Activation of a non-neuronal cholinergic system in visceral white adipose tissue of obese mice and humans

• Published in: Molecular metabolism (Germany) Vol. 79; p. 101862
• Main Authors: Severi, Ilenia, Perugini, Jessica, Ruocco, Chiara, Coppi, Lara, Pedretti, Silvia, Di Mercurio, Eleonora, Senzacqua, Martina, Ragni, Maurizio, Imperato, Gabriele, Valerio, Alessandra, Mitro, Nico, Crestani, Maurizio, Nisoli, Enzo, Giordano, Antonio
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.01.2024; Elsevier
• Subjects: Acetylcholine; Choline; Inflammation; Insulin resistance; Macrophages; Obesity; Original; Obesity; Insulin resistance; Acetylcholine; Inflammation; Macrophages; Choline
• ISSN: 2212-8778; 2212-8778
• DOI: 10.1016/j.molmet.2023.101862

Since white adipose tissue (WAT) lacks parasympathetic cholinergic innervation, the source of the acetylcholine (ACh) acting on white adipocyte cholinergic receptors is unknown. This study was designed to identify ACh-producing cells in mouse and human visceral WAT and to determine whether a non-neu...