A single nucleotide polymorphism in the human bone morphogenetic protein-2 gene (109T>G) affects the Smad signaling pathway and the predisposition to ossification of the posterior longitudinal ligament of the spine

• Published in: Chinese medical journal Vol. 126; no. 6; pp. 1112 - 1118
• Main Authors: Yan, Liang, Chang, Zhen, Liu, Yang, Li, Yi-bing, He, Bao-rong, Hao, Ding-jun
• Format: Journal Article
• Language: English
• Published: China Department of Spine Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an,Shaanxi 710054, China%Department of Orthopaedics, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an,Shaanxi 710054, China 20.03.2013
• Subjects: Adult; Aged; Bone Morphogenetic Protein 2 - genetics; Cells, Cultured; Female; Humans; In Situ Hybridization; Longitudinal Ligaments - metabolism; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Signal Transduction - genetics; Signal Transduction - physiology; Smad Proteins - metabolism; Spine - metabolism; single nucleotide polymorphisms; signal transduction; ossification of the posterior longitudinal ligament; bone morphogenetic protein-2

Although various systemic and local factors such as abnormal carbohydrate or calcium metabolism, aging, and hormonal disturbances have been suggested as causes of ossification of the posterior longitudinal ligament (OPLL), the etiology of OPLL is not fully understood. The purpose of this study was t...