Chem. 2000 Jan 7;275(1):651-6 16250015 - J Cell Physiol. 2006 Jun;207(3):582-93 11309619 - Nature. 2001 Apr 19;410(6831):936-9 17108355 - Nucleic Acids Res. 2007 Jan;35(Database issue):D93-8 17237804 - Nat Rev Neurosci. 2007 Feb;8(2):114-27 17507659 - RNA. 2007 Jul;13(7):1103-15 7680770 - Nature. 1993 Mar 11;362(6416):171-5 16446142 - Neuron. 2006 Feb 2;49(3):379-93 18427115 - Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6451-6 19239895 - Cell. 2009 Feb 20;136(4):777-93 19470458 - Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9203-8 12518064 - Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):183-8 9237760 - Nature. 1997 Jul 24;388(6640):397-400 19840947 - J Biol Chem. 2009 Dec 11;284(50):35154-64 7761834 - Science. 1995 May 26;268(5214):1173-6 18024427 - J Biol Chem. 2008 Jan 18;283(3):1223-7 18978772 - Nature. 2008 Nov 27;456(7221):470-6 8171026 - Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4004-8 18478040 - Eur J Hum Genet. 2008 Aug;16(8):1014-8 12626338 - Annu Rev Biochem. 2003;72:291-336 12851456 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8776-81 21906677 - Mol Cell Neurosci. 2012 Jan;49(1):23-31 21618826 - Adv Exp Med Biol. 2010;706:59-75 19520842 - J Biol Chem. 2009 Aug 7;284(32):21458-67 20875871 - Cancer Genet Cytogenet. 2010 Oct 15;202(2):94-100 11867641 - J Biol Chem. 2002 May 10;277(19):16614-23 7533526 - Genes Chromosomes Cancer. 1994 Dec;11(4):226-36 19386606 - J Biol Chem. 2009 Jun 12;284(24):16191-201 21693523 - Development. 2011 Jul;138(14):3079-90 18992329 - Biochim Biophys Acta. 2009 Jan;1792(1):14-26 21884984 - Mol Cell. 2011 Sep 2;43(5):843-50 10864047 - RNA. 2000 Jun;6(6):901-11 19863549 - Clin Genet. 2010 Feb;77(2):145-54 12015979 - Cell. 2002 May 3;109(3):285-96 9545224 - Science. 1998 Apr 17;280(5362):443-6 11277561 - Neuroreport. 2001 Mar 26;12(4):673-7 14695990 - Genes Chromosomes Cancer. 2004 Feb;39(2):110-8 15188461 - Genes Chromosomes Cancer. 2004 Aug;40(4):365-70 17589525 - Nat Struct Mol Biol. 2007 Jul;14(7):620-9 21753750 - Nature. 2011 Jul 21;475(7356):408-11 11473790 - Prog Neurobiol. 2001 Oct;65(3):289-308 16429136 - Nat Neurosci. 2006 Feb;9(2):180-7 18725517 - Development. 2008 Sep;135(18):3125-35 Martinez-Contreras ( key 20170512141925_gks504-B26) 2007; 623 Kim ( key 20170512141925_gks504-B51) 2007; 35 Kvissel ( key 20170512141925_gks504-B39) 2007; 313 Warf ( key 20170512141925_gks504-B23) 2009; 106 Qin ( key 20170512141925_gks504-B44) 2003; 100 Cryan ( key 20170512141925_gks504-B62) 2010; 58 Valcarcel ( key 20170512141925_gks504-B18) 1993; 362 Xie ( key 20170512141925_gks504-B34) 2003; 100 Mikhail ( key 20170512141925_gks504-B66) 2006; 207 Silva ( key 20170512141925_gks504-B63) 2010; 706 Graveley ( key 20170512141925_gks504-B1) 2001; 17 Bark ( key 20170512141925_gks504-B45) 2004; 24 Wang ( key 20170512141925_gks504-B4) 2008; 456 Theriault ( key 20170512141925_gks504-B54) 2005; 25 Stifani ( key 20170512141925_gks504-B57) 2008; 105 Sacchi ( key 20170512141925_gks504-B71) 1994; 11 Perkins ( key 20170512141925_gks504-B50) 1999; 20 Heyd ( key 20170512141925_gks504-B9) 2011; 36 Hai ( key 20170512141925_gks504-B35) 2008; 36 Shi ( key 20170512141925_gks504-B40) 2011; 286 Han ( key 20170512141925_gks504-B25) 2010; 430 Expert-Bezancon ( key 20170512141925_gks504-B28) 2002; 277 Ma ( key 20170512141925_gks504-B37) 2007; 1773 Lallena ( key 20170512141925_gks504-B21) 2002; 109 Black ( key 20170512141925_gks504-B3) 2003; 72 Wang ( key 20170512141925_gks504-B13) 2008; 14 Revil ( key 20170512141925_gks504-B27) 2009; 284 Venables ( key 20170512141925_gks504-B29) 2008; 28 Marmigere ( key 20170512141925_gks504-B53) 2007; 8 Smith ( key 20170512141925_gks504-B12) 2000; 25 Lindstrand ( key 20170512141925_gks504-B60) 2010; 77 Vilardell ( key 20170512141925_gks504-B58) 2011; 12 Corsini ( key 20170512141925_gks504-B20) 2007; 14 Johansson ( key 20170512141925_gks504-B46) 2008; 4 Nucifora ( key 20170512141925_gks504-B69) 1994; 91 Kramer ( key 20170512141925_gks504-B55) 2006; 49 Kobayashi ( key 20170512141925_gks504-B56) 2011; 49 Xie ( key 20170512141925_gks504-B33) 2008; 1779 Chijiwa ( key 20170512141925_gks504-B48) 1990; 265 Grabowski ( key 20170512141925_gks504-B7) 2001; 65 Mackereth ( key 20170512141925_gks504-B65) 2011; 475 Hall-Pogar ( key 20170512141925_gks504-B43) 2007; 13 Thisted ( key 20170512141925_gks504-B24) 2001; 276 Cooper ( key 20170512141925_gks504-B6) 2009; 136 Liu ( key 20170512141925_gks504-B72) 2008; 135 Xie ( key 20170512141925_gks504-B30) 2001; 410 Mikhail ( key 20170512141925_gks504-B68) 2004; 39 Maniatis ( key 20170512141925_gks504-B2) 2002; 418 Habelhah ( key 20170512141925_gks504-B42) 2001; 3 Shin ( key 20170512141925_gks504-B11) 2004; 5 Singh ( key 20170512141925_gks504-B16) 2000; 6 Tronchere ( key 20170512141925_gks504-B15) 1997; 388 Giguere ( key 20170512141925_gks504-B67); 202 Heiner ( key 20170512141925_gks504-B22) 2010; 7 Lutterbach ( key 20170512141925_gks504-B64) 2000; 275 Li ( key 20170512141925_gks504-B8) 2007; 8 Benderska ( key 20170512141925_gks504-B38) 2010; 1799 Zhang ( key 20170512141925_gks504-B70) 2004; 40 Marmigere ( key 20170512141925_gks504-B52) 2006; 9 Yu ( key 20170512141925_gks504-B31) 2009; 284 Jarnaess ( key 20170512141925_gks504-B41) 2009; 284 Tazi ( key 20170512141925_gks504-B5) 2009; 1792 Raj ( key 20170512141925_gks504-B75) 2011; 43 Hepp ( key 20170512141925_gks504-B47) 2001; 12 Singh ( key 20170512141925_gks504-B17) 1995; 268 Li ( key 20170512141925_gks504-B32) 2009; 284 Stamm ( key 20170512141925_gks504-B10) 2008; 283 Moore ( key 20170512141925_gks504-B14) 2000; 7 Gabut ( key 20170512141925_gks504-B74) 2011; 147 Cao ( key 20170512141925_gks504-B36) 2011; 86 Xie ( key 20170512141925_gks504-B49) 1998; 280 Katzaki ( key 20170512141925_gks504-B59) 2010; 152A Liu ( key 20170512141925_gks504-B73) 2011; 138 Shepard ( key 20170512141925_gks504-B19) 2002; 22 Beri-Dexheimer ( key 20170512141925_gks504-B61) 2008; 16 |
References_xml | – volume: 135 start-page: 3125 year: 2008 ident: key 20170512141925_gks504-B72 article-title: A crucial role for hnRNP K in axon development in Xenopus laevis publication-title: Development doi: 10.1242/dev.022236 contributor: fullname: Liu – volume: 8 start-page: 114 year: 2007 ident: key 20170512141925_gks504-B53 article-title: Specification and connectivity of neuronal subtypes in the sensory lineage publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2057 contributor: fullname: Marmigere – volume: 138 start-page: 3079 year: 2011 ident: key 20170512141925_gks504-B73 article-title: hnRNP K post-transcriptionally co-regulates multiple cytoskeletal genes needed for axonogenesis publication-title: Development doi: 10.1242/dev.066993 contributor: fullname: Liu – volume: 14 start-page: 620 year: 2007 ident: key 20170512141925_gks504-B20 article-title: U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 publication-title: Nat. Struct. Mol. Biol. doi: 10.1038/nsmb1260 contributor: fullname: Corsini – volume: 284 start-page: 16191 year: 2009 ident: key 20170512141925_gks504-B32 article-title: In vivo selection of kinase-responsive RNA elements controlling alternative splicing publication-title: J. Biol. Chem. doi: 10.1074/jbc.M900393200 contributor: fullname: Li – volume: 1799 start-page: 448 year: 2010 ident: key 20170512141925_gks504-B38 article-title: DARPP-32 binds to tra2-beta1 and influences alternative splicing publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2010.01.003 contributor: fullname: Benderska – volume: 152A start-page: 1711 year: 2010 ident: key 20170512141925_gks504-B59 article-title: Syndromic mental retardation with thrombocytopenia due to 21q22.11q22.12 deletion: report of three patients publication-title: Am. J. Med. Genet. A. doi: 10.1002/ajmg.a.33478 contributor: fullname: Katzaki – volume: 277 start-page: 16614 year: 2002 ident: key 20170512141925_gks504-B28 article-title: Heterogeneous nuclear ribonucleoprotein (hnRNP) K is a component of an intronic splicing enhancer complex that activates the splicing of the alternative exon 6A from chicken beta-tropomyosin pre-mRNA publication-title: J. Biol. Chem. doi: 10.1074/jbc.M201083200 contributor: fullname: Expert-Bezancon – volume: 36 start-page: 397 year: 2011 ident: key 20170512141925_gks504-B9 article-title: Degrade, move, regroup: signaling control of splicing proteins publication-title: Trends Biochem. Sci. doi: 10.1016/j.tibs.2011.04.003 contributor: fullname: Heyd – volume: 268 start-page: 1173 year: 1995 ident: key 20170512141925_gks504-B17 article-title: Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins publication-title: Science doi: 10.1126/science.7761834 contributor: fullname: Singh – volume: 25 start-page: 381 year: 2000 ident: key 20170512141925_gks504-B12 article-title: Alternative pre-mRNA splicing: the logic of combinatorial control publication-title: Trends Biochem. Sci. doi: 10.1016/S0968-0004(00)01604-2 contributor: fullname: Smith – volume: 4 start-page: e1000278 year: 2008 ident: key 20170512141925_gks504-B46 article-title: An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000278 contributor: fullname: Johansson – volume: 49 start-page: 379 year: 2006 ident: key 20170512141925_gks504-B55 article-title: A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification publication-title: Neuron doi: 10.1016/j.neuron.2006.01.008 contributor: fullname: Kramer – volume: 280 start-page: 443 year: 1998 ident: key 20170512141925_gks504-B49 article-title: Control of alternative splicing of potassium channels by stress hormones publication-title: Science (Washington, DC) doi: 10.1126/science.280.5362.443 contributor: fullname: Xie – volume: 418 start-page: 236 year: 2002 ident: key 20170512141925_gks504-B2 article-title: Alternative pre-mRNA splicing and proteome expansion in metazoans publication-title: Nature doi: 10.1038/418236a contributor: fullname: Maniatis – volume: 3 start-page: 325 year: 2001 ident: key 20170512141925_gks504-B42 article-title: ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation publication-title: Nat. Cell. Biol. doi: 10.1038/35060131 contributor: fullname: Habelhah – volume: 86 start-page: 1061 year: 2011 ident: key 20170512141925_gks504-B36 article-title: Differential effects of PKA-controlled CaMKK2 variants on neuronal differentiation publication-title: RNA Biol. doi: 10.4161/rna.8.6.16691 contributor: fullname: Cao – volume: 284 start-page: 21458 year: 2009 ident: key 20170512141925_gks504-B27 article-title: Heterogeneous nuclear ribonucleoprotein K represses the production of pro-apoptotic Bcl-xS splice isoform publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.019711 contributor: fullname: Revil – volume: 286 start-page: 14639 year: 2011 ident: key 20170512141925_gks504-B40 article-title: Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10: a mechanism involved in tau pathology of Alzheimer disease publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.204453 contributor: fullname: Shi – volume: 49 start-page: 23 year: 2011 ident: key 20170512141925_gks504-B56 article-title: Runx1 promotes neuronal differentiation in dorsal root ganglion publication-title: Mol. Cell. Neurosci. doi: 10.1016/j.mcn.2011.08.009 contributor: fullname: Kobayashi – volume: 7 start-page: 56 year: 2010 ident: key 20170512141925_gks504-B22 article-title: HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition publication-title: RNA Biol. doi: 10.4161/rna.7.1.10402 contributor: fullname: Heiner – volume: 16 start-page: 1014 year: 2008 ident: key 20170512141925_gks504-B61 article-title: Clinical phenotype of germline RUNX1 haploinsufficiency: from point mutations to large genomic deletions publication-title: Eur. J. Hum. Genet. doi: 10.1038/ejhg.2008.89 contributor: fullname: Beri-Dexheimer – volume: 265 start-page: 5267 year: 1990 ident: key 20170512141925_gks504-B48 article-title: Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)34116-X contributor: fullname: Chijiwa – volume: 91 start-page: 4004 year: 1994 ident: key 20170512141925_gks504-B69 article-title: Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.91.9.4004 contributor: fullname: Nucifora – volume: 40 start-page: 365 year: 2004 ident: key 20170512141925_gks504-B70 article-title: PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22) publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.20050 contributor: fullname: Zhang – volume: 24 start-page: 8796 year: 2004 ident: key 20170512141925_gks504-B45 article-title: Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1940-04.2004 contributor: fullname: Bark – volume: 430 start-page: 379 year: 2010 ident: key 20170512141925_gks504-B25 article-title: Functional diversity of the hnRNPs: past, present and perspectives publication-title: Biochem. J. doi: 10.1042/BJ20100396 contributor: fullname: Han – volume: 28 start-page: 6033 year: 2008 ident: key 20170512141925_gks504-B29 article-title: Multiple and specific mRNA processing targets for the major human hnRNP proteins publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00726-08 contributor: fullname: Venables – volume: 9 start-page: 180 year: 2006 ident: key 20170512141925_gks504-B52 article-title: The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons publication-title: Nat. Neurosci. doi: 10.1038/nn1631 contributor: fullname: Marmigere – volume: 17 start-page: 100 year: 2001 ident: key 20170512141925_gks504-B1 article-title: Alternative splicing: increasing diversity in the proteomic world publication-title: Trends Genet. doi: 10.1016/S0168-9525(00)02176-4 contributor: fullname: Graveley – volume: 20 start-page: 3551 year: 1999 ident: key 20170512141925_gks504-B50 article-title: Probability-based protein identification by searching sequence databases using mass spectrometry data publication-title: Electrophoresis doi: 10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2 contributor: fullname: Perkins – volume: 276 start-page: 17484 year: 2001 ident: key 20170512141925_gks504-B24 article-title: Optimized RNA targets of two closely related triple KH domain proteins, heterogeneous nuclear ribonucleoprotein K and alphaCP-2KL, suggest Distinct modes of RNA recognition publication-title: J. Biol. Chem. doi: 10.1074/jbc.M010594200 contributor: fullname: Thisted – volume: 12 start-page: 229 year: 2011 ident: key 20170512141925_gks504-B58 article-title: Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes publication-title: BMC Genomics doi: 10.1186/1471-2164-12-229 contributor: fullname: Vilardell – volume: 22 start-page: 221 year: 2002 ident: key 20170512141925_gks504-B19 article-title: Characterization of U2AF26, a splicing factor related to U2AF35 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.22.1.221-230.2002 contributor: fullname: Shepard – volume: 202 start-page: 94 ident: key 20170512141925_gks504-B67 article-title: CLCA2, a novel RUNX1 partner gene in a therapy-related leukemia with t(1;21)(p22;q22) publication-title: Cancer Genet. Cytogenet doi: 10.1016/j.cancergencyto.2010.07.116 contributor: fullname: Giguere – volume: 43 start-page: 843 year: 2011 ident: key 20170512141925_gks504-B75 article-title: Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis publication-title: Mol. Cell. doi: 10.1016/j.molcel.2011.08.014 contributor: fullname: Raj – volume: 706 start-page: 59 year: 2010 ident: key 20170512141925_gks504-B63 article-title: The latrophilins, “split-personality” receptors publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4419-7913-1_5 contributor: fullname: Silva – volume: 410 start-page: 936 year: 2001 ident: key 20170512141925_gks504-B30 article-title: A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels publication-title: Nature doi: 10.1038/35073593 contributor: fullname: Xie – volume: 58 start-page: 427 year: 2010 ident: key 20170512141925_gks504-B62 article-title: GABAB receptors and depression. Current status publication-title: Adv. Pharmacol. doi: 10.1016/S1054-3589(10)58016-5 contributor: fullname: Cryan – volume: 12 start-page: 673 year: 2001 ident: key 20170512141925_gks504-B47 article-title: NGF enhances depolarization effects on SNAP-25 expression: induction of SNAP-25b isoform publication-title: Neuroreport doi: 10.1097/00001756-200103260-00011 contributor: fullname: Hepp – volume: 275 start-page: 651 year: 2000 ident: key 20170512141925_gks504-B64 article-title: A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia publication-title: J. Biol. Chem. doi: 10.1074/jbc.275.1.651 contributor: fullname: Lutterbach – volume: 105 start-page: 6451 year: 2008 ident: key 20170512141925_gks504-B57 article-title: Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0711299105 contributor: fullname: Stifani – volume: 100 start-page: 183 year: 2003 ident: key 20170512141925_gks504-B44 article-title: Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.232688199 contributor: fullname: Qin – volume: 77 start-page: 145 year: 2010 ident: key 20170512141925_gks504-B60 article-title: Detailed molecular and clinical characterization of three patients with 21q deletions publication-title: Clin. Genet doi: 10.1111/j.1399-0004.2009.01289.x contributor: fullname: Lindstrand – volume: 388 start-page: 397 year: 1997 ident: key 20170512141925_gks504-B15 article-title: A protein related to splicing factor U2AF-35 that interacts with U2AF-65 and SR proteins in splicing of pre-mRNA publication-title: Nature (London) doi: 10.1038/41137 contributor: fullname: Tronchere – volume: 456 start-page: 470 year: 2008 ident: key 20170512141925_gks504-B4 article-title: Alternative isoform regulation in human tissue transcriptomes publication-title: Nature doi: 10.1038/nature07509 contributor: fullname: Wang – volume: 100 start-page: 8776 year: 2003 ident: key 20170512141925_gks504-B34 article-title: Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1432696100 contributor: fullname: Xie – volume: 362 start-page: 171 year: 1993 ident: key 20170512141925_gks504-B18 article-title: The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA publication-title: Nature doi: 10.1038/362171a0 contributor: fullname: Valcarcel – volume: 35 start-page: D93 year: 2007 ident: key 20170512141925_gks504-B51 article-title: The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species publication-title: Nucleic Acids Res doi: 10.1093/nar/gkl884 contributor: fullname: Kim – volume: 475 start-page: 408 year: 2011 ident: key 20170512141925_gks504-B65 article-title: Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF publication-title: Nature doi: 10.1038/nature10171 contributor: fullname: Mackereth – volume: 8 start-page: 819 year: 2007 ident: key 20170512141925_gks504-B8 article-title: Neuronal regulation of alternative pre-mRNA splicing publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn2237 contributor: fullname: Li – volume: 5 start-page: 727 year: 2004 ident: key 20170512141925_gks504-B11 article-title: Cell signalling and the control of pre-mRNA splicing publication-title: Nat. Rev. Mol. Cell. Biol. doi: 10.1038/nrm1467 contributor: fullname: Shin – volume: 1779 start-page: 438 year: 2008 ident: key 20170512141925_gks504-B33 article-title: Control of alternative pre-mRNA splicing by Ca(++) signals publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbagrm.2008.01.003 contributor: fullname: Xie – volume: 6 start-page: 901 year: 2000 ident: key 20170512141925_gks504-B16 article-title: Differential recognition of the polypyrimidine-tract by the general splicing factor U2AF65 and the splicing repressor sex-lethal publication-title: RNA doi: 10.1017/S1355838200000376 contributor: fullname: Singh – volume: 72 start-page: 291 year: 2003 ident: key 20170512141925_gks504-B3 article-title: Mechanisms of alternative pre-messenger rna splicing publication-title: Annu. Rev. Biochem. doi: 10.1146/annurev.biochem.72.121801.161720 contributor: fullname: Black – volume: 39 start-page: 110 year: 2004 ident: key 20170512141925_gks504-B68 article-title: A novel gene, FGA7, is fused to RUNX1/AML1 in a t(4;21)(q28;q22) in a patient with T-cell acute lymphoblastic leukemia publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.10302 contributor: fullname: Mikhail – volume: 136 start-page: 777 year: 2009 ident: key 20170512141925_gks504-B6 article-title: RNA and disease publication-title: Cell doi: 10.1016/j.cell.2009.02.011 contributor: fullname: Cooper – volume: 283 start-page: 1223 year: 2008 ident: key 20170512141925_gks504-B10 article-title: Regulation of alternative splicing by reversible protein phosphorylation publication-title: J. Biol. Chem. doi: 10.1074/jbc.R700034200 contributor: fullname: Stamm – volume: 207 start-page: 582 year: 2006 ident: key 20170512141925_gks504-B66 article-title: Normal and transforming functions of RUNX1: a perspective publication-title: J. Cell. Physiol. doi: 10.1002/jcp.20538 contributor: fullname: Mikhail – volume: 7 start-page: 14 year: 2000 ident: key 20170512141925_gks504-B14 article-title: Intron recognition comes of AGe publication-title: Nat. Struct. Biol. doi: 10.1038/71207 contributor: fullname: Moore – volume: 1773 start-page: 912 year: 2007 ident: key 20170512141925_gks504-B37 article-title: Relocalization of the polypyrimidine tract-binding protein during PKA-induced neurite growth publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2007.02.006 contributor: fullname: Ma – volume: 106 start-page: 9203 year: 2009 ident: key 20170512141925_gks504-B23 article-title: The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0900342106 contributor: fullname: Warf – volume: 14 start-page: 802 year: 2008 ident: key 20170512141925_gks504-B13 article-title: Splicing regulation: from a parts list of regulatory elements to an integrated splicing code publication-title: RNA doi: 10.1261/rna.876308 contributor: fullname: Wang – volume: 313 start-page: 2795 year: 2007 ident: key 20170512141925_gks504-B39 article-title: Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing publication-title: Exp. Cell. Res. doi: 10.1016/j.yexcr.2007.05.014 contributor: fullname: Kvissel – volume: 284 start-page: 35154 year: 2009 ident: key 20170512141925_gks504-B41 article-title: Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.056465 contributor: fullname: Jarnaess – volume: 147 start-page: 132 year: 2011 ident: key 20170512141925_gks504-B74 article-title: An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming publication-title: Cell doi: 10.1016/j.cell.2011.08.023 contributor: fullname: Gabut – volume: 13 start-page: 1103 year: 2007 ident: key 20170512141925_gks504-B43 article-title: Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR publication-title: RNA doi: 10.1261/rna.577707 contributor: fullname: Hall-Pogar – volume: 36 start-page: 3320 year: 2008 ident: key 20170512141925_gks504-B35 article-title: A G-tract element in apoptotic agents-induced alternative splicing publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn207 contributor: fullname: Hai – volume: 109 start-page: 285 year: 2002 ident: key 20170512141925_gks504-B21 article-title: Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45 publication-title: Cell doi: 10.1016/S0092-8674(02)00730-4 contributor: fullname: Lallena – volume: 25 start-page: 2050 year: 2005 ident: key 20170512141925_gks504-B54 article-title: Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5108-04.2005 contributor: fullname: Theriault – volume: 1792 start-page: 14 year: 2009 ident: key 20170512141925_gks504-B5 article-title: Alternative splicing and disease publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2008.09.017 contributor: fullname: Tazi – volume: 623 start-page: 123 year: 2007 ident: key 20170512141925_gks504-B26 article-title: hnRNP proteins and splicing control publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-0-387-77374-2_8 contributor: fullname: Martinez-Contreras – volume: 284 start-page: 1505 year: 2009 ident: key 20170512141925_gks504-B31 article-title: The heterogeneous nuclear ribonucleoprotein L is an essential component in the Ca++/calmodulin-dependent protein kinase IV-regulated alternative splicing through cytidine-adenosine repeats publication-title: J. Biol. Chem. doi: 10.1074/jbc.M805113200 contributor: fullname: Yu – volume: 11 start-page: 226 year: 1994 ident: key 20170512141925_gks504-B71 article-title: AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts publication-title: Genes Chromosomes Cancer doi: 10.1002/gcc.2870110405 contributor: fullname: Sacchi – volume: 65 start-page: 289 year: 2001 ident: key 20170512141925_gks504-B7 article-title: Alternative RNA splicing in the nervous system publication-title: Prog. Neurobiol. doi: 10.1016/S0301-0082(01)00007-7 contributor: fullname: Grabowski |
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Snippet | The molecular basis of cell signal-regulated alternative splicing at the 3' splice site remains largely unknown. We isolated a protein kinase A-responsive... The molecular basis of cell signal-regulated alternative splicing at the 3′ splice site remains largely unknown. We isolated a protein kinase A-responsive... |
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SubjectTerms | Alternative Splicing - drug effects Amino Acid Sequence Animals Base Sequence Colforsin - pharmacology Core Binding Factor Alpha 2 Subunit - genetics Core Binding Factor Alpha 2 Subunit - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Exons HEK293 Cells Heterogeneous-Nuclear Ribonucleoprotein K - chemistry Heterogeneous-Nuclear Ribonucleoprotein K - metabolism Humans Molecular Sequence Data Nervous System Diseases - genetics Neurites - drug effects Neurites - ultrastructure Neurogenesis - genetics Neurons - cytology Neurons - metabolism Nuclear Proteins - metabolism Nucleotide Motifs PC12 Cells Rats Regulatory Sequences, Ribonucleic Acid Ribonucleoproteins - metabolism RNA RNA Splice Sites Sequence Alignment Splicing Factor U2AF Synaptosomal-Associated Protein 25 - genetics Synaptosomal-Associated Protein 25 - metabolism |
Title | Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation |
URI | https://www.ncbi.nlm.nih.gov/pubmed/22684629 https://search.proquest.com/docview/1093454417 https://pubmed.ncbi.nlm.nih.gov/PMC3439897 |
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