Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation

• Published in: Human molecular genetics Vol. 24; no. 6; pp. 1528 - 1539
• Main Authors: Cotton, Allison M., Price, E. Magda, Jones, Meaghan J., Balaton, Bradley P., Kobor, Michael S., Brown, Carolyn J.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.03.2015
• Subjects: Chromatin - metabolism; Chromosomes, Human, X; CpG Islands; DNA Methylation; DNA, Intergenic; Female; Gene Expression Regulation; Humans; Oligonucleotide Array Sequence Analysis; Organ Specificity; Promoter Regions, Genetic; Transcription, Genetic; X Chromosome Inactivation

X-chromosome inactivation (XCI) achieves dosage compensation between males and females through the silencing of the majority of genes on one of the female X chromosomes. Thus, the female X chromosomes provide a unique opportunity to study euchromatin and heterochromatin of allelic regions within the...