Identification of two paralogous caprine CD36 genes that display highly divergent mRNA expression profiles

• Published in: Comparative immunology, microbiology and infectious diseases Vol. 36; no. 1; pp. 1 - 7
• Main Authors: Zidi, A, Castelló, A, Jordana, J, Carrizosa, J, Urrutia, B, Serradilla, J.M, Amills, M
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.01.2013; Elsevier
• Subjects: Adipose tissue; Alleles; Allergy and Immunology; Amino Acid Sequence; Animals; Biological and medical sciences; CD36 Antigens - chemistry; CD36 Antigens - genetics; CD36 Antigens - metabolism; CD36 gene; Female; Fundamental and applied biological sciences. Psychology; Gene duplication; Gene Expression Profiling; Gene Frequency; Genetic Loci; Genome; Genotype; Goat; Goats - genetics; Goats - metabolism; Infectious Disease; Microbiology; Milk - cytology; Phylogeny; Polymorphism, Genetic; RNA, Messenger - metabolism; Ruminantia; Goat; Gene duplication; CD36 gene; Farming animal; Caprine; Identification; Infection; Vertebrata; Mammalia; Immunology; Messenger RNA; Gene; Artiodactyla; Ungulata

Abstract The CD36 molecule plays a pivotal role in a variety of immunological and cellular processes, including pathogen recognition, inflammation and apoptosis. Herein, we demonstrate that this gene is duplicated in goats, with two copies ( CD36 and CD36-like ) that display highly divergent mRNA ex...