Oxycodone accumulation in a hemodialysis patient

• Published in: Southern medical journal (Birmingham, Ala.) Vol. 100; no. 2; pp. 212 - 214
• Main Authors: FORAL, Pamela A, INECK, Joseph R, NYSTROM, Kelly K
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.02.2007; Southern Medical Association
• Subjects: Adult; Analgesics; Analgesics, Opioid - adverse effects; Analgesics, Opioid - pharmacokinetics; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Complications and side effects; Dosage and administration; Drug therapy; Emergency and intensive care: renal failure. Dialysis management; Follow-Up Studies; General aspects; Hemodialysis; Humans; Hypotension - blood; Hypotension - chemically induced; Intensive care medicine; Kidney failure; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Lethargy - blood; Lethargy - chemically induced; Male; Medical sciences; Oxycodone; Oxycodone - adverse effects; Oxycodone - pharmacokinetics; Renal Dialysis; Respiratory Insufficiency - blood; Respiratory Insufficiency - chemically induced; United States; Human; Medicine; Extrarenal dialysis; Hemodialysis; Oxycodone; Opiates; Patient; Narcotic analgesic; Accumulation

Oxycodone and oxycodone-containing analgesics are often used for the relief of pain. In the presence of renal dysfunction, the half-life of oxycodone and metabolites can be prolonged. We describe the case of a 41-year-old chronic hemodialysis patient who received multiple doses of oxycodone/acetamin...