Effect of L-Carnitine Supplementation on Apelin and Apelin Receptor (Apj) Expression in Cardiac Muscle of Obese Diabetic Rats

• Published in: Cell journal (Yakhteh) Vol. 20; no. 3; pp. 427 - 434
• Main Authors: Ranjbar Kohan, Neda, Nazifi, Saeed, Tabandeh, Mohammad Reza, Ansari Lari, Maryam
• Format: Journal Article
• Language: English
• Published: Iran Royan Institute of Iran 01.10.2018; Royan Institute; Royan Institute (ACECR), Tehran
• Subjects: Apelin; Apelin Receptor; Carbohydrates; Cardiac Muscle; Cardiovascular disease; Cardiovascular diseases; Carnitine; Complications; Diabetes; Diabetes mellitus; Diet; Dietary supplements; Drinking water; Gene expression; Glucose; Heart diseases; High carbohydrate diet; High fat diet; Homeostasis; IL-1β; Inflammation; Insulin; Insulin resistance; Interleukins; L-Carnitine; Lipids; Metabolism; Muscles; Obesity; Original; Overexpression; Patients; Polymerase chain reaction; Rats; Receptors; Rodents; Serum levels; Streptozocin; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Iran; L-Carnitine; Cardiac Muscle; Diabetes; Apelin Receptor; Apelin

L-carnitine (LC) has been shown to protect cardiac metabolism in diabetes patients with cardiovascular diseases (CVDs). Apelin, a newly discovered adipocytokines, is an important regulator of cardiac muscle function; however, the role of the level of expression of Apelin axis in improvement of cardi...