In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma

• Published in: Cancer research (Chicago, Ill.) Vol. 82; no. 8; pp. 1548 - 1559
• Main Authors: Younger, Nicholas T, Wilson, Mollie L, Martinez Lyons, Anabel, Jarman, Edward J, Meynert, Alison M, Grimes, Graeme R, Gournopanos, Konstantinos, Waddell, Scott H, Tennant, Peter A, Wilson, David H, Guest, Rachel V, Wigmore, Stephen J, Acosta, Juan Carlos, Kendall, Timothy J, Taylor, Martin S, Sproul, Duncan, Mill, Pleasantine, Boulter, Luke
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 15.04.2022
• Subjects: Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - pathology; Bile Ducts, Intrahepatic - pathology; Cholangiocarcinoma - genetics; Cholangiocarcinoma - pathology; Genetic Heterogeneity; Humans; Molecular Cell Biology; Phosphatidylinositol 3-Kinases - genetics

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy of the bile ducts within the liver characterized by high levels of genetic heterogeneity. In the context of such genetic variability, determining which oncogenic mutations drive ICC growth has been difficult, and developing modes of p...